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In this paper, we propose and investigate a biosensor based on germanium-based dual-source dopingless line-tunneling FET, which uses dielectric modulation to detect biomolecules. Dual source and line-tunneling structure improves open state current of the biosensor. The trench gate structure facilitates biomolecules filling and cavity etching while enhancing the tunneling area. The dopingless structure prevents the formation of mutant junctions and minimizes the effects of random dopant fluctuations. Simulation results show that the proposed biosensor demonstrates excellent performance, with a high switching ratio of 5.9 × 10, a maximum threshold voltage sensitivity of 3.1 V, a maximum open state current sensitivity of 2.8 × 10, a maximum average subthreshold swing (SS) sensitivity of 0.86, and the minimum average SS is 36.8 mv/decade. The proposed biosensor, exhibiting high sensitivity and low power consumption, holds significant application potential.
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http://dx.doi.org/10.1088/1361-6528/add303 | DOI Listing |
ACS Chem Neurosci
September 2025
Chemical and Biomolecular Engineering Dept, University of California, Los Angeles, Los Angeles, California 90095, United States.
Simulations in three dimensions and time provide guidance on implantable, electroenzymatic glutamate sensor design; relative placement in planar sensor arrays; feasibility of sensing synaptic release events; and interpretation of sensor data. Electroenzymatic sensors based on the immobilization of oxidases on microelectrodes have proven valuable for the monitoring of neurotransmitter signaling in deep brain structures; however, the complex extracellular milieu featuring slow diffusive mass transport makes rational sensor design and data interpretation challenging. Simulations show that miniaturization of the disk-shaped device size below a radius of ∼25 μm improves sensitivity, spatial resolution, and the accuracy of glutamate concentration measurements based on calibration factors determined .
View Article and Find Full Text PDFACS Sens
September 2025
Department of Pharmacy, The People's Hospital of Guangxi Zhuang Autonomous Region & Guangxi Academy of Medical Sciences, Nanning, Guangxi 530021, China.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder primarily characterized by cognitive decline and behavioral impairments, typically manifesting in the elderly and presenile population. With the rapid global aging trend, early diagnosis and treatment of AD have become increasingly urgent research priorities. The primary pathological features of AD include excessive accumulation of β-amyloid (Aβ) plaques, the formation of neurofibrillary tangles, and neuronal loss.
View Article and Find Full Text PDFFood Sci Biotechnol
October 2025
Department of Food Science and Biotechnology, Chung-Ang University, Anseong, Gyeonggi 17546 Republic of Korea.
[This corrects the article DOI: 10.1007/s10068-025-01850-x.].
View Article and Find Full Text PDFFood Sci Biotechnol
October 2025
Department of Food Science & Technology, Chungnam National University, Daejeon, 34134 Republic of Korea.
poses significant challenges in the food industry due to its resistance in harsh environments and its ability to form biofilms. Endolysins represent a promising solution for controlling in the food industry, with potential applications during both production and storage. This review discusses various endolysins that effectively inhibit , emphasizing their optimal conditions and potential uses in food products.
View Article and Find Full Text PDFRSC Adv
September 2025
Department of Chemical Engineering, Jashore University of Science and Technology Jashore 7408 Bangladesh
Bacterial detection is crucial for accurate clinical diagnostics and effective environmental monitoring. Particularly, , a pathogenic bacterium, can cause a wide range of infections, including meningitis, bloodstream infections, pneumonia, urinary tract infections, and wound or surgical site infections. Herein, a polypyrrole (PPy) functionalized TiCT -tin dioxide nanoparticle (SnO NPs) nanocomposite-based hybrid capacitive electrode for the electrochemical detection of ATCC 700603 is developed.
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