Public health impact of the adjuvanted RSVPreF3 vaccine in adults aged 60 years and older: results from a modeling study in six Latin American countries.

Background: Respiratory syncytial virus (RSV) can cause acute respiratory infection (ARI) and severe symptoms in older adults. The adjuvanted RSV prefusion F protein vaccine (adjuvanted RSVPreF3) offers protection to adults against RSV ARI and RSV lower respiratory tract disease (LRTD). We modeled the RSV burden and the public health impact of RSV vaccination in adults ≥60 years in six Latin American countries.

Public health impact of adjuvanted RSVPreF3 vaccine in older adults: a modeling study in nine countries in Middle East and North Africa.

Background: The adjuvanted RSV prefusion F protein vaccine (adjuvanted RSVPreF3) can protect older adults against respiratory syncytial virus (RSV) infection and RSV-related lower respiratory tract disease (LRTD). We modeled the burden of RSV and the potential public health impact of RSV vaccination in adults ≥60 years in nine countries of the Middle East and North Africa (MENA) region.

Research Design And Methods: A Markov model was adapted to the settings of Bahrain, Egypt, Saudi Arabia, Kuwait, Morocco, Oman, Qatar, Turkey, and the United Arab Emirates.

Potential public health impact of the adjuvanted RSVPreF3 vaccine in adults aged 60 years and older: results from a modeling study in India and Southeast Asia.

Background: Respiratory syncytial virus (RSV) can cause acute respiratory infection (ARI) and severe symptoms in adults ≥60 years. The adjuvanted RSV prefusion F protein vaccine (adjuvanted RSVPreF3) offers protection to adults against RSV ARI and RSV lower respiratory tract disease (LRTD). We modeled the burden of RSV among adults ≥60 years in India and Southeast Asia, and the potential impact of RSV vaccination.

Economic Evaluation of PHID-CV versus PCV10-SII Compared with no Vaccination in the Philippines.

Introduction: Streptococcus pneumoniae can cause serious invasive pneumococcal disease (IPD), such as pneumonia, meningitis and bactaeremia. Two pneumococcal polysaccharide conjugate vaccines (PCV), the 13-valent PCV13 and 10-valent PHiD-CV, are included in the Philippines' National Formulary and implemented in the national immunisation programme. Recently, a new 10-valent PCV (PCV10-SII) has received World Health Organization prequalification status.

Corrigendum: An image dataset for analyzing tea picking behavior in tea plantations.

[This corrects the article DOI: 10.3389/fpls.2024.

An image dataset for analyzing tea picking behavior in tea plantations.

Tea is an important economic product in China, and tea picking is a key agricultural activity. As the practice of tea picking in China gradually shifts towards intelligent and mechanized methods, artificial intelligence recognition technology has become a crucial tool, showing great potential in recognizing large-scale tea picking operations and various picking behaviors. Constructing a comprehensive database is essential for these advancements.

Modified -stabilized Pickering emulsions loaded with the essential oil of Schott: preparation, characterization and evaluation.

Essential oil of Schott (ATEO) have significant biological activity, but their physical and chemical properties are unstable and susceptible to interference by external factors, resulting in oxidation, decomposition, and isomerization of essential oils (EOs), ultimately diminishing the quality of EOs and escalating clinical risks. In this research, based on the concept of " combination of medicine and adjuvant, " the unsuitable stabilizer in Lingzhu powder prescription was modified with a SiO surface to become a stabilizer suitable for Pickering emulsion. The modified was synthesized, with a focus on exploring the surface modification of to facilitate its role as a stabilizer in Pickering emulsion.

Analysis of Prognostic Factors in Non-Traumatic and Non-Diabetic Retinopathy Patients Undergoing Vitrectomy.

Aim: Vitrectomy is one of the crucial therapeutic interventions for non-traumatic and non-diabetic retinal diseases. However, the prognosis of patients undergoing this procedure and the factors affecting prognosis remain to be clarified. The aim of this study was to analyze the prognostic factors of non-traumatic and non-diabetic retinopathy complicated by vitreous hemorrhage.

Modelling the Public Health Burden of Herpes Zoster and the Impact of Adjuvanted Recombinant Zoster Vaccine in Five Selected Countries in Southeast Asia.

Introduction: Herpes zoster (HZ) can cause substantial patient morbidity and lead to large healthcare costs. However, the disease burden of HZ in Southeast Asia may be underestimated. This study aimed to estimate the public health burden of HZ and the impact of vaccinating adults aged ≥ 50 years old in five Southeast Asian countries (Indonesia, Malaysia, Philippines, Thailand, and Vietnam), with adjuvanted recombinant zoster vaccine (RZV) compared with no vaccination.

A Latent Transition Analysis of Aggression Victimization Patterns During the Transition from Primary to Middle School.

School transitions provide contexts for adolescents to reconstruct peer relationships and re-establish social positions. Scarce research has captured the transition of aggressor and victim roles during this period and examined associated factors. To investigate the stability and shifts of aggressor and victim roles following the transition to middle school, this study conducted latent transition analysis with 1261 Chinese adolescents (32.

Bifidobacteria in disease: from head to toe.

Bifidobacteria as a strictly anaerobic gram-positive bacteria, is widely distributed in the intestine, vagina and oral cavity, and is one of the first gut flora to colonize the early stages of life. Intestinal flora is closely related to health, and dysbiosis of intestinal flora, especially Bifidobacteria, has been found in a variety of diseases. Numerous studies have shown that in addition to maintaining intestinal homeostasis, Bifidobacteria may be involved in diseases covering all parts of the body, including the nervous system, respiratory system, genitourinary system and so on.

How large could the public health impact of introducing recombinant zoster vaccination for people aged ≥50 years in five Latin American countries be?

This study aimed to: (1) estimate the disease burden of herpes zoster (HZ) and (2) assess the potential public health impact of introducing adjuvanted recombinant zoster vaccine (RZV) compared with no vaccination in adults aged ≥50 years in Argentina, Brazil, Mexico, Chile, and Colombia using the ZOster ecoNomic Analysis (ZONA) static multicohort Markov model. The model followed individuals aged ≥50 years from administration of RZV over their remaining lifetime. Inputs were based, most often, on local data.

[Retracted] Astragaloside IV inhibits oxidized low‑density lipoprotein‑induced endothelial damage via upregulation of miR‑140‑3p.

Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that the β‑actin control western blotting data featured in Fig. 3E were strikingly similar to data appearing in different form in another article by different authors. Upon asking the authors to explain this phenomenon, they were unable to provide the raw data for this experiment.

Co-administration of tacrolimus and low molecular weight heparin in patients with a history of implantation failure and elevated peripheral blood natural killer cell proportion.

Aim: To investigate the therapeutic effect of co-administration of tacrolimus (TAC) and low-molecular-weight heparin (LMWH) or LMWH only on pregnancy outcomes in the female with a history of implantation failure and elevated peripheral blood natural killer (pNK) cell proportion in frozen-thawed embryo transfer cycles.

Methods: To evaluate the pregnancy parameters for 249 patients with ≥2 implantation failures and pNK cell proportion ≥12% by analyzing a retrospective observational cohort study. Sixty patients had received the co-administration TAC and LMWH (TAC & LMWH group), 85 others had only taken LMWH (LWMH group), and the rest did not take any particular drugs (control group).

iStent and cataract surgery for mild-to-moderate primary open angle glaucoma in Japan: a cost-utility analysis.

Aim: To evaluate the cost-utility of iStent with cataract surgery cataract surgery alone in patients with mild-to-moderate primary open angle glaucoma (POAG) in the Japanese setting from a public payer's perspective.

Methods: A Markov model was adapted to estimate the cost-utility of iStent plus cataract surgery cataract surgery alone in one eye in patients with mild-to-moderate POAG over lifetime horizon from the perspective of Japanese public payer. Japanese sources were used for patients' characteristics, clinical data, utility, and costs whenever available.

Uterine fibroids increase the risk of preterm birth and other adverse birth events: a systematic review and meta-analysis.

Background: Uterine fibroids may cause preterm birth. This meta-analysis evaluates the effect of uterine fibroids on the risk of preterm birth and other obstetric outcomes.

Methods: Using the literature review method, the databases PubMed, Medline, Embase and Central were retrieved to obtain relevant research literature.

Challenges in the market access of regenerative medicines, and implications for manufacturers and decision-makers: a systematic review.

Regenerative medicines (RMs) are expected to transform the treatment paradigm of rare, life-threatening diseases, while substantial challenges impede its market access. This study aimed to present these challenges. Publications identified in the Medline and Embase databases until December 2020 were included.

Partnership agreements for regenerative medicines: a database analysis and implications for future innovation.

Partnerships have been leveraged to advance the regenerative medicines (RMs) development. This study analyzed the evolution of partnership landscape for regenerative medicines (RMs). Partnership agreements publicly announced from January 2014 - June 2020 were described.

The impact of COVID-19 on the cell and gene therapies industry: Disruptions, opportunities, and future prospects.

Coronavirus 2019 (COVID-19) has caused significant disruption to the cell and gene therapy (CGT) industry, which has historically faced substantial complexities in supply of materials, and manufacturing and logistics processes. As decision-makers shifted their priorities to COVID-19-related issues, the challenges in market authorisation, and price and reimbursement of CGTs were amplified. Nevertheless, it is encouraging to see that some CGT developers are adapting their efforts toward the development of promising COVID-19-related therapeutics and vaccines.

Allocating treatment resources for hepatitis C in the UK: a constrained optimization modelling approach.

Although the treatment of chronic hepatitis C (CHC) has significantly evolved with the introduction of direct-acting antivirals, the treatment uptake rates have been low especially among marginalized groups in the UK, such as people who inject drug (PWID) and men who have sex with men (MSM). Cutting health inequality is a major focus of healthcare agencies. This study aims to identify the optimal allocation of treatment budget for chronic hepatitis CHC among populations and treatments in the UK so that liver-related mortality in patients with CHC is minimized, given the constraint of treatment budget and equity issue.

Evaluation of the Therapeutic Effect of Traditional Chinese Medicine on Osteoarthritis: A Systematic Review and Meta-Analysis.

Background: Osteoarthritis (OA) is a common degenerative disease of bone and joint characterized by the damage of articular cartilage and hypertonia, which often occurs in the middle-aged and elderly. Traditional Chinese medicine (TCM) therapy, including acupuncture (ACU), oral administration, and external use of traditional Chinese medicines (TCMs), can significantly improve the therapeutic effect on OA and reduce the occurrence of side effects. We provide a latest meta-analysis on the treatment of OA with TCM.