Variability in trends of opioid-related hospital utilization among U.S. Adults, 2016-2021 check.

Background: Understanding trends in opioid-related hospital utilization is crucial for informing public health policies; however, existing research is often limited in scope and methodology. This study provides national estimates from 2016 to 2021, emphasizing the variability in trends across different opioid categories and subpopulations.

Methods: This study employed a repeated cross-sectional analysis using data from the National Inpatient Sample (NIS) and Nationwide Emergency Department Sample (NEDS).

Targeting RelA/NLRP3/CCL3 axis mitigates microglia inflammatory response and promotes recovery after spinal cord injury.

Spinal cord injury (SCI) leads to loss of motor and sensory function below the lesion site, presenting a lifelong burden of disability. During the acute phase of SCI, microglia develop an inflammatory phenotype, characterized by the NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling activation, exacerbating tissue damage and impeding trauma recovery. However, the molecular mechanisms underlying this process remain unclear.

Rates, Causes, and Predictive Factors of Hospital Readmissions After Spine Surgery for Lumbar Spinal Stenosis: A Nationwide Retrospective Cohort Study.

Objective: This study aimed to determine the rates, causes, and predictive factors of readmissions at different periods following spine surgery, up to 180 days.

Methods: This study utilized data from the 2018 to 2019 Nationwide Readmissions Database and included four postoperative periods: 0 to 7 days, 8 to 30 days, 31 to 90 days, and 91 to 180 days. The causes of readmissions and potential predictive factors were systematically identified.

Protocol for the Chinese Real-World Evidence for Acute Spinal Cord Injury (ChiRES) study: a prospective, observational, multicentre cohort study of acute spinal cord injury.

Introduction: Spinal cord injury (SCI) is a catastrophic event with devastating physical, social and occupational consequences for patients and their families. The number of patients with acute SCI in China continues to grow rapidly, but there have been no large prospective cohort studies of patients with acute SCI. This proposed study aims to establish a multicentre, extensive sample cohort of clinical data and biological samples of patients in China, which would aid the systematisation and standardisation of clinical research and treatment of acute SCI, thus reducing the heavy burden of acute SCI on patients and society.

Traumatic spinal injury-related hospitalizations in the United States, 2016-2019: a retrospective study.

Background: Traumatic spinal injury (TSI) is associated with significant fatality and social burden; however, the epidemiology and treatment of patients with TSI in the US remain unclear.

Materials And Methods: An adult population was selected from the National Inpatient Sample database from 2016 to 2019. TSI incidence was calculated and TSI-related hospitalizations were divided into operative and nonoperative groups according to the treatments received.

A critical appraisal of clinical practice guidelines on surgical treatments for spinal cord injury.

Background Context: Spinal cord injury (SCI) is a global health problem with a heavy economic burden. Surgery is considered as the cornerstone of SCI treatment. Although various organizations have formulated different guidelines on surgical treatment for SCI, the methodological quality of these guidelines has still not been critically appraised.

A critical appraisal of clinical practice guidelines for management of four common complications after spinal cord injury.

Background Context: Complications such as pressure sores, pulmonary infection, urinary tract infection (UTI), and venous thromboembolism (VTE) are common after spinal cord injury (SCI). These have serious consequences for patients' physical, social, and vocational well-being. Several authoritative organizations have developed guidelines for managing these complications after SCI.

A critical appraisal of clinical practice guidelines on pharmacological treatments for spinal cord injury.

Background Context: Spinal cord injury brings devastating consequences and huge economic burden. Different authoritative organizations have developed different guidelines for pharmacological treatments of spinal cord injury, but there is a lack of a critical appraisal of them.

Purpose: To systematically review and appraise guidelines regarding their recommendations for pharmacological treatments for spinal cord injury.

Clinical features and burden of osteoporotic fractures among the elderly in the USA from 2016 to 2018.

Unlabelled: This study provides a national estimate of the incidence of hospitalizations and assesses the clinical features and outcomes during inpatient admission due to osteoporotic fractures diagnosed by ICD-10-CM/PCS among the elderly in the USA, using the US Nationwide Inpatient Sample, 2016-2018.

Purpose: To provide a national estimate of the incidence of hospitalizations and assess the clinical features and outcomes during inpatient admission due to osteoporotic fractures (OFs) among the elderly in the USA.

Methods: The study included all inpatients aged 65 years and older who participated in the US Nationwide Inpatient Sample (NIS).

m A demethylase ALKBH5 drives denervation-induced muscle atrophy by targeting HDAC4 to activate FoxO3 signalling.

Background: Skeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment of primary neuropathies, it is a clinical condition that should be investigated. FoxO3 activation is an indispensable mechanism in denervation-induced muscle atrophy; however, upstream factors that control FoxO3 expression and activity have not been fully elucidated.

Magnesium supplementation enhances mTOR signalling to facilitate myogenic differentiation and improve aged muscle performance.

Magnesium (Mg), as an essential mineral, supports and sustains the health and activity of the organs of the human body. Despite some clinical evidence on the association of Mg deficiency with muscle regeneration dysfunction and sarcopenia in older-aged individuals, there is no consensus on the action mode and molecular mechanism by which Mg influences aged muscle size and function. Here, we identified the appropriate Mg environment that promotes the myogenic differentiation and myotube hypertrophy in both C2C12 myoblast and primary aged muscle stem cell (MuSC).