Publications by authors named "Shibin Lin"

Background: Fetal ventriculomegaly (VM) is a common congenital abnormality with poor outcomes in severe cases, the mechanisms of which include cerebrospinal fluid(CSF)circulation disorders and abnormal neural development. While Aquaporin 4 (AQP4) plays an important role in CSF circulation, its expression in fetal VM has not been fully studied.

Methods: Fetal goats at 90-100 days of gestation were divided into experimental (hydrocephalus induced by BioGlue ® injection) and control (untreated cotwin) groups.

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Fetal congenital heart disease (FCHD) represents a serious and prevalent congenital malformation. However, there exist notable regional disparities in the detection rates of fetal heart abnormalities. To enhance the diagnostic capabilities of ultrasound physicians in primary hospitals regarding fetal heart structures, the adoption of artificial intelligence technology to assist in acquiring high-quality, standard fetal echocardiographic images is of paramount importance.

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Aim: To elucidate the biological functionality and regulatory mechanisms of GdX in breast cancer (BC).

Methods: The examination of GdX expression in human BC tissues and cell lines was conducted through immunohistochemical (IHC) and Western blot. Cell proliferation capacity was assessed via the CCK-8 and colony formation assay, while cell migration was determined through the wound healing assay.

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Article Synopsis
  • * Recent studies have shown that ferroptosis is connected to eye diseases, including those related to aging, immunity, and cancer, highlighting its significance in ocular health.
  • * The article reviews advancements in understanding ferroptosis in the context of eye diseases and discusses potential future treatments involving natural compounds that could lead to new drug developments for ocular conditions.
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Purpose: To investigate the changes in refractive status after surgery in patients with horizontal strabismus and high refractive error.

Methods: This was a prospective study of patients with horizontal strabismus and high refractive error. The patients were divided into a horizontal rectus recession group (group 1) and a horizontal rectus recession combined with horizontal rectus resection group (group 2).

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Purpose: To determine the effects of strabismus on dry eye parameters.

Methods: In this cross-sectional study, the preliminary assessment of ocular parameters related to dry eye disease was performed in patients with untreated concomitant strabismus. In total, 204 patients with concomitant strabismus and 125 volunteers without strabismus (4 to 30 years old, 170 male and 159 female) were enrolled.

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Prenatal anterior mediastinal teratomas are rare. Anterior mediastinal teratomas can cause edema during the perinatal period. Color Doppler ultrasonography and chest computed tomography (CT) are of great value in diagnosing neonatal anterior mediastinal teratomas.

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To assess the effects of intense pulsed light (IPL) on oxidative stress (OS) in perennial allergic conjunctivitis (PAC). IPL treatment has been proven effective for dry eye disease (DED). However, we have observed that, after IPL treatment, some patients with DED combined with allergic conjunctivitis (AC), an immune response condition in which excessive OS causes and exacerbates inflammatory damage, not only show an improvement in eye dryness, but also their AC-related eye itching is relieved.

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To assess the inhibitory effects of intense pulsed light (IPL) on meibomian gland (MG) inflammation. IPL treatment is effective for dry eye disease (DED) caused by meibomian gland dysfunction (MGD). However, the anti-inflammatory and regeneration stimulating effects of IPL on MGD remain unclear.

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Objective: The purpose of this research was to observe the characteristics of atherosclerosis in diabetic patients by ultrasound and analyze the factors influencing the development of atherosclerosis in these patients.

Methods: Ninety diabetic patients treated in our hospital from January 2019 to December 2019 were enrolled in this retrospective analysis. The transcranial Doppler ultrasound (TCD) and carotid ultrasound were used to determine the presence of intracranial (stenosis) and extracranial (plaque) atherosclerosis.

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Background: To investigate the distribution pattern of strabismus surgery at an eye center in southern China.

Methods: The data of all patients who underwent strabismus surgery at the Joint Shantou International Eye Center of Shantou University /Chinese University of Hong Kong from 2014 to 2020 were retrospectively analyzed. The type of strabismus and its relationship with age and sex were analyzed, and the trend in the number of strabismus surgeries was observed.

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To evaluate the ocular biometric parameters in patients with constant and intermittent exotropia by the measurement of swept-source optical coherence tomography (SS-OCT) optical biometer OA-2000 and comparing it with the normal control subjects. Cross-sectional case-control study. Fifty-five constant and 24 intermittent patients with exotropia with central fixation and 77 orthotropic normal control participants aged 4-18 years old.

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Objective: To explore the pharmacological mechanism of Liuwei Dihuang decoction (LDD) for diabetic retinopathy (DR).

Methods: The potential targets of LDD were predicted by PharmMapper. GeneCards and other databases were used to collect DR genes.

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Objective: To investigate the clinical application values of electrocardiogram (ECG) combined with ultrasound cardiogram (UCG) in the differential diagnosis of cardiomyopathy.

Methods: A total of 120 patients with cardiomyopathy who were admitted to our hospital were randomly divided into the dilated cardiomyopathy (DCM) group (60 cases) and the ischemic cardiomyopathy (ICM) group (60 cases). Both groups were examined using ECG combined with UCG.

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To conduct a preliminary assessment of intense pulsed light (IPL) treatment for allergic keratoconjunctivitis (AKC)-associated ocular itch. Current control measures for AKC rely primarily on drugs. IPL is effective for dry eye disease (DED).

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Purpose: This study implements and demonstrates a deep learning (DL) approach for screening referable horizontal strabismus based on primary gaze photographs using clinical assessments as a reference. The purpose of this study was to develop and evaluate deep learning algorithms that screen referable horizontal strabismus in children's primary gaze photographs.

Methods: DL algorithms were developed and trained using primary gaze photographs from two tertiary hospitals of children with primary horizontal strabismus who underwent surgery as well as orthotropic children who underwent routine refractive tests.

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To conduct a preliminary assessment of the intense pulsed light (IPL) treatment on the upper eyelid. IPL therapy is an effective therapy for meibomian gland dysfunction (MGD). The normal treatment region includes the skin below the lower eyelids and both temporal parts, but not the upper eyelid.

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Ultrapulse CO laser has been used for several decades for removal of xanthelasma lesions. However, most studies to date have focused on Caucasian patients (skin types I-II). We sought to assess the efficacy and complications of CO laser therapy for xanthelasma palpebrarum (XP) in Chinese patients (skin types III-IV).

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Several cases of meibomian gland dysfunction (MGD), particularly the moderate to severe ones, are considered intractable by traditional therapy. Intense pulsed light (IPL) therapy has emerged as a new choice for management of MGD in recent years, given that use of lasers and optical treatments is typically challenging in patients with darker skin types. IPL treatment for MGD is administered in the periorbital area with the thinnest skin in our body, which has an inherent risk of skin side effects.

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Objective: Laser skin resurfacing (LSR) has been used for facial rejuvenation for the last 20 years. Posttreatment care after LSR is essential to decrease the risk of complications. Currently, no unified standards or criteria exist for invasive LSR posttreatment care.

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Background: For 20 years, intense pulsed light (IPL) technology has been used to treat various medical problems. IPL has since developed rapidly, becoming popular among patients worldwide. Recently, IPL has been used mainly for cosmetic purposes.

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Purpose: To study associations between strabismus and alcohol use, anxiety, and depression among 10- to 17-year-old children in Guangdong, southern China.

Design: Cross-sectional, population-based study.

Methods: Among 7537 children aged 6-17 years from 9 randomly selected primary and middle schools, ocular alignment was assessed with the Hirschberg light reflex, cover-uncover testing, and alternate cover testing at distance (6 m) and near (40 cm).

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Purpose: To study and analyze the correlation among corneal biomechanical properties and associated factors including central corneal thickness (CCT), corneal curvature (CT), and intraocular pressure (IOP) in school-age children.

Methods: A cross sectional investigation was conducted. An ocular response analyzer was utilized to assess the corneal biomechanical properties, such as corneal hysteresis and corneal resistance factors, in children of school age.

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Purpose: The antiseptic effectiveness of 5% anerdian III, 0.016% gentamicin, and 0.5% tobramycin solutions in pre-surgical irrigation of conjunctival sac were compared.

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