Publications by authors named "Zhongze Yuan"
Spinal cord injury (SCI) leads to loss of motor and sensory function below the lesion site, presenting a lifelong burden of disability. During the acute phase of SCI, microglia develop an inflammatory phenotype, characterized by the NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling activation, exacerbating tissue damage and impeding trauma recovery. However, the molecular mechanisms underlying this process remain unclear.
View Article and Find Full Text PDFNicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury.
Stem Cell Rev Rep
October 2024
Article Synopsis
- Activation of endogenous neural stem cells (NSCs) can promote healing after spinal cord injuries, but methods to regulate these cells are limited.
- This study found that nicotinamide riboside enhances the growth of NSCs and helps them differentiate into neurons, leading to improved lower limb motor function after injury.
- The mechanism behind this involves the activation of the Wnt signaling pathway through the LGR5 gene, as blocking this pathway hinders the effects of nicotinamide riboside on NSC proliferation.
New strategy to treat spinal cord injury: Nafamostat mesilate suppressed NLRP3-mediated pyroptosis during acute phase.
Int Immunopharmacol
June 2024
Spinal cord injury (SCI) is a devastating condition for which effective clinical treatment is currently lacking. During the acute phase of SCI, myriad pathological changes give rise to subsequent secondary injury. The results of our previous studies indicated that treating rats post-SCI with nafamostat mesilate (NM) protected the blood-spinal cord barrier (BSCB) and exerted an antiapoptotic effect.
View Article and Find Full Text PDFSpinal cord injury (SCI) causes motor, sensory and automatic impairment due to rarely axon regeneration. Developing effective treatment for SCI in the clinic is extremely challenging because of the restrictive axonal regenerative ability and disconnection of neural elements after injury, as well as the limited systemic drug delivery efficiency caused by blood spinal cord barrier. To develop an effective non-invasive treatment strategy for SCI in clinic, we generated an autologous plasma exosome (AP-EXO) based biological scaffold where AP-EXO was loaded with neuron targeting peptide (RVG) and growth-facilitating peptides (ILP and ISP).
View Article and Find Full Text PDFIncreasing evidence has revealed the promise of mRNA-type cancer vaccines as a new direction for cancer immune treatment in several solid tumors, however, its application in papillary renal cell carcinoma (PRCC) remains unclear. The purpose of this study was to identify potential tumor antigens and robust immune subtypes for the development and appropriate use of anti-PRCC mRNA vaccines, respectively. Raw sequencing data and clinical information of PRCC patients were downloaded from The Cancer Genome Atlas (TCGA) database.
View Article and Find Full Text PDFArticle Synopsis
- Using minimally invasive methods for spinal cord injury (SCI) modeling can enhance experiment consistency and reduce behavioral differences among animals.
- The technique requires a clear surgical anatomy and simple laboratory equipment to minimize harm to the experimental subjects.
- The study investigates a new SCI coaxial platform to safely access and impact the T9 spinal cord in mice, presenting histological findings as a reference.