Publications by authors named "Sinan Hu"

Liver diseases have become a major challenge threating the global health, posing a heavy burden on both social and personal well-being. In recent years, the development of the gut-liver axis theory has provided new research perspectives and intervention strategies for the prevention and treatment of liver diseases. Natural products, recognized as biological molecules with diverse sources, rich activities, and minimal side effects, demonstrate great potential in regulating intestinal flora and improving liver health.

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Aging is known to cause significant changes in cognition, motor functions, emotional stability, and social behaviors. While research has documented age-related declines in these domains, there is a gap in understanding how aging affects middle-aged individuals, particularly in terms of sex differences. This study aims to fill this gap by examining behavioral changes in middle-aged mice compared to young adult mice, focusing on motor functions, anxiety-like behavior, recognition memory, and social behavior, and exploring sex differences in these domains.

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  • The buildup of senescent cells plays a significant role in aging and disease progression, highlighting the need to understand the mechanisms behind cellular senescence for better prevention and treatment strategies.
  • Traditional detection methods for senescent cells have limitations, including reliance on molecular protein levels and staining techniques, which do not capture changes in real time.
  • New technologies, like gene-edited mouse models and advanced probes, offer improved methods for detecting and studying senescent cells, paving the way for deeper insights into aging and related diseases.
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  • Osteoclast differentiation is crucial for bone resorption and involves the fusion of osteoclasts and their precursors.
  • Osteoprotegerin (OPG) inhibits this differentiation and fusion by affecting specific molecular markers and subcellular localization in osteoclasts and precursors.
  • ATP can counteract OPG's inhibitory effects, indicating a potential regulatory pathway that could be targeted for therapies related to bone metabolism.
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Human beings have always pursued a prolonged lifespan, while the aging of the nervous system is associated with a large variety of diseases. Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging.

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