Optimizing Small Water Bodies as a Nature-Based Solution for Mitigating Nitrogen Pollution.

Despite the widely acknowledged importance of small water bodies (SWBs), their large-scale capacity for nitrogen (N) removal in agricultural landscapes remains poorly understood. This study assessed the N removal efficiency and potential of 1.75 million SWBs (<0.

Machine learning-driven method for in-situ high-frequency CH measurement in paddy fields based on water-soil-air factors: A case study of the Yangtze River Basin.

Accurate and high-frequency monitoring of methane (CH) from rice paddies is crucial for effective carbon emission control but remains challenging due to fluctuant emissions and complex field environments. This study proposed a new in-situ high-frequency CH4 measurement method based on machine learning and sensor-measurable water-soil-air environment factors. The results show that: (1) soil and paddy water serve as critical media influencing CH production and transportation, with paddy water depth (H), soil electrical conductivity (EC), and soil temperature (T) being significantly positively correlated with CH emission flux, while soil redox potential (Eh) had a negative effect (p < 0.

Therapeutic potential of the novel anthraquinone compound ESE in T2DM mice by inhibiting of TLR4/MyD88/NF-κB pathway.

Background And Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and pancreatic β-cell dysfunction. Although current medications such as metformin can effectively control blood glucose levels, their ability to improve β-cell function and suppress chronic inflammation remains limited. Emodin, a natural compound with anti-inflammatory, antioxidant, and insulin-sensitizing properties, has shown therapeutic promise; however, its clinical application is constrained by poor water solubility and low bioavailability.

Coexistence of hepatitis B e antigen and antibody during antiviral treatment predicts better clinical outcomes in children.

Objectives: The coexistence of hepatitis B e antigen (HBeAg) and hepatitis B e antibody (HBeAb) during antiviral therapy is considered atypical in patients with chronic hepatitis B (CHB), and its clinical implications remain inadequately understood, particularly in pediatric patients. This study aimed to investigate the clinical characteristics of this coexistence pattern and its impact on the outcomes of combined antiviral therapy in children with CHB.

Methods: A total of 254 treatment-naïve children diagnosed with HBeAg-positive CHB were retrospectively enrolled.

Deep Neural-Assisted Flexible MXene-Ag Composite Strain Sensor with Crack Dual Conductive Network for Human Motion Sensing.

Developing stretchable strain sensors that combine both high sensitivity and a wide linear range is a critical requirement for health electronics, yet it remains challenging to meet the practical demands of daily health monitoring. This study proposes a novel heterogeneous surface strategy by in situ silver deposition on modified PDMS followed by MXene spray coating, constructing a multilevel microcrack strain sensor (MAP) using silver nanoparticles and MXene. This innovative multilevel heterogeneous microcrack structure forms a dual conductive network, which demonstrates excellent detection performance within GF = 487.

Assessing Factors Affecting Postpartum Post-Traumatic Stress Disorder and Development of Risk Prediction Nomogram Model.

Background: Currently, the factors impacting postpartum post-traumatic stress disorder (PP-PTSD) remain unclear. Therefore, this study aimed to screen the PP-PTSD risk factors and to develop an effective and user-friendly column chart prediction model (nomogram), thereby providing a basis for early clinical diagnosis and prompt intervention.

Methods: This retrospective study collected 180 postpartum women between January 2023 and December 2023.

Comparison of MR cytometry methods in predicting immunohistochemical factor status and molecular subtypes of breast cancer.

Background: First evaluation of the performance of MR cytometry incorporating transcytolemmal water exchange in predicting immunohistochemical factor status and molecular subtypes of breast cancer.

Patients And Methods: We prospectively enrolled 90 breast cancer patients in the study. For each participant, pulsed gradient spin-echo (PGSE) with diffusion time of 70 ms and oscillating gradient spin-echo (OGSE) diffusion-weighted imaging of 25 Hz and 50 Hz were performed on a 3T MRI scanner.

Humic acid-based Fe/Ag bimetallic Fenton-like catalysts for efficient degradation of sulfadiazine in water.

Humic acid (HA) was a natural organic macromolecule, which was considered as an ideal carrier for Fenton-like catalysts due to the large number of active functional groups on its surface. For this reason, humic acid-based Fe/Ag bimetallic catalysts (FeO/HA/Ag) were synthesized by introducing Fe and Ag to the humic acid carrier. The morphology and physicochemical properties of FeO/HA/Ag was revealed by different characterization methods.

Therapeutic Repair of Sperm Quality Decline Caused by Polytetrafluoroethylene.

The alarming prevalence of environmental microplastics has raised global concerns about fertility. However, the detriment of polytetrafluoroethylene (PTFE, Teflon), a widely used microplastic in non-stick cookware, to sperm quality remains unclear. Here, a high detection rate (46.

Precision sniper for solid tumors: CAR-NK cell therapy.

Chimeric antigen receptor (CAR) represents a novel targeted therapy that uses genetic engineering to modify effector cells for precise tumor cell targeting. Chimeric antigen receptor-T (CAR-T) cell immunotherapy, which employs T cells as effectors, has demonstrated significant efficacy in treating hematologic malignancies. However, its efficacy against solid tumors remains inadequate and is accompanied by toxic side effects, including cytokine release syndrome, neurotoxicity and on-target/off-tumor effects.

Integrative causal inference illuminates gene-environment interactions linking endocrine disruptors to female infertility.

Female infertility, a global health concern affecting up to 12 % of women, is influenced by genetic, hormonal, and environmental factors. Among environmental contributors, endocrine-disrupting chemicals (EDCs), which interfere with hormonal systems, have gained attention for their potential impact on reproductive health. This study used Mendelian randomization (MR) and colocalization analyses to explore the causal relationships between gene expression influenced by EDCs and female infertility.

Single-nucleotide polymorphisms in genes involved in folate metabolism or selected other metabolites and risk for gestational diabetes mellitus.

Background: There are conflicting results on the potential correlation between folic acid and gestational diabetes mellitus (GDM), and the correlation between genetic factors related to folic acid metabolism pathways and GDM remains to be revealed.

Aim: To examine the association between single-nucleotide polymorphisms (SNPs) of enzyme genes in the folate metabolite pathway as well as that between GDM-related genes and risk for GDM.

Methods: A nested case-control study was conducted with GDM cases ( = 412) and healthy controls ( = 412).

Adverse childhood experiences and fertility intention among college students in China: moderated mediation effects of resilience and attachment.

Background: The declining fertility rates and aging are becoming major demographic and public health challenges. According to the life course theory, an individual’s current fertility intention is shaped by past experiences, with adverse childhood experiences (ACEs) known to have long-term effects on adult physiology, psychology, and society. Existing literature indicates that attachment styles and resilience are important factors in shaping psychological responses to ACEs and may play a role in influencing fertility intentions over time.

Comprehensive characterization of tumor therapeutic response via simultaneous mapping of cell size, density, and transcytolemmal water exchange.

The evaluation of tumor response to neoadjuvant chemotherapy is critical for the personalized management of cancer patients, aiming to minimize unnecessary toxicity, costs, and treatment delays. Current imaging techniques primarily depend on detecting tumor volume changes, which reflect downstream effects. In contrast, advanced microstructural diffusion MRI (dMRI) methods offer cellular-level insights but are limited by biased estimates of cell density due to oversimplified biophysical models.

Modifying MnO by CeO for enhanced electrocatalytic water oxidation.

A simple anion-assisted cathodic co-electrodeposition method is used to prepare CeO-modified MnO nanoflakes on carbon cloth. The CeO modifies the redox properties of MnO and enhances its intrinsic OER performance. It requires a low overpotential of 266 mV to reach 10 mA cm in 1.

Exploring how economic level drives urban flood risk.

In recent years, measures proposed to address urban flooding caused by extreme rainfall often demand substantial investment, restricting their broad implementation. This study quantitatively assessed the inundation situations of 138 capital cities under both normal and extreme rainfall conditions. Using machine learning techniques, we found that grey infrastructure-closely commensurate with a city's economic development-dominates flood reduction during normal rainfall events.

Decoding the Impact of Theabrownin on Skeletal Muscle Function in Gestational Diabetic Offspring: Insights from Integrated Metabolome and Transcriptome Analysis.

Gestational diabetes mellitus (GDM) often leads to long-term metabolic issues, including skeletal muscle dysfunction in the offspring, with traditional managements focusing solely on blood glucose regulation and not addressing muscle metabolic and structural changes. Theabrownin (TB), a polyphenol derived from Pu-erh tea, has known antioxidant and metabolic benefits, but its effects on skeletal muscle function in GDM offspring remain unclear. In this study, GDM model was induced in mice, and their offspring were treated by TB.

Omnidirectionally Stretchable High-Performance Microbatteries Based on Nanocomposite Current Collectors.

Stretchable electronics are transforming next-generation wearables and robotics, creating a significant demand for compatible energy storage devices. Microbatteries, known for their compact and flat design, hold great promise but often face limitations of low strain tolerance and unidirectional stretchability. Here, we introduce omnidirectionally stretchable Zn-MnO microbatteries featuring innovative nanocomposite current collectors.

Efficacy of probiotics in patients with cognitive impairment: A systematic review and meta-analysis.

Objective: To conduct an in-depth exploration of the specific impacts of probiotics and prebiotic supplements on cognitive impairment, it is imperative to also investigate pertinent factors, including the optimal dosage of probiotics for enhancing cognitive function. This investigation is essential for optimizing probiotic interventions to prevent and treat cognitive decline, aimed at preventing and aiding in the treatment of cognitive decline among patients with cognitive impairment.

Methods: A comprehensive computerized search was conducted across the Embase, PubMed, Web of Science, Cochrane Library, SinoMed, CNKI, Wanfang and WeiPu Data.

Knowledge mapping of tumor microenvironment for breast cancer: a bibliometric analysis from 2014 to 2023.

Introduction: Breast cancer is the most common malignant tumor among women worldwide, and the tumor microenvironment (TME) has become a hot research field in contemporary oncology. Understanding the TME is essential for elucidating the mechanisms of breast cancer progression and identifying novel therapeutic targets for metastasis and recurrence. This study performed a bibliometric analysis of TME research for breast cancer, providing a comprehensive overview of current research hotspots, development trends, and directions.

HBcrAg Dynamic Change During Treatment Predicts HBsAg Loss in Pediatric Patients With Chronic Hepatitis B.

In children with chronic hepatitis B(CHB), HBsAg loss is a critical indicator of functional cure. However, little is known about the correlation between the kinetics of HBcrAg and HBsAg loss in the pediatric population. The aim of this study was to investigate whether the HBcrAg change in children CHB patients receiving antiviral therapy is associated with the occurrence of HBsAg loss.

Interpretable machine learning reveals the importance of geography and landscape arrangement for surface water quality across China.

Elucidating the influence of land use patterns on surface water quality is crucial for effective watershed management. Despite numerous studies in individual watersheds, factors influencing water quality in diverse geographical environments are less understood due to data and methodological constraints in large-scale studies. This study employs Interpretable Machine Learning (IML) to explore the drivers of water quality variations across 234 watersheds in China.

Microalgae for phosphorus chemical wastewater treatment and recovery of phosphorus.

In this study, we have found a new method to recovery phosphorus selectively from high-fluoride-phosphoric wastewater. This new method was a microalgae-based phosphorus recovery technology.The results showed that Chlorella sp.