Publications by authors named "Ruopeng Xiao"

Aging is known to cause significant changes in cognition, motor functions, emotional stability, and social behaviors. While research has documented age-related declines in these domains, there is a gap in understanding how aging affects middle-aged individuals, particularly in terms of sex differences. This study aims to fill this gap by examining behavioral changes in middle-aged mice compared to young adult mice, focusing on motor functions, anxiety-like behavior, recognition memory, and social behavior, and exploring sex differences in these domains.

View Article and Find Full Text PDF
Article Synopsis
  • The buildup of senescent cells plays a significant role in aging and disease progression, highlighting the need to understand the mechanisms behind cellular senescence for better prevention and treatment strategies.
  • Traditional detection methods for senescent cells have limitations, including reliance on molecular protein levels and staining techniques, which do not capture changes in real time.
  • New technologies, like gene-edited mouse models and advanced probes, offer improved methods for detecting and studying senescent cells, paving the way for deeper insights into aging and related diseases.
View Article and Find Full Text PDF

Human beings have always pursued a prolonged lifespan, while the aging of the nervous system is associated with a large variety of diseases. Pathological aging of the nervous system results in a series of neurodegenerative diseases and can cause disability and death in the elderly. Therefore, there is an urgent need for the prevention and treatment of nervous system aging.

View Article and Find Full Text PDF