Meta-analysis of the safety and efficacy of fresh frozen plasma exchange in the treatment of organophosphate pesticide poisoning.

This study evaluates whether fresh frozen plasma (FFP) improves outcomes compared to conventional therapy alone in organophosphorus poisoning (OP). Relevant literature was searched in PubMed, Web of Science, Embase, Cochrane Library, CNKI, Wanfang, and VIP databases, applying predefined inclusion/exclusion criteria to select studies. Data from included studies were extracted for analysis.

Antigenicity analysis of the recombinant outer membrane NlpI protein of Mannheimia haemolytica.

To explore the antigenic characteristics of the NlpI protein. This study screened a potential antigen of Mannheimia haemolytica using NCBI Blast analysis and investigated its immunogenicity using online software. The recombinant NlpI protein (rNlpI) was expressed in prokaryotic cells, and its reactogenicity was detected by western blot.

Inhibition of the ATP synthase c subunit ameliorates HDM/LPS-induced inflammatory responses in asthmatic bronchial epithelial cells by blocking the mPTP-mtDNA-cGAS-STING axis.

The ATP synthase c subunit (c subunit) constitutes the mitochondrial permeability transition pore (mPTP). The extended opening of the mPTP is crucial in the development of various human illnesses. Nevertheless, it remains unclear whether the c subunit regulates the prolonged opening of the mPTP to attenuate inflammatory responses in asthma.

Association of Physical Frailty With Incidence and Life Expectancy of COPD: A Population-Based Cohort Study.

Background: The bidirectional relationship between frailty and COPD is documented. However, longitudinal studies examining the combined effects of genetic predisposition and preserved ratio impaired spirometry (PRISm) on frailty in COPD development are lacking.

Research Question: What is the association between physical frailty and the incidence and mortality of COPD, and how do genetic predisposition and PRISm modify this association?

Study Design And Methods: We included 412,351 adults without COPD (mean age ± SD, 56.

Inhaled pH-Responsive polymyxin B-loaded albumin nanoparticles against pneumonia caused by carbapenem resistant .

The pneumonia induced by carbapenem resistant (CRKP) has high morbidity and mortality. Among the antibiotics currently available, polymyxin B (PMB) is considered to be the last line of defense. Routine intravenous administration of PMB has many problems, such as severe neurotoxicity and nephrotoxicity.

Efficacy and safety of cone-beam computed tomography-guided bronchoscopy for peripheral pulmonary lesions: a systematic review and meta-analysis.

Background: Cone-beam computed tomography (CBCT)-guided bronchoscopy is increasingly utilized for diagnosing peripheral pulmonary lesions (PPLs). We carried out the meta-analysis for assessing the efficacy and safety of CBCT-guided bronchoscopy for PPLs.

Methods: An extensive search in several databases was conducted to identify relevant articles.

PRAME Expression in Melanoma is Negatively Regulated by TET2-Mediated DNA Hydroxymethylation.

Preferentially expressed Antigen in Melanoma (PRAME) and Ten-Eleven Translocation (TET) dioxygenase-mediated 5-hydroxymethylcytosine (5hmC) are emerging melanoma biomarkers. We observed an inverse correlation between PRAME expression and 5hmC levels in benign nevi, melanoma in situ, primary invasive melanoma, and metastatic melanomas via immunohistochemistry and multiplex immunofluorescence: nevi exhibited high 5hmC and low PRAME, whereas melanomas showed the opposite pattern. Single-cell multiplex imaging of melanoma precursors revealed that diminished 5hmC coincides with PRAME upregulation in premalignant cells.

D-MGDCN-CLSTM: A Traffic Prediction Model Based on Multi-Graph Gated Convolution and Convolutional Long-Short-Term Memory.

Real-time and accurate traffic forecasting aids in traffic planning and design and helps to alleviate congestion. Addressing the negative impacts of partial data loss in traffic forecasting, and the challenge of simultaneously capturing short-term fluctuations and long-term trends, this paper presents a traffic forecasting model, D-MGDCN-CLSTM, based on Multi-Graph Gated Dilated Convolution and Conv-LSTM. The model uses the DTWN algorithm to fill in missing data.

Diagnostic Accuracy of FEF for Bronchial Hyperresponsiveness in Patients with Suspected Asthma and/or Allergic Rhinitis: A Systematic Review and Meta-analysis.

Background: Some studies have suggested that the forced expiratory flow between 25 and 75% of vital capacity (FEF) can be used as an early marker of bronchial hyperresponsiveness (BHR) in asthma and allergic rhinitis (AR), but is highly variable. Here, we aimed to assess whether the FEF can be used to diagnose BHR in patients with asthma-like symptoms and AR.

Methods: PubMed, EMBASE, Web of Science, Wiley Online Library, Cochrane Library, SinoMed, CNKI, and Wanfang Data were searched to acquire eligible studies.

Clinical value of serum LncRNA MIAT in early diagnosis and prognosis assessment of traumatic brain injury.

Objective: This study aims to explore the clinical significance of long non-coding RNA, myocardial infarction-associated transcript (MIAT), in patients with traumatic brain injury (TBI).

Methods: Retrospective inclusion of TBI patients meeting clinical criteria with complete data, alongside healthy controls. RT-qPCR was used to detect the expression of the serum MIAT.

Construction of a risk prediction model of diquat poisoning based on clinical indicators.

This study aims to explore the clinical characteristics and prognostic factors in patients with diquat (DQ) poisoning and to develop a clinical risk assessment model to improve diagnosis and treatment strategies. Data from 60 patients with DQ poisoning, including basic characteristics, poisoning severity, and inflammatory response indicators, were collected. The plasma concentration of DQ was measured using liquid chromatography-mass spectrometry.

Dose Optimization of Fluconazole After Initial Treatment Failure in Pulmonary Cryptococcosis in an Obese Patient with Type 2 Diabetes and Cirrhosis: A Case Report.

Background: Pulmonary cryptococcosis is a fungal infection of the lungs, particularly challenging to treat in patients with multiple comorbidities such as obesity, type 2 diabetes, and cirrhosis. Fluconazole is a first-line medication for the treatment of pulmonary cryptococcosis, but currently there is a lack of clinical medication experience in obese patients with multiple comorbidities, especially in dose adjustment after treatment failure.

Case Introduction: This case report describes the experience of fluconazole in the treatment of pulmonary cryptococcal infection in a 45-year-old Chinese male with obesity, type 2 diabetes, and cirrhosis.

Tigecycline combined with bronchoscopic interventions in the treatment of macrolide-unresponsive pneumonia: A case report.

(MP) is a common etiological agent of community-acquired pneumonia. However, there has been an increasing incidence of macrolide-unresponsive pneumonia (MUMPP) in recent years. The treatment of MUMPP requires further investigation.

Omadacycline for Diverse Infections in China: A Real-World Analysis of Efficacy and Safety.

Introduction: The efficacy and safety of omadacycline have been primarily documented through Phase III clinical trials; however, there are limited data from real-world clinical settings. This study aims to explore the real-world use of omadacycline in China and identify the factors associated with its efficacy.

Methods: We conducted a retrospective review of medical records for patients treated with omadacycline at a single center from March 2022 to March 2024.

Limb circumference measurements contributing to the diagnosis of snake venom-induced compartment syndrome.

Background: The present study aimed to investigate the relationship between swollen limb circumference and compartment pressure after a snakebite and to evaluate the diagnostic value of the circumference difference between the healthy and affected sides and the circumference growth rate for snake venom-induced compartment syndrome (CS).

Method: The study was based on a prospective cohort study of snakebite patients at the emergency department of West China Hospital from May 2021 to October 2022. The snakebite patients were divided into the CS and non-compartment syndrome (NCS) groups.

Prediction model of death risk in patients with sepsis and screening of biomarkers for prognosis of patients with myocardial injury.

This study aimed to create a robust prediction model for sepsis patient mortality and identify key biomarkers in those with myocardial injury. A retrospective analysis of 261 sepsis inpatients was conducted, with 44 deaths and 217 recoveries. Key factors were assessed via univariate and multivariate analyses, revealing myocardial injury, shock, and pulmonary infection as independent mortality risk factors.

Facile Method for Determining Lanthipeptide Stereochemistry.

Lanthipeptides make up a large group of natural products that belong to the ribosomally synthesized and post-translationally modified peptides (RiPPs). Lanthipeptides contain lanthionine and methyllanthionine bis-amino acids that have varying stereochemistry. The stereochemistry of new lanthipeptides is often not determined because current methods require equipment that is not standard in most laboratories.

Comparison of drug concentrations in blood and gastric lavage fluid before and after gastric lavage: A case report.

Background: Gastric lavage (GL) is one of the most important early therapies to remove unabsorbed toxins from the gastrointestinal tract. However, the details of performing gastric lavage remain to be established. There is controversy in clinical practice regarding individual choice of the timing of GL and its efficiency.

Application of nafamostat mesylate for anticoagulation in hemoperfusion therapy in patients with bromadiolone poisoning: Case reports.

Bromadiolone, as a second-generation coumarin anticoagulant rodenticide, may accidently cause harm to humans and non-target animals when overused or misused due to its high toxicity and long-lasting effects. In some severe cases such as the presence of active bleeding, treatment should involve the administration of hemoperfusion therapy. Nafamostat mesylate is a synthesized protease inhibitor that inhibits most factors in the coagulation process, preventing clotting and ensuring smooth blood flow during the procedure.

mA methylation: a potential key player in understanding and treating COVID-2019 infection.

Since its discovery in 2019, coronavirus disease 2019 (COVID-2019) spans a wide clinical spectrum from the asymptomatic stage, mild infection, to severe pneumonia. In patients with COVID-2019, factors such as advanced age, diabetes, or hypertension are associated with a significantly increased risk of severe diseases and death. Of note, the mechanisms underlying differences in the risk and symptoms of COVID-2019 among different populations are still poorly characterized.

An unusual case of abdominal pain: psychogenic vomiting complicated by spontaneous pneumomediastinum.

Background: Spontaneous pneumomediastinum (SPM) was defined by the appearance of free air in the mediastinum that was not preceded by trauma, surgery, or other medical procedures. Among the numerous manifestations of SPM, abdominal pain had seldom been described.

Case Presentation: A 25-year-old man presented to the emergency department with nausea, vomiting, and abdominal pain for 7 days.

Risk factors of multidrug-resistant bacteria infection in patients with ventilator-associated pneumonia: A systematic review and meta-analysis.

Background: Multidrug-resistant (MDR) bacteria-induced VAP often has high lethality. We present this systematic review and meta-analysis to assess the risk factors for MDR bacterial infection in patients with VAP.

Methods: PubMed, EMBASE, Web of Science, and Cochrane Library were searched for studies regarding MDR bacterial infection in VAP patients, from Jan 1996 to Aug 2022.