Functional study on the regulation of lignin formation and disease resistance by the CpARF22 gene in Cucurbita pepo L.

The hull-less Cucurbita pepo L., also known as the naked-seeded pumpkin, is a relatively rare natural variant whose seeds closely resemble shelled pumpkin kernels, hence its name. The Fusarium wilt, caused by Fusarium oxysporum f.

Temporal trends in cross-country inequalities of permanent caries burden from 1990 to 2021: a secondary analysis of the global burden of disease study 2021.

Objective: To evaluate the changes in cross-national disparities in the burden of Permanent caries (PC) from 1990 to 2021.

Methods: We extracted the annual incidence and years lived with disability (YLDs), including their estimated annual percentage changes (EAPCs), categorized by year, age, geographical region, and socio-demographic index (SDI) from the Global Burden of Disease 2021. Correlation analysis was performed to evaluate the relationships among age-standardized rates (ASRs) of incidence, YLDs, and SDI.

Development and validation of an interpretable machine learning model for predicting Gleason score upgrade in prostate cancer.

Background: The high incidence of Gleason score upgrade (GSU) can lead urologists to underestimate tumor aggressiveness, resulting in suboptimal treatment decisions. This study aimed to develop an interpretable machine learning model to predict the risk of GSU in individuals with prostate cancer (PCa) based on readily available clinical parameters.

Methods: A retrospective analysis was conducted on patients who underwent radical prostatectomy (RP) at Shanghai General Hospital and West China Hospital.

Sex disparity in hepatocellular carcinoma recurrence after curative liver resection: a multicenter comprehensive analysis.

Background And Aims: The impact of sex disparity on the patterns of recurrence after curative resection of hepatocellular carcinoma (HCC) remains controversial. The aim of this study was to comprehensively investigate the influence of sex differences in HCC recurrence following curative hepatectomy.

Methods: Patients who underwent curative-intent resection for HCC between July 2015 and June 2020 were identified from a multicenter database and analyzed retrospectively.

Prognostic Value of Des-Gamma-Carboxy Prothrombin in AFP-Negative Hepatocellular Carcinoma Patients Following Liver Resection: .

Hepatocellular carcinoma (HCC) is a major global health concern with high postoperative recurrence rates. Des-gamma-carboxy prothrombin (DCP) is a promising biomarker for HCC prognosis, but its optimal cutoff value remains unclear, especially in AFP-negative patients. This study aimed to determine the ideal cutoff value of DCP in AFP-negative HCC patients following liver resection and to investigate its impact on long-term outcomes.

Chiral Aromatic Micelles as Chiroptical Host Tools for Large Metallodyes in Water.

In contrast to abundant aliphatic chiral cavities in nature, synthetic chiral cavities formed by self-assembly of aromatic subunits are quite rare, particularly providing an ability in induced chirality. Here, we report new chiral aromatic micelles capable of inducing the optical chirality of large metallodyes upon encapsulation. The aromatic micelle, with a core diameter of ∼3 nm, forms from axially chiral amphiphiles featuring a bent mesityl-substituted BINOL framework.

Self-management dilemmas and influencing factors of patients during the waiting period for heart transplantation in China based on the social ecosystem: a qualitative study.

Objectives: To investigate the self-management challenges and influencing factors faced by patients during the waiting period for heart transplantation through the lens of social ecology as well as to explore the family management needs of Chinese patients with end-stage heart disease during this critical waiting period.

Design: During March 2023 to March 2024, purposive sampling was adopted to conduct in-depth interviews with 11 patients awaiting heart transplantation and their primary caregivers at a Class III Grade A hospital in Nanjing, China. A phenomenological research approach was adopted, and Colaizzi's method was applied to analyse the data and extract the key themes.

Low-intensity pulsed ultrasound treatment in erectile dysfunction.

Low-intensity pulsed ultrasound (LIPUS) is a non-invasive sonodynamic therapy that has been approved by the U.S. Food and Drug Administration for clinical use.

Discovering the active components of Rosa davurica Pall on ameliorating acute myocardial ischemia based on spectral relationships, network pharmacology, molecular docking and molecular dynamic.

The Rosa davurica Pall (RDP) is a Chinese traditional medicine known for its potential in treating cardiovascular disorders. However, the specific compounds within RDP for its anti-myocardial ischemic activity have not been fully elucidated. The present study was intended to reveal the ameliorate myocardial ischemic component of RDP and to reveal its potential mechanism of action against myocardial ischemia.

Development and Initial Validation of the Multi-dimensional Attention Rating Scale in Highly Educated Adults.

Objectives: To report the development, validation, and findings of the Multi-dimensional Attention Rating Scale (MARS), a self-report tool crafted to evaluate six-dimension attention levels.

Methods: The MARS was developed based on Classical Test Theory (CTT) , with initial item selection and content validation conducted by six experts in psychiatry and psychology using the Delphi method. Healthy adult participants were recruited to complete the MARS and related scales, along with on-site measures.

Immunological profile of lactate metabolism-related genes in Psoriasis a comprehensive analysis based on bulk and single-cell RNA sequencing data.

Psoriasis (Pso) is a chronic erythema squamous disease often accompanied by metabolic abnormalities. Disturbances in lactate metabolism have been observed in the skin of patients with Pso, but the role of lactate metabolism in the pathogenesis of Pso remains unclear. To identify core genes associated with lactate metabolism in Pso, we downloaded and merged two Pso-related datasets (GSE13355, GSE109248) from the GEO database.

Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein.

Current anti-epileptic drugs remain to be unsatisfactory, new therapeutic approaches are needed. Circular RNA is a promising class of therapeutic RNAs. Recent studies have shown the role of circRNA in the pathologic process of epilepsy.

The Clinical Characteristics, Patterns of Recurrence, and Long-Term Survival Outcomes of Dual-Phenotype Hepatocellular Carcinoma After Curative Liver Resection.

Background & Aims: Dual-phenotype hepatocellular carcinoma (DPHCC) is discernible from classical HCC (CHCC) in its morphology and is characterized by the co-expression of both CHCC and cholangiocyte markers. This study aimed to clarify the difference between DPHCC and CHCC after surgery.

Methods: Patients with HCC after surgery were collected.

Progesterone affects periodontitis in perimenopausal women and in an experimental rat model.

Background/purpose: Progesterone (PG) is sex steroid hormone that commonly used to control menopausal symptoms, but its exact role in periodontitis remains unclear. This study aimed to investigate the effects of PG on periodontitis in perimenopausal women and in an experimental rat model.

Materials And Methods: Total 412 perimenopausal women with periodontitis and a history of PG deficiency-induced uterine dysfunctional bleeding were enrolled, among which 209 women had been treated with PG.

Ursolic acid attenuates pseudo-allergic reactions via reducing MRGPRX2-mediated mast cell degranulation.

Mas-related G protein-coupled receptor X2 (MRGPRX2) is a newly identified receptor on mast cells that contribute to IgE-independent pseudo-allergy. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported for its anti-allergy effects. However, the protective mechanism against pseudo-allergic reactions remains unclear.

Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family.

The cause of asthenozoospermia (AZS) is not well understood because of its complexity and heterogeneity. Although some gene mutations have been identified as contributing factors, they are only responsible for a small number of cases. Radial spokes (RSs) are critical for adenosine triphosphate-driven flagellar beating and axoneme stability, which is essential for flagellum motility.

Multicenter propensity score-matched analysis to compare perioperative morbidity after laparoscopic or robotic complex hepatectomy for solitary hepatocellular carcinoma.

Background: Postoperative complications are vital factors affecting the prognosis of patients with hepatocellular carcinoma (HCC), especially for complex hepatectomy. The present study aimed to compare perioperative complications between laparoscopic and robotic complex hepatectomy (LCH vs. RCH).

Preoperative Antiviral Therapy and Long-Term Outcomes for Hepatitis B Virus-Related Hepatocellular Carcinoma After Curative Liver Resection: A Multicenter Analysis.

Background & Aims: To examine the association of the history of preoperative antiviral therapy (AVT) with the tumor recurrence and overall survival in HBV-related HCC patients undergoing curative-intent hepatectomy.

Methods: Patients who underwent curative-intent hepatectomy for HBV-related HCC between 2014 and 2019 at 4 Chinese hospitals were analyzed. Patients were categorized as having undergone preoperative antiviral therapy (AVT) > 1 year or without antiviral therapy (non-AVT).

Homochiral and Heterochiral Self-Sorting Assemblies of Antiaromatic Ni(II) Norcorrole Dimers.

Recently, π-π stacked antiaromatic π-systems have received considerable attention because they can exhibit stacked-ring aromaticity due to substantial intermolecular orbital interactions. Here, we report three antiaromatic norcorrole dimers that self-assemble to form supramolecular architectures through chiral self-sorting. A 2,2'-linked norcorrole dimer with 3,5-di-tert-butylphenyl groups forms a π-stacked dimer both in solid and solution states via homochiral self-sorting.

Adrenomedullin improved endothelial dysfunction via receptor-Akt pathway in rats with obesity-related hypertension.

Obesity-related hypertension (OH) is accompanied by obvious endothelial dysfunction, which contributes to increased peripheral vascular resistance and hypertension. Adrenomedullin (ADM), a multifunctional active peptide, is elevated in obese humans. The OH rats induced by high fat diet (HFD) for 28 weeks and the human umbilical vein endothelial cells (HUVECs)-treated by palmitic acid (PA) were used to investigate the effects of ADM on endothelial dysfunction and the underlying mechanisms.

Survival benefit from adjuvant TACE combined with lenvatinib for patients with hepatocellular carcinoma and microvascular invasion after curative hepatectomy.

Background And Aims: The prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy is unsatisfactory, especially for those with microvascular invasion (MVI). This study aimed to determine the impact of adjuvant transcatheter arterial chemoembolization (TACE) and Lenvatinib on the prognosis of patients with HCC and MVI after hepatectomy.

Methods: Patients diagnosed with HCC and MVI were reviewed, and stratified into four groups according to adjuvant TACE and/or Lenvatinib.

[Age-dependent expression of HSP90 in the hippocampus of APP/PS1 mice].

The present study aims to observe the change in expression of heat shock protein 90 (HSP90) along with amyloid-β (Aβ) and phosphorylated Tau (p-Tau) protein levels in the hippocampus tissue of Alzheimer's disease (AD) transgenic animal model with age. APP/PS1 transgenic mice at age of 6-, 9- and 12-month and C57BL/6J mice of the same age were used. The cognitive abilities of these animals were evaluated using a Morris water maze.