Ternary Co-Assembly Synthesis of Mesoporous Transition Metal Dichalcogenides/Oxides Heterostructures for Synergistically Enhanced Room-Temperature Chemiresistive Sensors.

Constructing transition metal dichalcogenides/oxides (TMDs/TMOs) heterostructures is an effective strategy to enhance their functional properties through band coupling and carrier migration. Furthermore, introducing a mesoporous architecture into TMDs/TMOs can significantly improve their porosity and specific surface area, thereby boosting their performance in chemical sensing, energy storage/conversion, and catalysis. However, it remains a significant challenge to realize a direct and facile synthesis of mesoporous TMDs/TMOs (mTMDs/TMOs) heterostructures with tunable compositions and abundant heterogeneous interfaces.

CHAC1 in urological tumors: contextual dualism and therapeutic implications.

CHAC1, a glutathione-degrading enzyme, governs context-dependent pathophysiological processes in urological malignancies through modulation of endoplasmic reticulum stress and ferroptotic pathways. In clear cell renal cell carcinoma (ccRCC), CHAC1 exhibits stage-specific functional duality: downregulation in early-stage tumors correlates with adverse prognosis (suggesting tumor-suppressive activity), whereas elevated expression in advanced ccRCC (G3-G4/Stage III-IV) associates with increased mortality (indicating adaptive pro-survival adaptation). For prostate cancer, CHAC1 potentiates docetaxel cytotoxicity via coordinated induction of endoplasmic reticulum stress and ferroptosis, yet its suppression by cancer-associated fibroblast-derived exosomal miR-432-5p establishes therapy-reinforced chemoresistance.

Machine Learning Model Integrating Computed Tomography Image-Derived Radiomics and Circulating miRNAs to Predict Residual Teratoma in Metastatic Nonseminoma Testicular Cancer.

Purpose: Chemotherapy is the primary treatment for metastatic nonseminomatous germ cell tumors (mNSGCTs), but patients often encounter postchemotherapy residual disease. Accurate noninvasive methods are needed to predict the histology of these masses, guiding treatment and reserving surgery for those with teratoma. This study aims to enhance predictive accuracy by integrating computed tomography (CT) radiomics features with miRNAs (miR371-375) to distinguish between teratoma and nonteratoma histology in postchemotherapy residual masses.

Multi-channel polarization conversion THz beam splitter based on phase gradient metasurface.

In terahertz (THz) optical systems, beam splitters are essential components. However, they still have challenges in multi-channel manipulation of THz waves. Multi-channel beam splitters are devices that simultaneously split and independently control beams through multiple channels.

Rotational Doppler effect of superimposed elliptical optical vortices for oblique rotational axis detection.

The rotational Doppler effect (RDE) of structured light carrying orbital angular momentum (OAM) has attracted widespread interest in optical sensors and OAM spectrum detection. However, the motion parameters of spinning objects are the main focus of the RDE-based research, and other equally significant attitude properties have rarely been considered. In the experiments, we noticed an intriguing phenomenon: the rotational Doppler spectral distribution is affected by both the ellipticity of the elliptical optical vortex (EOV) and the tilt angle between the rotational axis and the optical axis.

Intelligent text analysis for effective evaluation of english Language teaching based on deep learning.

With the growing demand for English language teaching, the efficient and accurate evaluation of students' writing ability has become a key focus in English education. This study introduces a Hybrid Feature-based Cross-Prompt Automated Essay Scoring (HFC-AES) model that leverages deep learning for intelligent text analysis. Building on traditional deep neural networks (DNNs), the model incorporates text structure features and attention mechanisms, while adversarial training is employed to optimize feature extraction and enhance cross-prompt adaptability.

Effects of Defocus Distance and Weld Spacing on Microstructure and Properties of Femtosecond Laser Welded Quartz Glass-TC4 Alloy Joints with Residual Stress Analysis.

This study develops an optimized femtosecond laser welding process for joining quartz glass and TC4 titanium alloy (Ti-6Al-4V) under non-optical contact conditions, specifically addressing the manufacturing needs of specialized photoelectric effect research containers. The joint primarily consists of parallel laser-welded zones (WZ) interspersed with base material. The defocus distance of the femtosecond laser predominantly influences the depth and phase composition of the WZ, while the weld spacing influences the crack distribution in the joint region.

Clinical Implications of Noninvasive Prenatal Testing Failures Due to Low Fetal Fraction: Associations With Adverse Maternal and Fetal Outcomes.

Objective: To identify risk factors associated with noninvasive prenatal testing (NIPT) failures due to a low fetal fraction (LFF, < 4%) and to evaluate appropriate management strategies.

Methods: This was a single retrospective cohort study conducted on consecutive NIPT procedures performed at a national prenatal diagnosis center between April 2016 and June 2022.

Results: Among the 41,693 NIPT procedures conducted at Peking Union Medical College Hospital, 524 cases (1.

ALKBH5-mediated NPC2 mRNA mA demethylation promotes resistance to oxaliplatin in colorectal cancer.

Colorectal cancer (CRC) is the third most common cancer globally and a leading cause of cancer-related death. Oxaliplatin, a key platinum-based chemotherapy, significantly improves outcomes in CRC patients. Nevertheless, oxaliplatin resistance often emerges, leading to worse prognosis.

Nodal modulator (NOMO) is a force-bearing transmembrane protein required for muscle differentiation.

The ER relies on membrane-shaping proteins to maintain a continuous network of sheets and tubules that host distinct biological processes. How this intricate structure of the ER membrane system is maintained under conditions of mechanical strain is incompletely understood. NOMO is an ER-resident transmembrane protein that contributes to ER morphology and is highly expressed in striated muscle.

Genetic diversity of HIV in Yunnan, China: the role of second-generation recombination involving circulating and unique recombinant forms.

Background: The genetic diversity of HIV is significantly influenced by second-generation recombination events involving circulating recombinant forms (CRFs) and unique recombinant forms (URFs), which are crucial for the virus's evolution and dissemination. The China-Myanmar border region is recognized as a focal point for inter-subtype recombination of HIV, with recombinant strains predominating in this area.

Methods: Near full-length HIV genomes were amplified from plasma samples of eight Burmese individuals newly diagnosed with HIV in Baoshan, China, from 2006 to 2020.

Survival After Partial Cystectomy Versus Radical Cystectomy for Non-Urothelial Carcinoma of the Bladder: A Population-Based Study.

Background: The aim of this study was to compare cancer-specific survival (CSS) and overall survival (OS) after partial cystectomy (PC) versus radical cystectomy (RC) in patients with stage T2N0M0 non-urothelial carcinoma of the bladder (NUCB).

Methods: Data on patients with stage T2N0M0 NUCB treated with PC or RC were retrospectively retrieved from the Surveillance, Epidemiology, and End Results (SEER) database from 2007 to 2015. Propensity score matching (PSM) was used to create matched cohorts, which were used to calculate OS and CSS.

Elucidating programmed cell death in diabetic retinal microangionopathy and neurodegeneration: unraveling molecular mechanisms and therapeutic actions of natural products.

Diabetic retinopathy (DR) is a common diabetes condition that contributes significantly to vision impairment and blindness in working-age people. The classical theory contends that DR is solely a retinal microvascular disorder. Nevertheless, a growing body of research has demonstrated that the pathological variations of DR consist of retinal microangiopathy and retinal neurodegeneration triggered by hyperglycemia.

Achieving 500-GHz communication over 1.2 km using an astronomical telescope with a quantum-limited superconducting receiver.

500 GHz video transmission over 1.2 km is achieved using an astronomical telescope equipped with a quantum-limited superconducting SIS receiver.

The role and mechanism of lung microbiota in coal mine dust-induced NLRP3 inflammasome upregulate and lung injury.

The exact molecular mechanisms of coal workers' pneumoconiosis (CWP) are still unknown. The purpose of this study is to investigate how the lung microbiota may contribute to the development of CWP. The rats were divided into five groups, including the control group, CWP group, silicosis group, CWP + antibiotic group, and CWP + MCC950 group.

Stable Tensile-Strained Pt Single Atomic Layer Catalysts on α-MoC for Efficient Alkaline Hydrogen Evolution.

Developing Pt-based core-shell catalysts with ultralow Pt loading, superior performance, and extended durability holds tremendous potential for advancing electrochemical energy storage and conversion technologies. However, current synthetic limitations persist in achieving atomically efficient Pt monolayer deposition on nonprecious metal substrates, hindering the maximization of Pt atomic utilization for cost-effective catalyst design. Here, we demonstrate a galvanic replacement strategy to synthesize tensile-strained platinum single-atom-layer (Pt SAL) on α-MoC substrates.

Metabolic regulation of enhanced biodegradation of petroleum hydrocarbons through quorum sensing by extracellular metabolites of euglena.

The quorum sensing (QS) system can regulate and enhance the degradation of petroleum pollutants. Enhancing the indigenous microbial QS system by adding environmentally friendly biostimulants is currently a preferred strategy for achieving high stability, sustainability, and cost-effective biodegradation of petroleum contaminants. However, the intrinsic mechanisms by which biostimulants induce QS-mediated regulation of petroleum hydrocarbon degradation remain unclear.

A nomogram model for prognosis of acute ischemic stroke treated with recombinant tissue-type plasminogen activator.

Objective: The primary objective of this study was to systematically assess the prognostic utility of neutrophil-derived inflammatory indices-specifically the neutrophil-to-lymphocyte ratio (NLR) and systemic inflammation response index (SIRI)-and subsequently develop a predictive model for thrombolysis outcomes through the integration of these hematological biomarkers with clinical parameters, including acute-phase neurological severity (as quantified by baseline National Institutes of Health Stroke Scale [NIHSS] scores) and therapeutic timeliness (door-to-needle time, DNT) in acute ischemic stroke patients receiving recombinant tissue plasminogen activator (rt-PA) therapy.

Methods: This retrospective cohort study analyzed consecutive patients with AIS who received intravenous thrombolysis with rt-PA at the First People's Hospital of Chuzhou in Anhui Province, China, between January 2021 and July 2023. Peripheral blood samples were collected within 24 h of admission to evaluate the NLR and SIRI.

Chinese population may require further venetoclax dose reduction beyond guidelines when combined with voriconazole: real-world evidence from China.

Objective: Azole antifungals inhibit the enzyme cytochrome P450 3A4 (CYP 3A4), increasing venetoclax (VEN) levels and the risk of serious adverse reactions. Dose adjustments for VEN with voriconazole (VOR) vary in studies. The drug-drug interactions (DDI), safety and economic implications of VEN with VOR in the Chinese population, who may have unique drug exposures, are unclear.

Mechanisms of force transmission on cytokinesis Formin Cdc12 in fission yeast revealed by coiled-coil force sensors.

Cytokinesis is a fundamental process in cell division, where an actomyosin contractile ring plays a central role in completing the cell division. Although some experimental and computational efforts have evaluated ring tension and the molecular organization of rings, the mechanisms of force transmission at the molecular level remain unclear. Here, we used our novel coiled-coil force sensors to measure the force distribution along the formin Cdc12, a key cytokinesis protein in fission yeast.

Galactose-modified erythrocyte membrane fusion liposomes enable the targeted delivery of drug nanoparticles to the liver.

The safe and efficient delivery of chemicals and biologics remains crucial for liver disease therapy. In this study, we developed a targeted drug delivery system utilizing a galactose-modified erythrocyte membrane coating technique and drug liposome nanoparticles, which were further optimized using orthogonal experiments and response surface analysis. The specificity, precision, accuracy, and stability exhibited satisfactory performance in bioanalytical analysis.

Genome-wide characterization of sphingolipid metabolism pathway under abiotic stresses reveals BnaCERK playing a positive role in drought resistance in Brassica napus.

Sphingolipids play crucial roles in plant response to environmental change. However, the molecular mechanism underlying plant adaptation to abiotic stresses through sphingolipid metabolism and signaling network remains unclear. In this study, the sphingolipid pathway encompassing 134 genes was built and the transcript profiles of each gene in different tissues and under dehydration, salt, abscisic acid and cold stress were determined in Brassica napus.

Study on the alleviation of reactive oxygen species-mediated flunitrazepam toxicity in zebrafish (Danio rerio) by vitamin C and its mechanism.

The frequent detection of psychoactive drugs in aquatic environments has caused various toxic effects on aquatic organisms, highlighting the urgent need to explore remediation methods and mechanisms. Against the backdrop of toxicity induced by the typical benzodiazepine (BZD) flunitrazepam (FLZ) in zebrafish, this study evaluates the mitigating effects of vitamin C (VC) on FLZ-induced embryonic developmental toxicity, larval behavioral anomalies, apoptosis, oxidative stress, and mitochondrial dysfunction at environmentally relevant concentrations through reactive oxygen species (ROS)-mediated pathways. Furthermore, molecular dynamics simulations were utilized to decipher the mechanism underlying ROS inhibition.

Correlation cluster analysis of slope safety monitoring data in reservoir areas.

Current predictive methods for dam failures in reservoirs remain limited, indicating that the underlying mechanisms of such failures are not yet fully understood. To further elucidate the interrelationships among safety monitoring data in the reservoir area, this study established 36 monitoring cross-sections distributed across upper, middle, and lower slope zones. Each cross-section was instrumented with eight different types of monitoring devices.

Design of a Lorentz Force Magnetic Bearing Group Steering Law Based on an Adaptive Weighted Pseudo-Inverse Law.

Aiming at the high-precision torque output and saturation singularity avoidance problems in Lorentz force magnetic bearing (LFMB) swarms for magnetic levitation spacecraft, this study designs a manipulation law based on an adaptive weighted pseudo-inverse law. The system monitors each magnetic bearing's working state in real time using high-precision position and current sensors. As the key input for the adaptive weighted pseudo-inverse control law, the sensor data's measurement accuracy directly determines torque distribution effectiveness and attitude control precision.