P-type buried layer DTSCR with predicted improved overshoot performance and discharge ability for ESD protections of advanced nanotechnology.

A novel P-type Buried Layer Diode-Triggered Silicon-Controlled Rectifier (PBL-DTSCR) with predicted good performance in electrostatic discharge (ESD) protection is proposed in this work. With P-type ESD implantations and silicide blocking layers applied to this novel structure, the efficiency of the diode triggering path is greatly improved, thus enhancing the discharge efficiency of the main path. Moreover, the parasitic SCR path is minimized by replacing the PNPN structure in conventional DTSCR to PNPNPN structure in PBL-DTSCR.

Research on a General SER Rate Prediction Model Based on a Set of Configuration Parameters Related to SER.

This article comprehensively analyzes the new developments and challenges faced by several typical prediction models in the field of radiation effects in recent years. The models discussed include the RPP model, the extended RPP (rectangular parallelepiped) model, and the IRPP (integral rectangular parallelepiped) model. The article conducts a comprehensive analysis of the limitations of the assumption that uses the linear energy transfer (LET) of incident particles and the SEU (single-particle upset) cross-section (without considering the energy and type of ions) to predict the rate of single-particle effects (SEUs).

A Review of Tunnel Field-Effect Transistors: Materials, Structures, and Applications.

The development of an integrated circuit faces the challenge of the physical limit of Moore's Law. One of the most important "Beyond Moore" challenges is the scaling down of Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) versus their increasing static power consumption. This is because, at room temperature, the thermal emission transportation mechanism will cause a physical limitation on subthreshold swing (), which is fundamentally limited to a minimum value of 60 mV/decade for MOSFETs, and accompanied by an increase in off-state leakage current with the process of scaling down.

Pharmacovigilance and signal detection of adverse drug events associated with proteasome inhibitors in multiple myeloma: a real-world analysis using the FAERS database.

Background: Proteasome inhibitors (PIs) such as Bortezomib, Carfilzomib, and Ixazomib have significantly improved outcomes in multiple myeloma (MM), but their real-world safety profiles require further exploration.

Objective: To assess adverse drug events (ADEs) associated with Bortezomib, Carfilzomib, and Ixazomib in MM patients using the FDA Adverse Event Reporting System (FAERS), and to identify new ADE signals not listed in product labels.

Methods: A total of 47,310 ADE reports (Bortezomib: 23,843; Carfilzomib: 9,835; Ixazomib: 13,632) were analyzed from FAERS (2004 - Q4 2024).

Gender differences in drug-induced precocious puberty: a real-world analysis of adverse event reports from the FDA FAERS database (2004-2024).

Background: Precocious puberty (PP) is the early onset of secondary sexual characteristics before the typical age of puberty, which can be caused by hormonal imbalances or external factors, such as medications. Drug-induced precocious puberty (DIPP) has become a growing concern, particularly in pediatric populations. However, the impact of gender differences on DIPP risk and the challenges in drug safety assessments have not been fully explored.

Driving innovations in cancer research through spatial metabolomics: a bibliometric review of trends and hotspot.

Background: Spatial metabolomics has revolutionized cancer research by offering unprecedented insights into the metabolic heterogeneity of the tumor microenvironment (TME). Unlike conventional metabolomics, which lacks spatial resolution, spatial metabolomics enables the visualization of metabolic interactions among cancer cells, stromal components, and immune cells within their native tissue context. Despite its growing significance, a systematic and visualized analysis of spatial metabolomics in cancer research remains lacking, particularly in the integration of multi-omics data and the standardization of methodologies for comprehensive tumor metabolic mapping.

Curcumin combined with arsenic trioxide enhances autophagy and immune surveillance to inhibit immune escape in acute myeloid leukemia.

Background: Acute myeloid leukemia (acute myeloid leukemia, AML) is a type of malignant hematological tumor characterized by high incidence, high mortality, and high recurrence rates. Although chemotherapy, targeted therapy, and immunotherapy have achieved certain therapeutic effects in recent years, immune evasion by tumor cells remains a key factor in the relapse and refractoriness of AML. Current research suggests that arsenic trioxide (Arsenic Trioxide, ATO) can regulate autophagy and upregulate NKG2D ligands (NKG2D-L) on the surface of AML cells, while the NKG2D-NKG2D-L axis is negatively associated with AML immune evasion.

Signal Mining and Analysis of Drug-Induced Myelosuppression: A Real-World Study From FAERS.

IntroductionDrug-induced myelosuppression (DIM) is a serious side effect of several medications, particularly chemotherapy, immunosuppressants, and targeted therapies, which can lead to infections, anemia, and bleeding. While these drugs are effective, their adverse effects can disrupt treatment plans and reduce quality of life. However, early identification of DIM remains challenging, as many associated drugs do not explicitly list this risk, complicating clinical monitoring.

Drug-induced second tumors: a disproportionality analysis of the FAERS database.

Background: Drug-induced second tumors (DIST) refer to new primary cancers that develop during or after the treatment of an initial cancer due to the long-term effects of medications. As a severe long-term adverse event, DIST has gained widespread attention globally in recent years. With the increasing prevalence of cancer treatments and the prolonged survival of patients, drug-induced second tumors have become more prominent and pose a significant public health challenge.

Exploration of novel dipeptidyl peptidase-IV inhibitory tetrapeptide from walnut (Juglans sigillata) protein and its effect on diabetes-like phenotypes induced by high-sugar diet in Drosophila melanogaster.

Walnut protein was hydrolyzed by different enzymes, and bromelain protein hydrolysate (W-Bromelain) showed the highest dipeptidyl peptidase-IV (DPP-IV) inhibitory activity. W-Bromelain was fractionated, and three novel tetrapeptides (LPQF, LPSF, and VPFP) were identified. In vitro evaluation showed that LPQF exhibited the highest DPP-IV inhibitory activity with an IC value of 99.

Simulation study of biosensor based on germanium-based dual-source dopingless line-tunneling FET.

In this paper, we propose and investigate a biosensor based on germanium-based dual-source dopingless line-tunneling FET, which uses dielectric modulation to detect biomolecules. Dual source and line-tunneling structure improves open state current of the biosensor. The trench gate structure facilitates biomolecules filling and cavity etching while enhancing the tunneling area.

Interference between immune cells and insomnia: a bibliometric analysis from 2000 to 2023.

Background: Insomnia is a widespread sleep disorder that significantly affects the quality of life and contributes to immune dysfunction, which in turn leads to chronic diseases. Despite extensive research on sleep disturbances and immune modulation, the relationship between insomnia and immune responses remains underexplored.

Objectives: The primary objective of this study was to conduct a bibliometric analysis to explore the interaction between immune cells and insomnia, identifying key immune responses involved and their potential roles in the development of insomnia and associated comorbidities.

The Mechanisms and Therapeutic Implications of PI3K Signaling in Airway Inflammation and Remodeling in Asthma.

Bronchial asthma is a complex and heterogeneous disease with ongoing airway inflammation and increased airway responsiveness. Key characteristics of the disease include persistent airway inflammation, airway hyperresponsiveness, and airway remodeling. Asthma's chronic and recurrent characteristics contribute to airway remodeling and inflammation, which can exacerbate lung damage.

Dichlorvos poisoning caused chicken cerebellar autophagy and changes of Caecal microflora.

In order to explore the effects of acute dichlorvos exposure on cerebellar autophagy and cecal microbes in broilers and to analyze the relationship between autophagy-related genes and cecal microbes. Broilers were randomly divided into three groups (with 16 broilers in each group)and respectively given distilled water and dichlorvos (2.48 mg / kg, 11.

A Real-World Pharmacovigilance Analysis for Demethylation Drug: Findings from the FDA Adverse Event Reporting Database.

Introduction: The real-world safety profiles of the demethylating agents azacitidine and decitabine remain inadequately characterized despite their widespread clinical use. Both drugs are extensively employed for the treatment of hematologic malignancies such as myelodysplastic syndromes and acute myeloid leukemia. This study aimed to evaluate their adverse event profiles by leveraging data from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS) database.

A peptide from Boletus griseus-Hypomyces chrysospermus protects against hypertension and associated cardiac and renal damage through modulating RAAS and intestinal microbiota.

Hypertension is a major risk factor for many cardiovascular diseases, which can lead to kidney and heart disease, stroke, and premature death. Inhibiting angiotensin-converting enzyme (ACE) activity is an effective method to relieve hypertension. Previously, we screened an active peptide KYPHVF (KF6) from Boletus griseus-Hypomyces chrysospermus with excellent ACE inhibitory activity.

Research Hotspots and Trends of NK Cell Immunotherapy for Acute Myeloid Leukemia: A Bibliometric Analysis From 2000 to 2023.

Background: Natural killer (NK) cell immunotherapy has shown promising therapeutic potential for acute myeloid leukemia (AML), especially with advancements in chimeric antigen receptor-engineered NK cells (CAR-NK) and artificial intelligence (AI). Despite these developments, the field lacks comprehensive bibliometric analyses to identify research hotspots and trends, which could guide future precision treatments.

Methods: A bibliometric analysis of NK cell immunotherapy for AML was conducted using literature from 2000 to 2023 retrieved from the Web of Science Core Collection database.

Cancer phenomics research hotspots and development trends: a bibliometric analysis from 2000 to 2023.

The emerging field of cancer phenomics provides comprehensive insights into tumor heterogeneity, promoting advances in personalized oncology. This study explores current research hotspots and future development trends in cancer phenomics through a bibliometric analysis of research from 2000 to 2023. Using data from the Web of Science Core Collection, we analyzed 1260 publications to identify global contributions and collaborative networks.

Causal effects of vitamin D on leukemia risk: insights from two-sample Mendelian randomization analysis.

Background: vitamin D plays a crucial role in immune regulation, anti-inflammatory processes, and tumor suppression, but its relationship with leukemia risk remains unclear. This study aims to evaluate the causal relationship between vitamin D levels and the risk of different types of leukemia through a two-sample Mendelian randomization (MR) analysis. Methods: data from large-scale genome-wide association studies (GWAS) were used, and genetic variants associated with vitamin D were selected as instrumental variables.

Causal relationship between branched-chain amino acids and leukemia risk: insights from a two-sample Mendelian randomization study.

Background: Branched-chain amino acids (BCAAs), including leucine, isoleucine, and valine, are essential amino acids involved in protein synthesis, energy metabolism, and immune regulation. While BCAAs are known to influence cancer biology, their role in leukemia remains unclear. This study employs Mendelian randomization (MR) analysis to explore the causal relationship between BCAA levels and four leukemia subtypes: acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), chronic lymphocytic leukemia (CLL), and chronic myeloid leukemia (CML).

Impact of Total Ionizing Dose on Radio Frequency Performance of 22 nm Fully Depleted Silicon-On-Insulator nMOSFETs.

In this paper, the degradation mechanism of the RF performance of 22 nm fully depleted (FD) silicon-on-insulator nMOSFETs at different total ionizing dose levels has been investigated. The RF figures of merit (the cut-off frequency , maximum oscillation frequency ) show significant degradation of approximately 14.1% and 6.

Research Hotspots and Trends in Global Cancer immunometabolism:A Bibliometric Analysis from 2000 to 2023.

Background: Cancer poses a major global health challenge, and immunotherapy, known as the third revolution in cancer treatment, has brought new hope to patients. The emerging field of immunometabolism has further enhanced the safety and efficacy of immunotherapy. Over the past two decades, this field has rapidly evolved in oncology, leading to numerous significant findings.

Analysis of coupling effect between TID and SET in SOI Tri-Gate nanowire field-effect transistors.

This study investigates the response of nanowire field-effect transistors (NWFETs) to total ionizing dose (TID), single-event transient (SET), and their coupling effects in junctionless (JL), inversion (IM), and junctionless accumulation (AC) modes. The degradation of the three modes under irradiation and the effect of device bias configuration on the electrical properties of NWFETs are analyzed, and the different effects of SET on the three modes are compared. On this basis, the influence of TID on SET current generation and the charge collection mechanism are studied, and the changes in peak current, pulse width, and collected charge of transient current under different TIDs are compared.

Walnut peptide relieves hypertension and associated kidney and heart injury by regulating the renin-angiotensin-aldosterone system and intestinal microbiota.

Background: Hypertension is a chronic disease with high morbidity and mortality. Previously, we screened a walnut meal peptide FDWLR (PEP) with significant angiotensin-converting enzyme inhibitory activity. The present study further investigated the anti-hypertensive effects of PEP in vivo using spontaneously hypertensive rats.