α-Cyclodextrin mediated 3D printed ceramic/polymer composite scaffolds for immunomodulation and osteogenesis in bone defect repair.

Bone tissue engineering scaffolds for bone defect treatment face numerous challenges, including mechanical mismatches and the lack of immune microenvironment modulation, often leading to implant failure. In this study, an innovative drug-loaded bioinspired ceramic/polymer composite scaffold was designed and fabricated using extrusion-based 3D printing technology, incorporating α-cyclodextrin (αCD) in a novel approach to improve interfacial compatibility and drug-loading efficiency. Hydroxyapatite (HA), the main component of natural bone, was employed as the inorganic phase to mimic the mineral structure of bone tissue.

Encompassing Synthetic Methods to Modification Strategies: Cu-MOF-Derived Electrocatalysts for Enhancing CO Reduction.

To address the global climate challenge, carbon emissions reduction and carbon neutrality have emerged as pivotal goals for the international community. Copper-based metal-organic framework (Cu-MOF) derivatives exhibit unique advantages in electrocatalytic carbon dioxide reduction reaction (CORR) applications due to their controllable pore structure, abundant active sites, and efficient charge transport. Nevertheless, the structure-activity correlation mechanisms and performance enhancement methodologies of Cu-MOF derivatives have not yet been comprehensively elucidated in existing literature.

Ablation of Steroidogenic Superoxide Dismutase 2 Increases Oxidative Stress and Diminishes Steroid Hormone Production.

Mitochondria are a major source of reactive oxygen species, such as superoxide anion (O2●─), contain the enzyme complexes of the electron transport chain and, in steroidogenic tissues, steroid hormone synthesizing P450 enzymes. Superoxide dismutase 2 (SOD2) is the main antioxidant enzyme localized in mitochondria for protection from oxidative insult by enzymatically converting O2●─ into H2O2, which is further degraded into H2O and O2. Although expressed at high levels in steroidogenic tissues and transcriptionally regulated by trophic hormones, SOD2's role in the regulation of steroid hormone production is not fully explored.

Interferon-responsive HEVs drive tumor tertiary lymphoid structure formation and predict immunotherapy response in nasopharyngeal carcinoma.

The outcome of immune checkpoint blockade (ICB) therapy largely hinges on the antitumor immunity of tertiary lymphoid structures (TLSs), but drivers of tumor TLS formation remain exclusive. By integrating spatial transcriptomics and a pan-cancer single-cell atlas, we reveal the characteristics of TLSs in nasopharyngeal carcinoma (NPC) and identify a subset of interferon-responsive high endothelial venules (IFN-HEVs) that links to the emergence of tumor-specific chemokines, especially CXCL9. Functionally, CXCL9-secreting IFN-HEVs are associated with the recruitment of CXCR3CD4 T cells into TLSs.

Suppressor of cytokine signaling 2 modulates regulatory T cell activity to suppress liver hepatocellular carcinoma growth and metastasis.

Background: Liver hepatocellular carcinoma (LIHC) is a highly aggressive cancer with poor prognosis due to its complex tumor microenvironment (TME) and immune evasion. Regulatory T cells (Tregs) play a critical role in tumor progression. Suppressor of cytokine signaling 2 (SOCS2), a key immune regulator, may modulate Treg activity and impact LIHC growth and metastasis.

Alterations of gut microbiota for the onset and treatment of psoriasis: A systematic review.

Psoriasis is a chronic, recurrent and systemic inflammatory skin disease which is mediated by immunoreaction. Its pathogenesis is multifactorial, and the exact driving factor remains unclear. Recent studies showed that gut microbiota, which maintain immune homeostasis of our bodies, is closely related with occurrence, development and prognosis of psoriasis.

Effects of cooperative learning on undergraduate nursing students: a quasi- experimental study.

Aim: This study evaluated the effect of cooperative learning on the attitude, satisfaction, and performance of undergraduate nursing students enrolled in community nursing courses.

Design: A one-group pretest-posttest quasi-experimental design.

Methods: This study was conducted at a university in northern Taiwan.

EGFR tyrosine kinase inhibitor ZZC4 overcomes acquired resistance to gefitinib.

Despite the tremendous progress of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) development, acquired resistance mechanisms have limited their efficacy in treating non-small cell lung cancer (NSCLC). To overcome these limitations, novel EGFR-TKIs are needed. In our previous study, we presented ZZC4 as a potent EGFR-TKI.

Lactate-triggered histone lactylation contributes to podocyte epithelial-mesenchymal transition in diabetic nephropathy in mice.

Diabetic nephropathy (DN) closely relates to morphological and functional changes of podocytes, and anaerobic glycolysis represents the predominant energy source of podocytes. However, it is unknown whether lactate accumulation in chronic high glucose causes epithelial-mesenchymal transition (EMT) of podocytes through lactate-derived histone lysine lactylation (HKla). Lactate levels increased in high glucose-stimulated mouse podocyte cell line MPC and blood and the kidney of diabetic mice.

"Bis-Clamp-Cavity Synergy", an Efficient Approach to Improve Guest Binding Properties of Macrocyclic Host and Its Application on Detection of Al and Arg in Living Cells.

Improving the selective and sensitive binding properties of macrocyclic hosts to target guests is always an interesting challenge. Herein, we introduce a novel "bis-clamp-cavity synergy" strategy to enhance the selectivity and binding sensitivity of pillararenes toward target guests. To achieve this goal, we designed and synthesized ,'-bis-hydroxynaphthoylhydrazone-functionalized conjugated pillar[5]arene (), in which bis-hydroxynaphthoylhydrazone plays the role of clamps, while the pillar[5]arene provides the macrocyclic cavity.

Ursolic acid attenuates pseudo-allergic reactions via reducing MRGPRX2-mediated mast cell degranulation.

Mas-related G protein-coupled receptor X2 (MRGPRX2) is a newly identified receptor on mast cells that contribute to IgE-independent pseudo-allergy. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported for its anti-allergy effects. However, the protective mechanism against pseudo-allergic reactions remains unclear.

Novel therapeutic regimens against : an updated systematic review.

() is a strict microaerophilic bacterial species that exists in the stomach, and infection is one of the most common chronic bacterial infections affecting humans. Eradicating is the preferred method for the long-term prevention of complications such as chronic gastritis, peptic ulcers, gastric mucosa-associated lymphoid tissue lymphoma, and gastric cancer. However, first-line treatment with triple therapy and quadruple therapy has been unable to cope with increasing antibacterial resistance.

Sodium sulfite-driven Helicobacter pylori eradication: Unraveling oxygen dynamics through multi-omics investigation.

Due to the emergence and spread of multidrug resistance in Helicobacter pylori (H. pylori), its eradication has become difficult. Sodium sulfite (SS), a widely used food additive for ensuring food safety and storage, has been recognized as an effective nonbactericidal agent for H.

Anticancer effect of covalent purine-containing EGFR TKI, ZZC4 and its mechanism of action through network pharmacology.

Aims: Epidermal growth factor receptor (EGFR) has been documented in many malignancies as participating in the progression of cancer cells. Here, we present a novel EGFR tyrosine kinase inhibitor, ZZC4, and examine its effect on cancer cell proliferation, migration, and tumor-bearing xenograft models.

Main Methods: The antiproliferative effect of ZZC4 was assessed in vitro by MTT assay, colony formation, and wound healing assay and in vivo with tumor-bearing xenograft nude mice.

ITRAQ-based proteomics analysis of human ectopic endometrial stromal cells treated by Maqian essential oil.

Background: Endometriosis is a common and complex syndrome characterized by the presence of endometrial-like tissue outside the uterus. Chinese medicine has been recently found to show good efficacy in treating endometriosis. Our previous results revealed that Maqian fruit essential oil (MQEO) could inhibit the proliferation and induce apoptosis of ectopic endometrial stromal cells (EESCs), but the mechanisms remain unclear.

The gut microbiota metabolite butyrate mitigates MPTP/MPP -induced Parkinson's disease by inhibiting the JAK2/STAT3 signaling pathway.

Butyrate (BU), a gut microbiota-derived metabolite, has been reported to play a neuroprotective role in Parkinson's disease (PD). However, the specific molecular mechanism of BU has not been fully interpreted. This work aimed to verify the protective effects of BU against MPTP/MPP -induced neurotoxicity and explore the mechanisms involved.

mutation of ()related early-onset progressive encephalopathy with brain edema and/or leukoencephalopathy-1: A case report.

Background: Early-onset progressive encephalopathy with brain edema and/or leukoencephalopathy-1 (PEBEL1) is a rare autosomal recessive severe neurometabolic disease. The aim of this study was to investigate the clinical characteristics and genetic pathogenicity of PEBEL1 caused by rare (or )-related defects.

Case Summary: The patient was a girl aged 2 years and 10 mo.

The effects of sodium sulfite on Helicobacter pylori by establishing a hypoxic environment.

Helicobacter pylori (H. pylori) is an obligate microaerobion and does not survive in low oxygen. Sodium sulfite (SS) reacts and consume oxygen in solutions.

Characterization of CM-Dil-labeled Muse cells in culture and in skin wounds in rats.

To investigate the characteristics of multilineage-differentiating stress-enduring (Muse) cells labeled with chloromethyl dialkylcarbocyanine (CM-Dil) in culture and in skin wounds of rats. Normal human dermal fibroblasts (NHDFs) were obtained from foreskins and were confirmed by immunocytochemistry with vimentin. Muse cells were derived from NHDFs using long-term trypsinization (LTT), were confirmed using immunocytochemistry with antibodies against stage specific embryonic antigen-3 (SSEA-3) and CD105 and were expanded in suspension cultures.

In Vitro Inhibitory Effects of Maqian Essential Oil against Ectopic Endometrial Stromal Cells and LPS-Induced Endometrial Epithelial Cells.

Previous studies revealed that MQEO (Maqian fruits essential oil), which is extracted from the fruit of Maqian (Zanthoxylum myriacanthum var. Pubescens), had a good anti-inflammatory effect, but the effect on endometriosis in vitro remains unknown. In the present study, the inhibitory effects of MQEO against the EESCs (ectopic endometrial stromal cells) were investigated.

Role of Cell-Cell Junctions in Oesophageal Squamous Cell Carcinoma.

Cell-cell junctions comprise various structures, including adherens junctions, tight junctions, desmosomes, and gap junctions. They link cells to each other in tissues and regulate tissue homeostasis in critical cellular processes. Recent advances in cell-cell junction research have led to critical discoveries.