Development of Privacy-preserving Deep Learning Model with Homomorphic Encryption: A Technical Feasibility Study in Kidney CT Imaging.

. Purpose To evaluate the technical feasibility of implementing homomorphic encryption in deep learning models for privacy-preserving CT image analysis of renal masses. Materials and Methods A privacy-preserving deep learning system was developed through three sequential technical phases: a reference CNN model (Ref-CNN) based on ResNet architecture, modification for encryption compatibility (Approx-CNN) by replacing ReLU with polynomial approximation and max-pooling with averagepooling, and implementation of fully homomorphic encryption (HE-CNN).

PIBF1 expression and survival outcome in TNBC and Non-TNBC breast cancer patients with lymph node metastasis who undertaken chemotherapy.

Progesterone-induced blocking factor 1 (PIBF1) is linked to pregnancy-induced immunity and tumor evasion of maternal immunity. PIBF1 is overexpressed in several cancers, including breast, cervical, and lymphoma. However, limited research is available on the role of PIBF1 in breast cancer and its clinical outcomes.

Association between preoperative oxygen reserve index and postoperative pulmonary complications: a prospective observational study.

Background: The oxygen reserve index (ORi) noninvasively measures oxygen levels within the mild hyperoxia range. To evaluate whether a degree of increase in the ORi during preoxygenation for general anesthesia is associated with the occurrence of postoperative pulmonary complications (PPCs).

Methods: We enrolled 154 patients who underwent preoperative pulmonary function tests and were scheduled for elective surgery under general anesthesia.

Dynamic Task-Related Changes in Electroencephalography Brain Connectivity During a Button-Press Task in Children with and Without Bilateral Cerebral Palsy.

Cerebral palsy (CP) often affects function of one or both arms. Resting-state magnetic resonance imaging studies identified abnormal neuronal connectivity related to functional deficits in CP, with few studies on dynamic, task-related changes in connectivity. Here, we compare connectivity in participants with CP and typical development (TD) during an upper limb task and relate these to motor performance.

Nanoengineered hybrid hydrogel-based 3D nanocomposite as an antifouling coating interface for enhanced electrochemical aptasensing of estradiol.

Electrochemical biosensing has emerged as a promising method for the point-of-care detection of various biomarkers. However, its clinical application faces significant challenges due to biofouling when exposed to clinical samples. This study presents a novel nanocomposite coating aimed at addressing biofouling in electrochemical biosensors by developing an Electrochemical Estradiol Aptasensor (EAS).

Deintensification of radiation dose to 20 Gy for conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma.

This study evaluated the efficacy and safety of 20.0 Gy versus 30.6 Gy radiotherapy for conjunctival MALT lymphoma in 76 lesions treated between 2010 and 2022.

Predicting intraoperative hypoxemia in lung resection surgery: assessing the utility of oxygen reserve index measurements during one-lung ventilation before pleural opening.

One-lung ventilation (OLV) is crucial for collapsing the lung and improving access to the operative field during lung surgery. Intraoperative OLV may increase the intrapulmonary shunt, potentially leading to intraoperative hypoxemia. The Oxygen Reserve Index (ORI) is a continuous, noninvasive parameter that provides a broader range of oxygen reserve data than conventional oxygen saturation measurements.

HDAC6 inhibition upregulates endothelial SOD3 expression via Sp1 acetylation and attenuates angiotensin II-induced hypertension.

Extracellular superoxide dismutase (SOD3) plays an important role in maintaining vascular redox homeostasis by eliminating superoxides. The angiotensin II (AngII) peptide mediates vasoconstriction in part via reactive oxygen species (ROS) but has pathologic effects when elevated in adults. Histone deacetylase 6 (HDAC6) modulates the acetylation of non-histone substrates and is associated with hypertensive disorders.

Characteristics of transition to turbulence in a healthy thoracic aorta using large eddy simulation.

This study employed large eddy simulation (LES) with the wall-adapting local eddy-viscosity (WALE) model to investigate transitional flow characteristics in an idealized model of a healthy thoracic aorta. The OpenFOAM solver pimpleFoam was used to simulate blood flow as an incompressible Newtonian fluid, with the aortic walls treated as rigid boundaries. Simulations were conducted for 30 cardiac cycles and ensemble averaging was employed to ensure statistically reliable results.

Scalable InGaN nanowire µ-LEDs: paving the way for next-generation display technology.

Ever-increasing demand for efficient optoelectronic devices with a small-footprinted on-chip light emitting diode has driven their expansion in self-emissive displays, from micro-electronic displays to large video walls. InGaN nanowires, with features like high electron mobility, tunable emission wavelengths, durability under high current densities, compact size, self-emission, long lifespan, low-power consumption, fast response, and impressive brightness, are emerging as the choice of micro-light emitting diodes (µLEDs). However, challenges persist in achieving high crystal quality and lattice-matching heterostructures due to composition tuning and bandgap issues on substrates with differing crystal structures and high lattice mismatches.

TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner.

Objectives: Dysregulation of lipid homeostasis pathway causes many liver diseases, including hepatic steatosis. One of the primary factors contributing to lipid accumulation is fatty acid uptake by the liver. Transmembrane protein 135 (TMEM135), which exists in mitochondria and peroxisomes, participates in intracellular lipid metabolism.

Impact of Preanesthetic Blood Pressure Deviations on 30-Day Postoperative Mortality in Non-Cardiac Surgery Patients.

Background: Blood pressure readings taken before anesthesia often influence the decision to delay or cancel elective surgeries. However, the implications of these specific blood pressure values, especially how they compare to baseline, on postoperative in-hospital 30-day mortality remain underexplored. This research aimed to examine the effect of discrepancies between the baseline blood pressure evaluated in the ward a day before surgery, and the blood pressure observed just before the administration of anesthesia, on the postoperative mortality risks.

Predicting Delayed Postoperative Length of Stay Following Robotic Kidney Transplantation: Development and Simulation of Perioperative Risk Factors.

Early discharge following robot-assisted kidney transplantation (RAKT) is a cost-effective strategy for reducing healthcare expenses while maintaining favorable short- and long-term prognoses. This study aims to identify predictors of postoperative delayed discharge in RAKT patients and develop a predictive model to enhance clinical outcomes. This retrospective study included 146 patients aged 18 years and older who underwent RAKT at a single tertiary medical center from August 2020 to January 2024.

CD47;Rag2;IL-2rγ triple knock-out mice pre-conditioning with busulfan could be a novel platform for generating hematopoietic stem cells engrafted humanized mice.

Introduction: Humanized mouse models to recapitulate human biological systems still have limitations, such as the onset of lethal graft-versus-host disease (GvHD), a variable success rate, and the low accessibility of total body irradiation (TBI). Recently, mice modified with the CD47-SIRPA axis have been studied to improve humanized mouse models. However, such trials have been rarely applied in NOD mice.

Comparison of the Effects of Multiple Frailty and Nutritional Indexes on Postoperative Outcomes in Critically Ill Patients Undergoing Lung Transplantation.

: Lung transplantation is the only life-extending therapy for end-stage pulmonary disease patients, but its risks necessitate an understanding of outcome predictors, with the frailty index and nutritional status being key assessment tools. This study aims to evaluate the relationship between preoperative frailty and nutritional indexes and the postoperative mortality rate in patients receiving lung transplants, and to determine which measure is a more potent predictor of outcomes. This study reviewed 185 adults who received lung transplants at a single medical center between January 2013 and May 2023.

Development of a machine learning approach for prediction of red blood cell transfusion in patients undergoing Cesarean section at a single institution.

Despite recent advances in surgical techniques and perinatal management in obstetrics for reducing intraoperative bleeding, blood transfusion may occur during a cesarean section (CS). This study aims to identify machine learning models with an optimal diagnostic performance for intraoperative transfusion prediction in parturients undergoing a CS. Additionally, to address model performance degradation due to data imbalance, this study further investigated the variation in predictive model performance depending on the ratio of event to non-event data (1:1, 1:2, 1:3, and 1:4 model datasets and raw data).

Unveiling the distinctive mechanical and thermal properties of γ-GeSe.

γ-GeSe is a newly identified polymorph among group-IV monochalcogenides, characterized by a distinctive interatomic bonding configuration. Despite its promising applications in electrical and thermal domains, the experimental verification of its mechanical and thermal properties remains unreported. Here, we experimentally characterize the in-plane Young's modulus (E) and thermal conductivity ([Formula: see text]) of γ-GeSe.

Solar-Driven Sustainability: III-V Semiconductor for Green Energy Production Technologies.

Long-term societal prosperity depends on addressing the world's energy and environmental problems, and photocatalysis has emerged as a viable remedy. Improving the efficiency of photocatalytic processes is fundamentally achieved by optimizing the effective utilization of solar energy and enhancing the efficient separation of photogenerated charges. It has been demonstrated that the fabrication of III-V semiconductor-based photocatalysts is effective in increasing solar light absorption, long-term stability, large-scale production and promoting charge transfer.