Immunization with Complete Freund's Adjuvant Reveals Trained Immunity-like Features in A/J Mice.

Background/objectives: Freund's adjuvants induce different immunomodulatory effects, but their underlying molecular mechanisms are unclear. In this study, we investigated whether the immune-stimulating effects of the complete Freund's adjuvant (CFA) involve the mechanisms of trained immunity (TI).

Methods: We examined bone marrow cells (BMCs) isolated from CFA-immunized A/J mice to address this question.

Homoharringtonine Inhibits CVS-11 and Clinical Isolates of Rabies Virus In Vitro: Identified via High-Throughput Screening of an FDA-Approved Drug Library.

Rabies, a viral encephalitis caused by rabies virus (RABV), is 100% fatal upon the onset of symptoms. Effective post-exposure prophylaxis (PEP) measures are available, but they are often difficult to access in low-income countries. WHO estimates about 59,000 deaths due to rabies globally, and the majority are contributed by developing countries.

Comparative study of intraocular pressure variation among healthy and diabetic individuals.

Background: Diabetes and glaucoma share several common risk factors and pathophysiological similarities. Elevated intraocular pressure, a key pathogenic feature of glaucoma and its progression, has been found to be influenced in diabetic patients. Furthermore, a link between poor glycemic control and increased intraocular pressure has been documented.

NCCD: A unique combination of MOF-scaffolded stable luminescent copper nanoclusters (Cu NCs) and carbon dots (Cdots) as a potent antimicrobial agent against Pseudomonas aeruginosa.

Bacterial biofilm infections cause huge cases of morbidity and mortality globally. Cells in bacterial biofilms can easily overcome host immune response and become resistant to conventional antibiotics. Hence, the concurrent issues of biofilm infections demand the urgent development of new therapeutic strategies other than the conventional antibiotic treatment.

Quantum error correction of qudits beyond break-even.

Hilbert space dimension is a key resource for quantum information processing. Not only is a large overall Hilbert space an essential requirement for quantum error correction, but a large local Hilbert space can also be advantageous for realizing gates and algorithms more efficiently. As a result, there has been considerable experimental effort in recent years to develop quantum computing platforms using qudits (d-dimensional quantum systems with d > 2) as the fundamental unit of quantum information.

Association of neutrophil-to-lymphocyte ratio and CRP with spirometry in COPD patients in North India.

Background: Patients with chronic obstructive pulmonary disease (COPD) who have high serum levels of C-reactive protein (CRP), a marker of low-grade systemic inflammation, exhibit reduced lung functions and a worse prognosis. The neutrophil-to-lymphocyte ratio (N/L ratio, NLR), obtained from a complete blood count, is an inexpensive and easily accessible inflammation marker. The NLR has proven useful in assessing the risk for patients with various cardiovascular conditions, different types of solid tumours, sepsis, and infectious diseases.

Waist circumference as a predictor for severity of liver fibrosis in non-alcoholic fatty liver disease patients.

Introduction: Non-alcoholic fatty liver disease (NAFLD) may in some cases progress to increasing grades of liver fibrosis and eventually cirrhosis. NAFLD patients often succumb to cardiovascular causes. Previous studies have linked visceral fat, a known cardiovascular risk factor, to NAFLD.

Metabolic Reprogramming in Response to Freund's Adjuvants: Insights from Serum Metabolomics.

Freund's adjuvants have been used in vaccine and autoimmune settings, and their effects can be overlapping or unique to each. While both incomplete Freund's adjuvants (IFA) and complete Freund's adjuvants (CFA) influence antibody and T cell responses, the robust T helper 1 cytokines induced by the mycobacterial components make CFA the powerful immunostimulating adjuvant. In these studies, the adjuvant effects are investigated in a select population of cells, and the changes, if any, with the metabolic alterations in the systemic compartment are unclear.

Comparison of Kettlebell and Cycling Exercise on Heart Rate Variability.

Background: Kettlebells, dating back to 1703 in Russia, offer a full-body workout for strength, endurance, and flexibility. They activate back and hip musculature, reduce low back injury risk, and improve postural coordination. Cycling induces muscle hypertrophy, guiding exercise prescription.

The utility of brain biomarkers in predicting survival and neurological outcomes in pediatric patients after cardiac arrest: A systematic review and meta-analysis.

Background: Cardiac arrest in children is associated with high morbidity and mortality, primarily due to neurological injury. Biomarkers linked to brain injury, released into circulation from compromised elements of the neurovascular unit, act as significant prognostic indicators in patients suffering from hypoxic-ischemic brain injury (HIBI) subsequent to the restoration of spontaneous circulation (ROSC) after pediatric cardiac arrest. The aim of this systematic review and meta-analysis is to evaluate the prognostic utility of brain injury biomarkers in predicting neurological outcomes and survival in patients following cardiac arrest in the pediatric population.

Sulfur-modified tea-waste biochar improves rice growth in arsenic contaminated soil and reduces arsenic accumulation.

Arsenic (As) is a non-essential carcinogenic metalloid and an issue of concern for rice crops. This study investigated the effects of sulfur-loaded tea waste biochar (TWB) due to modification with sodium sulfide (SSTWB) or thiourea (TUTWB) on As stress and accumulation in rice plants. The results showed that sulfur-modified TWB improved plant morphology compared to plants grown in As-contaminated soil alone.

Impact of Osteocalcin on Glycemic Regulation and Insulin Sensitivity in Type 2 Diabetes Mellitus Patients.

Background Type 2 diabetes mellitus (T2DM) is a worldwide health issue impacting millions of individuals. In recent years, bone has been identified as an endocrine organ that regulates glucose metabolism by the release of osteocalcin, an osteoblast-specific hormone, which affects fat accumulation and blood glucose levels. Osteocalcin has been associated with insulin sensitivity and glucose control.

Interplay of Adiponectin With Glycemic and Metabolic Risk Metrics in Patients With Diabetes.

Background Type 2 diabetes mellitus (T2DM) is characterized by low insulin production or resistance. Adiponectin, a hormone produced by adipocytes, is essential for regulating glucose metabolism and is correlated with insulin decrease. Aim The aim of this study is to estimate the levels of adiponectin in T2DM patients and their relationship with various metabolic markers (glycated hemoglobin (HbA1c), fasting blood sugar (FBS), fasting insulin, lipid profile, and anthropometric variables in an Indian cohort.

Association of High-sensitivity C-reactive Protein Level with Obese Normal individuals in North Indian Population.

Background: One of the major inflammatory markers, C-reactive protein (CRP), is often elevated in people who have had a heart attack, vascular problems, stroke, or sudden cardiac death. Obesity is associated with higher CRP levels because adipose tissue activates cytokines. Obesity and overweight increase the risk of heart disease, as does an elevated CRP level.

Anthropometry and blood biomarkers of diabetes and their possible association with obesity and metabolic syndrome.

Background: Diabetes, a rapidly increasing heterogeneous disorder, is closely linked to the epidemic of obesity and metabolic syndrome (MetS). At present, we do not understand completely the blood biomarkers, molecular aetiology, and role of lifestyle modification and interventions to combat diabetes hand in hand with obesity and the MetS epidemic.

Methods: To measure different anthropometric and blood biomarkers in pre-diabetic and diabetic patients, we collected data and blood samples from patients in a hospital OPD.

Non-invasive predictors to grade esophageal varices in liver cirrhosis patients.

Background: Portal hypertension commonly occurs due to liver cirrhosis, and esophageal varices (EV) is one of the major complications associated with it. The most common cause of death in liver cirrhosis is EV bleeding. Hence, GE screening for EV is required, which is an invasive procedure.

Synergistic interactions of nanoparticles and plant growth promoting rhizobacteria enhancing soil-plant systems: a multigenerational perspective.

Sustainable food security and safety are major concerns on a global scale, especially in developed nations. Adverse agroclimatic conditions affect the largest agricultural-producing areas, which reduces the production of crops. Achieving sustainable food safety is challenging because of several factors, such as soil flooding/waterlogging, ultraviolet (UV) rays, acidic/sodic soil, hazardous ions, low and high temperatures, and nutritional imbalances.

Association of heart rate variability and C-reactive protein in patients with depression.

Background: Depression has been shown to be correlated with cardiovascular (CV) morbidity and mortality. Inflammation and autonomic nervous system (ANS) dysfunction are possible causes. Numerous clinical studies have found an association between inflammatory pathways and the ANS.

An evaluation of arsenic contamination status and its potential health risk assessment in villages of Nadia and North 24 Parganas, West Bengal, India.

The present study was conducted to evaluate the arsenic (As) contamination and possible associated health hazards to exposed population in four villages of two districts (Nadia and North 24 Parganas) of West Bengal, India. The study included two villages each from Nadia (Jaguli and Kugacchi) and North 24 Parganas (Chamta and Byaspur) districts. Groundwater, surface water, soil, rice grains and rice-based food samples were collected from these villages.

A practical evaluation on integrated role of biochar and nanomaterials in soil remediation processes.

Soil decontamination and restoration continue to be a key environmental concern around the globe. The degradation of soil resources due to the presence of potentially toxic elements (PTEs) has a substantial influence on agricultural production, food security, and human well-being, and as a result, urgent action is required. PTEs pollution is not a threat to the agroecosystems but also a serious concern to human health; thereby, it needs to be addressed timely and effectively.

Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target.

Purpose: Beta 2-Adrenergic Receptor (β2-AR) is significantly overexpressed in various types of malignancies, which is associated with the worst prognosis. However, the role of β2-AR in oral cancer is not well identified. The present study aimed at investigating the β2-AR gene expression and its significance in relation with the clinicopathological features and overall survival of oral squamous cell carcinoma (OSCC) patients.

Comprehensive technological assessment for different treatment methods of leather tannery wastewater.

The leather-making process necessitates large amounts of water and consequently generates tons of liquid waste as leather tannery wastewater (TWW) is disposed of directly in the open environment. Open disposal of untreated TWW into the natural environment causes an accumulation of various polluting compounds, including heavy metals, dyes, suspended solids inorganic matter, biocides, oils, tannins, and other toxic chemicals. It thus poses potential hazards to the environment and human health.

Recent advances in arsenic mitigation in rice through biotechnological approaches.

Arsenic (As) is a major threat to the environment and human health due to its toxicity and carcinogenicity. Occurrence of alarming concentrations of As in water and soil leads to its bioaccumulation in crops which is a major health concern globally. Rice () is a staple food for a large population staying in As contaminated areas so, it is of utmost importance to reduce As levels in rice, especially grains.