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http://dx.doi.org/10.5603/cj.105362 | DOI Listing |
Acta Physiol (Oxf)
October 2025
Biomedical Engineering and Physics, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
Background: The cerebral circulation is continuously challenged by intravascular micrometer-sized particles that become trapped microvascular-emboli. These particles may include micro-thrombi, stiffened erythrocytes, and leukocytes, while also fat particles, air, and microplastics may cause microvascular embolism.
Review Scope: In this narrative review, we discuss these embolization processes and their acute and chronic consequences.
Circ Cardiovasc Imaging
September 2025
Division of Cardiology, Cook County Health, Chicago, IL (Y.G., R.D.).
Rev Cardiovasc Med
August 2025
Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, 530021 Nanning, Guangxi, China.
Coronary microvascular disease has been found to increase the incidence of the composite endpoint for cardiovascular events and affect coronary revascularization. Coronary microvascular disease is often accompanied by epicardial disease, and despite successful revascularization and optimal medications, coronary microvascular disease may lead to reduced exercise tolerance and worsening clinical symptoms. Moreover, despite advances in percutaneous coronary intervention for coronary revascularization, the management of microvascular obstruction in reperfused myocardial tissue remains challenging and is a high-risk procedure.
View Article and Find Full Text PDFRev Cardiovasc Med
August 2025
Cardiovascular Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences, 100091 Beijing, China.
Background: While the invasive index of microcirculation resistance (IMR) remains the gold standard for diagnosing coronary microvascular dysfunction (CMD), its clinical adoption is limited by procedural complexity and cost. Angiography-based IMR (Angio-IMR), a computational angiography-based method, offers a promising alternative. This study evaluates the diagnostic efficacy of Angio-IMR for CMD detection in angina pectoris (AP).
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Surgery, Heart Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, United States.
Protein kinases have crucial roles in intracellular signal transduction pathways that affect a wide range of biochemical processes, including apoptosis, metabolism, proliferation, and protein synthesis. Vascular endothelial cells are important regulators of vasomotor tone, tissue/organ perfusion, and inflammation. Since its discovery in the late 1970s, a growing body of literature implicates protein kinase C (PKC) in pathways involving angiogenesis, endothelial permeability, microvascular tone, and endothelial activation.
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