Comparative Analysis of Vehicles for the Regeneration of Mouse Endometrial Damage Model.

Background: Endometrial damage is a critical factor contributing to infertility, particularly in women with refractory thin endometrium or intrauterine adhesions. Therefore, developing innovative therapeutic strategies for endometrial regeneration is essential. This study evaluates the regenerative potential of endometrial stromal cell (EMSC) injection and EMSC-loaded patch application in a mouse model with ethanol-induced endometrial damage.

Oral tryptophan supplementation to suckling piglets affecting hypothalamic serotonin metabolism, behavior, and growth in the nursery period under social mixing stress.

Tryptophan (Trp) is the rate-limiting substrate for the synthesis of serotonin (5-hydroxytryptamine; 5-HT) in the brain, which plays a central role in the regulation of stress sensitivity and feed intake. The objective of this study was to evaluate the effect of oral Trp supplementation to suckling piglets on 5-HT metabolism, growth performance, and behavior during the suckling (14 to 21 d of age) and nursery (21 to 56 d of age) periods, under social mixing stress at weaning. Eighty 14-day-old suckling piglets from 10 sows (8 piglets per litter) were allotted to 2 treatments.

Associations between traumatic brain injury and the prevalence of Alzheimer's disease dementia and behavioral and psychological symptoms of dementia: A retrospective cohort study.

Background: Traumatic brain injury is an environmental risk factor that may accelerate the progression of Alzheimer's disease and behavioral and psychological symptoms of dementia in patients with mild cognitive impairment.

Objectives: To investigate whether traumatic brain injury in patients with mild cognitive impairment is associated with an increased risk of progression to Alzheimer's disease dementia and behavioral and psychological symptoms of dementia.

Design: A retrospective cohort study using the Korean National Health Insurance Service database.

Effects of fermented rice bran extract with multi-microbial species on intestinal health and growth of nursery pigs.

Objective: The objective of this study was to investigate the effects of fermented rice bran extract (FRB) with multi-microbial species on intestinal health and growth performance of nursery pigs.

Methods: Thirty weaned pigs (initial body weight = 6.8±0.

Effect of aspirin use on conversion risk from mild cognitive impairment to Alzheimer's disease.

Background: The potential effect of the antiplatelet and anti-inflammatory properties of aspirin on Alzheimer's disease development, especially its role in the progression from mild cognitive impairment to Alzheimer's disease dementia, remains controversial. To evaluate the association between aspirin, use and the risk of conversion to Alzheimer's disease dementia among individuals diagnosed with mild cognitive impairment.

Methods: In this retrospective population-based cohort study, we used the Korean National Health Insurance Service database to collect data on patients with mild cognitive impairment enrolled between 2013 and 2016 and followed up until 2021.

Oxamate suppresses whole-body energy metabolism at rest and during exercise in mice by inhibiting fat oxidation and altering lactate dynamics.

Purpose: Oxamate is a well-known inhibitor of glycolysis. However, its broad inhibitory effects on whole-body energy metabolism in vivo have not been identified. Therefore, we aimed to investigate its effects on wholebody energy metabolism in mice.

Effects of β-mannanase on intestinal health and growth performance of nursery to growing pigs fed diets with DDGS.

A total of 84 pigs (17.6 ± 2.8 kg initial body weight at 6 wk of age) were used in a 40-d trial to evaluate the effects of dietary supplemental β-mannanase (400 U/kg feed, CTCBIO Inc.

Activation of telomerase via madecassic acid enhances the developmental competence of the SCNT-derived bovine embryos.

Somatic cell nuclear transfer (SCNT) is important in assisted reproductive technologies. However, its reprogramming efficiency remains low. A considerable drawback of SCNT-cloned embryos is the reduction in telomerase activity, which is crucial for DNA stability and genetic and epigenetic reprogramming.

Functional Requirement of Niacinamide for Blood Profiles, Antioxidant Status, and Intestinal Health in Finishing Pigs Fed a Low-Protein Diet.

This study investigated the effects of dietary niacinamide supplementation on blood parameters, antioxidant status, and intestinal health in finishing pigs fed low-protein diets. Sixty-four pigs (Duroc × Landrace × Yorkshire; 80.4 ± 0.

Effects of enzyme-treated soy oligopeptide on intestinal health, feed preference, and growth performance in nursery pigs.

Objective: The objective was to evaluate the effects of replacing soybean meal (SBM) with enzyme-treated soy oligopeptide (ESO) in nursery pig diets on intestinal health, growth performance, and feed preference.

Methods: In Exp. 1, 128 pigs (average 5.

Does a specific age group impact sperm cryobanking efficiency among adolescent and young adult cancer patients?

Objective: Fertility preservation is vital for adolescent and young adult (AYA) cancer patients. Sperm cryobanking is a key option, but age-related factors influencing its efficiency remain unclear. This study evaluated the impact of age on cryobanking attempts, success rates, and disposition outcomes among AYA patients with cancer aged 11-25 years.

Low Thyrotropin Levels Are Associated With an Increased Risk of Atherosclerotic Cardiovascular Disease in Euthyroid Individuals: The Korea National Health and Nutrition Examination Survey 2013-2015.

Objective: This study aimed to determine whether thyrotropin (thyroid-stimulating hormone [TSH]) levels within the physiologic range influence the risk of atherosclerotic cardiovascular disease (ASCVD) in euthyroid individuals.

Methods: A cross-sectional survey was conducted using data from the Korea National Health and Nutrition Examination Survey (2013-2015). After excluding participants with abnormal thyroid function or a history of thyroid disease or ASCVD, 2,995 euthyroid individuals aged 40-79 years were included.

Effects of 12-week combined whole-body electric muscle stimulation and lower-extremity strength training on body composition, blood lipid levels, and isokinetic muscle function of patients with obesity and knee pain.

Purpose: We examined the effects of a 12-week combined treatment intervention consisting of whole-body electric muscle stimulation (WB-EMS) and lower-extremity strength exercise on body composition, blood lipid levels, knee pain, and functional ability of patients with obesity and knee pain.

Methods: Fourteen patients with obesity and knee pain were randomly assigned to a control group (CON; n = 7) that performed lower-extremity strength exercises and an experimental group (EXP; n = 7) that performed lower-extremity strength exercises combined with WB-EMS. All participants performed the exercise program three days a week for 12 weeks.

Effect of 10 weeks combined passive stretching and lower extremity strength exercise intervention on muscle stiffness, pain, and physical function in middle-aged women with back pain.

Purpose: This study compared the effects of 10 weeks of combined exercises (passive stretching and lower extremity strength) and lumbar stabilization exercises on muscle stiffness, pain, and physical function in middle-aged women with back pain.

Methods: Thirty-five middle-aged women experiencing continuous back pain for at least 6 months who visited the hospital for treatment and diagnosis were recruited. The participants were randomly divided into two groups: a lumbar stabilization exercise group (LSEG, n = 18) and a combined exercise group (CEG, n = 17), which included passive stretching and lower extremity strength exercises.

Implications of heart rate variability measured using wearable electrocardiogram devices in diagnosing Parkinson's disease and its association with neuroimaging biomarkers: a case-control study.

Introduction: Heart rate variability (HRV) reflects cardiac autonomic regulation, and reduced HRV is associated with Parkinson's disease (PD). However, studies regarding the implications of HRV measures for the clinical manifestations of PD have shown inconclusive results. We examined the relationship between HRV measures obtained via long-term monitoring using a wearable electrocardiogram (ECG) device and the diagnosis and clinical characteristics of PD.

Exercise-Induced Hippocampal Neurogenesis Is Attenuated by Inhibition of Monocarboxylate Transporter 2.

Several studies have suggested that lactate mediates exercise-induced hippocampal neurogenesis. To investigate this, we used a monocarboxylate transporter (MCT) inhibitor, alpha-cyano-4-hydroxycinnamic acid (4CIN), to attenuate the signaling effect of endogenous lactate in the hippocampus. Ten-week-old ICR mice were intraperitoneally injected with 100 mg/kg 4CIN before beginning moderate-intensity treadmill exercise 5 days a week for 8 weeks.

Protective effects and mechanisms of cynaroside on renal fibrosis in mice with unilateral ureteral obstruction.

Renal fibrosis is a key factor in the progression of chronic kidney disease (CKD), and current treatments remain inadequate. In this study, we investigated the therapeutic effects of cynaroside (Cyn), a natural flavonoid, in a mouse model of renal fibrosis induced by unilateral ureteral obstruction. Cyn treatment significantly ameliorated tubular injury and interstitial fibrosis while improving renal function.

Effects of a 6-Week Concurrent Training Program Combining Resistance and Various Modalities of Aerobic Exercise in Obese Women with Prehypertension: A Randomized Controlled Trial.

: Our study aimed to verify the effects of 6 weeks of concurrent training composed of resistance training (RT) and different modalities of aerobic exercise (moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT)) on body composition, blood pressure, vascular function, autonomic nervous system (ANS) function, blood lipid levels, cardiometabolic index (CMI), and health-related fitness in obese middle-aged women with prehypertension. : We selected 26 middle-aged women with obesity and prehypertension and divided them equally into the RT + MICT (n = 13) and RT + HIIT (n = 13) groups. The concurrent training program consisted of warm-up, RT, aerobic exercise (MICT or HIIT), and cool-down, and was performed for 6 weeks, three times a week, 85-100 min per session.

Efficacy of β-Glucan From Microalgae on the Intestinal Health and Growth of Nursery Pigs.

This study aimed to investigate the efficacy of β-glucan from microalgae (Algamune, Algal Scientific, Plymouth, MI, USA) on the intestinal health and growth of nursery pigs. One hundred sixty nursery pigs (6.0 ± 1.

Impacts of non-starch polysaccharide sources with enzymes influencing intestinal mucosa-associated microbiota and mucosal immunity of nursery pigs on growth and carcass traits at market weight.

Background: This study investigated the effects of different non-starch polysaccharide (NSP) sources with NSP degrading enzymes (NSPases) and the influence on the mucosa-associated microbiota and intestinal immunity of nursery pigs, on growth performance and carcass traits at market weight.

Methods: One hundred and sixty newly weaned pigs at 7.0 ± 0.

Effects of increasing levels of benzoic acid fed to pigs on nitrogen utilization and metabolism affecting growth performance, ammonia emissions, and carcass characteristics.

The objectives of this study were to investigate the effects of increasing levels of benzoic acid (BA) on nitrogen utilization and metabolism affecting growth performance, ammonia emissions, and carcass characteristics, and to determine the optimal levels of BA for the growth performance and carcass characteristics when fed to pigs from weaning to market. A total of 480 pigs (6.0 ± 1.

Association between L-α glycerylphosphorylcholine use and delayed dementia conversion: A nationwide longitudinal study in South Korea.

Background: Alzheimer's disease and vascular dementia are two of the most common causes of dementia. While early diagnosis and intervention are crucial, available treatments and research concerning the mild cognitive impairment stage remain limited. This study aimed to evaluate the real-world effectiveness and safety of L-α glycerylphosphorylcholine in this context.

Antibiotics and Opportunities of Their Alternatives in Pig Production: Mechanisms Through Modulating Intestinal Microbiota on Intestinal Health and Growth.

Antibiotics at subtherapeutic levels have been used in pig diets as antimicrobial growth promoters. However, concerns about antibiotic resistance have increased the demand for alternatives to these antimicrobial growth promoters. This review paper explores the mechanisms through which antimicrobial growth promoters and their alternatives exert their antimicrobial effects.

Persistent influence of past obesity on current adiponectin levels and mortality in patients with type 2 diabetes.

Background/aims: Adiponectin, a hormone primarily produced by adipocytes, typically shows an inverse relationship with body mass index (BMI). However, some studies have reported a positive correlation between the two. Thus, this study aimed to examine the relationship between adiponectin level and BMI in diabetic patients, focusing on the impact of past obesity on current adiponectin levels.

Longitudinal changes of automated volumetric breast density with postmenopausal hormone therapy.

Objective: To evaluate how volumetric percent density (VPD) changes longitudinally with postmenopausal hormone therapy (HT).

Study Design: Medical records of 297 women who visited the outpatient clinic in a tertiary medical center between 2011 and 2019 were retrospectively reviewed. Study participants were postmenopausal hormone never-users (n = 103), estrogen therapy (ET) users (n = 95), and estrogen plus progestogen (EPT) users (n = 99).