Sugar-sweetened beverage consumption and depressive symptoms among college students in northeastern China: The mediating role of mobile phone use addiction.

Objective: Previous studies have explored the link between sugar-sweetened beverage (SSB) consumption and depressive symptoms, but the mediating role of Mobile Phone Use Addiction (MPUA) remains unclear. This study aims to examine how MPUA mediates the relationship between SSB consumption and depressive symptoms among college students in Northeast China.

Methods: A prospective study was conducted with first-year university freshmen across three northeastern Chinese provinces.

Comparative effects of arithmetic, speech, and motor dual-task walking on gait in stroke survivors: a cross-sectional study.

Background: The application of dual-task walking paradigms for gait assessment in stroke patients is critical, where varying concurrent tasks may elicit distinct gait patterns of dual-task interference. This study assessed the acute effects of different types of dual tasks on gait in stroke patients during task performance, informing occupational, and physical therapists about care recommendations to prevent patients from falling and improve their balance function in daily life.

Methods: A total of 19 stroke patients (52.

Epidemiology, antifungal susceptibility and biological characteristics of clinical Aspergillus fumigatus in a tertiary hospital.

Azole resistance in Aspergillus fumigatus poses a significant clinical challenge globally. In this study, we analyzed 307 clinical A. fumigatus isolates from General Hospital of Ningxia Medical University in China, collected between July 2023 and July 2024, to explore their susceptibility profiles, genotypic characteristics and biological traits.

Epidemiological characteristics of patients with invasive pulmonary aspergillosis infected with Aspergillus fumigatus from a tertiary hospital in Ningxia, China.

Invasive pulmonary aspergillosis (IPA) is a severe fungal infection primarily caused by Aspergillus fumigatus, representing a significant burden on public health. This study aims to address the limitations in the epidemiological characteristics, risk factors and diagnostic approaches for IPA by identifying clinical characteristics, laboratory findings, and chest CT imaging features that distinguish IPA from Aspergillus fumigatus colonization (AFC). We conducted a retrospective analysis of 249 hospitalized patients, including 77 with IPA and 172 with AFC, at Ningxia Medical University General Hospital from January 2018 to December 2023.

Association between gait characteristics during obstacle crossing and fall risk in stroke patients: A prospective cohort study.

Background: In daily life, stroke patients frequently experience falls during obstacle crossing. Analyzing the gait characteristics of patients in high-risk falling scenarios can help identify and predict fall risks.

Research Question: Exploring the predictive power of gait characteristics during obstacle crossing for fall risk in stroke patients.

The effects of cognitive dual-task gait training and motor dual-task gait training on lower-limb coordination during walking in subacute stroke patients: A randomized controlled trial.

Background: Dual-task gait training often improves walking ability in stroke patients, but its effect on lower-limb coordination and the effects of different training types remains unclear. Improving lower-limb coordination could decrease fall risk during walking.

Research Question: To observe the rehabilitation effect of cognitive dual-task gait training (CDTG) and motor dual-task gait training (MDTG) on lower-limb coordination during walking in subacute stroke patients.

Molecular and genetic features of a bla and bla coharboring hypermucoviscous Klebsiella pneumoniae of serotype K2 and ST65.

Purpose: This study aimed to assess the resistance phenotype, virulence phenotype, and genetic characteristics of a bla and bla co-harboring ST65 K2 Klebsiella pneumoniae (KP114), which was isolated from General hospital of Ningxia Medical University.

Methods: Antibiotic susceptibility test was determined by Vitek 2 Compact system. Multilocus Sequence typing (MLST), antimicrobial resistance and virulence genes were examined by PCR and Sanger sequencing.

Gait spatio-temporal characteristics during obstacle crossing as predictors of fall risk in stroke patients.

Background: Spatio-temporal parameters provide reference information for the gait variations of stroke patients during obstacle crossing. Analyzing these gait spatio-temporal characteristics of patients during obstacle crossing can assist in assessing the risk of falls. The aim of this study was to analyze the variances in gait spatio-temporal characteristics during obstacle crossing between stroke patients with and without a history of falls, to explore spatio-temporal parameters for assessing fall risk, and to construct a regression model for predicting patients' fall risk.

Biomimetic MOF Nanocarrier-Mediated Synergistic Delivery of Mitochondria and Anti-Inflammatory miRNA to Alleviate Acute Lung Injury.

Acute lung injury (ALI) is a clinically critical disease characterized by overwhelming inflammatory response and significant tissue damage with no specific treatment available currently. As a key player in the pathogenesis of ALI, macrophages are aberrantly activated and polarize toward the pro-inflammatory phenotypes, leading to overzealous inflammation and lung injury. Mitochondria is recognized as a crucial signaling hub governing macrophage function and polarization, deregulation of which is causatively related with defective metabolism of macrophages, deregulated inflammation, and hence ALI.

Genomic characterization of ST11-KL25 hypervirulent KPC-2-producing multidrug-resistant from China.

The global prevalence of ST11 hypervirulent carbapenem-resistant (hv-CRKP) isolates has been increasingly documented, yet genomic characterization of this clone remains insufficiently explored. Here, we report a clinical ST11-KL25 hv-CRKP strain (KP156) that exhibited resistance to multiple antibiotics and demonstrated hypervirulence in a mouse infection model. Whole-genome sequencing revealed that KP156 harbored one virulence plasmid (pKP156-Vir) and two resistance plasmids (pKP156-KPC and pKP156-tetA).

Indole-3-Aldehyde alleviates lung inflammation in COPD through activating Aryl Hydrocarbon Receptor to inhibit HDACs/NF-κB/NLRP3 signaling pathways.

Indole-3-aldehyde (I3A) is an intestinal microbial metabolite that regulates inflammation in various inflammatory diseases; however, its role in chronic obstructive pulmonary disease (COPD) remains unclear. This study aimed to investigate the anti-inflammatory effects and molecular mechanisms of I3A in COPD. We constructed in vivo models using cigarette smoke (CS)-stimulated mice and in vitro models using cigarette smoke extract (CSE)-stimulated MH-S cells.

Immediate changes in stroke patients' gait following the application of lower extremity elastic strap binding technique.

Objective: To ascertain the immediate changes in stroke patients' temporal and spatial parameters of gait and the joint angles of stroke patients throughout the entire gait cycle following the application of lower extremity elastic strap binding technique.

Methods: Twenty-nine stroke patients were invited as the study participants. The patient seated, flexed the hip and knee, utilized a 5 cm-wide elastic strap, positioning its midpoint beneath the affected foot and crossing it anterior to the ankle joint.

Psychometric properties of the chinese version of the value-based stigma inventory (VASI): a translation and validation study.

Objective: This study aimed to develop a culturally adapted Chinese version of the Value-based Stigma Inventory (VASI) and to evaluate its psychometric properties, including reliability and validity, among the general Chinese population.

Methods: This study is a cross-sectional study. Convenience sampling was used to recruit 708 general citizens from Shenyang City, Liaoning Province, China.

METTL16 deficiency attenuates apoptosis through translational control of extrinsic death receptor during nutrient deprivation.

METTL16 is a well-characterized mA methyltransferase that has been reported to contribute to tumorigenesis in various types of cancer. However, the effect of METTL16 on tumor progression under restricted nutrient conditions, which commonly occur in tumor microenvironment, has yet to be elucidated. Herein, our study initially reported the inhibitory effect of METTL16 depletion on apoptosis under amino acid starvation conditions.

Tetramerization of pyruvate kinase M2 attenuates graft-versus-host disease by inhibition of Th1 and Th17 differentiation.

Lethal graft-versus-host disease (GVHD) is the major complication of allogeneic hematopoietic stem-cell transplantation (Allo-HSCT). Pyruvate kinase M2 (PKM2) is essential for CD4+ T-cell differentiation. Using the well-characterized mouse models of Allo-HSCT, we explored the effects of TEPP-46-induced PKM2 tetramerization on GVHD and graft-versus-leukemia (GVL) activity.

The impact of whole-body vibration training and proprioceptive neuromuscular facilitation on biomechanical characteristics of lower extremity during cutting movement in individuals with functional ankle instability: A parallel-group study.

Background: We compared the effects of whole-body vibration training and proprioceptive neuromuscular facilitation on the biomechanical characteristics of the lower limbs in functional ankle instability patients during cutting movement to ascertain the superior rehabilitation method.

Methods: Twenty-two male College students with unilateral functional ankle instability volunteered for this study and were randomly divided into whole-body vibration training group and proprioceptive neuromuscular facilitation group. Kinematics data and ground reaction forces were collected using infrared motion capture system and 3-D force plates synchronously during cutting.

Epidemiology and Azole Resistance of Clinical Isolates of from a Large Tertiary Hospital in Ningxia, China.

Purpose: The objective of this study was to determine the clinical distribution, in vitro antifungal susceptibility and underlying resistance mechanisms of () isolates from the General Hospital of Ningxia Medical University between November 2021 and May 2023.

Methods: Antifungal susceptibility testing was performed using the Sensititre YeastOne YO10, and isolates with high minimal inhibitory concentrations (MICs) were further confirmed using the standard broth microdilution assays established by the Clinical and Laboratory Standards Institute (CLSI) M38-third edition. Whole-Genome Resequencing and RT-qPCR in azole-resistant strains were performed to investigate the underlying resistance mechanisms.

gene enhances drought tolerance via modulating flavonoid biosynthesis in .

Karst lands provide a poor substrate to support plant growth, as they are low in nutrients and water content. Common buckwheat () is becoming a popular crop for its gluten-free grains and their high levels of phenolic compounds, but buckwheat yields are affected by high water requirements during grain filling. Here, we describe a wild population of drought-tolerant and its potential for enhancing drought tolerance in cultivated buckwheat.

Sodium butyrate (SB) ameliorated inflammation of COPD induced by cigarette smoke through activating the GPR43 to inhibit NF-κB/MAPKs signaling pathways.

Cigarette smoke is recognized as a major trigger for individuals with chronic obstructive pulmonary disease (COPD), leading to an amplified inflammatory response. The onset and progression of COPD are affected by multiple environmental and genetic risk factors, such as inflammatory mechanisms, oxidative stress, and an imbalance between proteinase and antiprotease. As a result, conventional drug therapies often have limited effectiveness.

Epitaxial grown [hk1] oriented 2D/1D BiOS/SbS heterostructure with significantly enhanced photoelectrochemical performance.

Bismuth oxysulfide (BiOS) is a layered material with high carrier mobility, excellent light absorption characteristic and good stability. However, there are few reports about the use of BiOS in photoelectrochemical (PEC) water splitting. In this paper, BiOS nanosheets (NSs) films were prepared on FTO substrates by one-step hydrothermal method, which broke the traditional powder state of BiOS prepared.

Acute effects of Kinesio Taping on lower-limb coordination of gait in hemiplegic patients.

Background: Kinesio taping can effectively strengthen weakened muscles, increase walking speed, and improve dynamic balance in hemiplegic patients, but its effect on lower-limb coordination is not clear. Improving lower-limb coordination in hemiplegic patients can decrease risk of fall during walking.

Research Question: This study utilized continuous relative phase to depict the pattern and variability of lower-limb coordination in hemiplegic patients and healthy subjects during walking, and investigate whether it has the acute effect of Kinesio Taping on lower-limb coordination in hemiplegic patients during walking.

METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2.

N-methyladenosine (mA) plays crucial roles in regulating RNA metabolisms. METTL16 identified as a single-component methyltransferase catalyzes mA formation in the nucleus; whether it regulates cytoplasmic RNA fate remains unknown. Here, we detected the dual localization of METTL16 in the nucleus and cytoplasm.

Comparison of pulmonary function during interscalene block vs. supraclavicular block: a single-center, double-blind, randomized trial.

Backround: The supraclavicular plexus block (SCB) and interscalene plexus block (ISB) have the potential to pulmonary function, the duration of the potential remains uncertain. So, we compared the effect of SCB and ISB on pulmonary function, especially the duration time.

Methods: Ninety-six patients were finally allocated to group I and group S.

Association of Type D personality and mild cognitive impairment in patients with hypertension.

Objective: The aim of this study was to evaluate the association between Type D personality and mild cognitive impairment (MCI) in patients with hypertension.

Methods: A total of 324 subjects with hypertension were included in the study. All of them completed questionnaires on demographic characteristics, Type D personality Scale, Montreal Cognitive Assessment (MoCA), Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI).