3‑Phenethyl-2-phenylquinazolin-4(3)‑one Inhibits Breast Cancer Cell Motility, Energy Metabolism, and Proliferation by Inactivating Phosphoinositide 3‑Kinase/Protein Kinase B and Epidermal Growth Factor Receptor Pathways.

Marine-derived compounds hold great promise for cancer therapy, targeting various essential processes in cancer progression, such as apoptosis, metastasis, proliferation, and drug resistance. 3-Phenethyl-2-phenylquinazolin-4-(3)-one () is a natural quinazolinone derivative extracted from the marine sediment-derived genus sp. CNQ-049.

An Endolichenic Fungi-Derived Fatty Acid, cis-10-Nonadecenoic acid, Suppresses Colorectal Cancer Stemness.

Endolichenic fungi (ELF), symbionts of lichens, have been reported to produce diverse bioactive secondary metabolites with promising pharmaceutical potential. In this study, we isolated and identified an ELF, EL001668 (KACC 83020BP), from Rass., and assessed its crude extract and bioactive compounds against colorectal cancer (CRC) stem cell activity.

Structure Characterization and Antibacterial, Antifungal, and Antiquorum-Sensing Activity of New Metabolites From the Lipophilic Fractions of Platycodon grandiflorum Root.

The root of Platycodon grandiflorum has long been used as a vegetable and traditional medicine. Although the antibacterial activity of the plant's lipophilic (hexanes and dichloromethane) fractions has been reported, the specific antibacterial compounds have not been identified. In this study, chemical analysis of the lipophilic fractions of P.

Configurational assignments of type-I polyketide synthase (PKS)-derived natural products based on spectroscopic and chemical analysis: methodologies and case studies.

Covering: 1992 to 2024Type-I polyketide synthase (PKS)-derived metabolites are structurally diverse bioactive natural products containing multiple stereogenic centres. This review focuses on the configurational analysis of type-I PKS-derived natural products, emphasizing the methodologies and challenges associated with determining their stereochemistry due to their complex structures with multiple chiral centres. Key strategies include -based configuration analysis (JBCA), chemical derivatizations with chiral reagents, degradation methods, NMR spectroscopic analysis, and the exploitation of chiroptical properties.

Three New Depsipeptides, Homiamides A-C, Isolated from sp., ROA-065.

Three new depsipeptides, homiamides A-C (-), were isolated from a marine sediment-derived strain of sp., ROA-065. The planar structures of homiamides A-C (-) were elucidated using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopic data.

Caboxamycin Inhibits Heart Inflammation in a Coxsackievirus B3-Induced Myocarditis Mouse Model.

Coxsackievirus B3 (CVB3) is a positive single-strand RNA genome virus which belongs to the enterovirus genus in the picornavirus family, like poliovirus. It is one of the most prevalent pathogens that cause myocarditis and pancreatitis in humans. However, a suitable therapeutic medication and vaccination have yet to be discovered.

Anti-Melanogenic Activity of Undecylprodigiosin, a Red Pigment Isolated from a Marine sp. SNA-077.

Bioassay and HPLC-UV guided fractionations of the crude extract of marine-derived sp. SNA-077 have led to the isolation of a red pigment, undecylprodigiosin . The chemical structure of undecylprodigiosin was revealed by the interpretation of NMR and mass spectroscopic (MS) data.

The discovery of an anti-inflammatory monoterpenoid, neoroseoside from the Zea mays.

A new monoterpenoid, neoroseoside (1), along with two previously reported compounds, 2″-O-α-l-rhamnosyl-6-C-fucosylluteolin (2) and farobin A (3) were isolated from the Zea mays. The structure of compound 1 was determined through the analysis spectroscopic data, including mass spectrometry (MS), infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR) data. The absolute configurations of 1 were deduced from the comparing the values of optical rotations and from the interpretation of electronic circular dichroism (ECD) spectra.

Methylanthranilate, a Food Fragrance Attenuates Skin Pigmentation through Downregulation of Melanogenic Enzymes by cAMP Suppression.

Methyl anthranilate (MA) is a botanical fragrance used in food flavoring with unexplored potential in anti-pigment cosmetics. MA dose-dependently reduced melanin content without affecting cell viability, inhibited dendrite elongation and melanosome transfer in the co-culture system of human melanoma cells (MNT-1) and human keratinocyte cell line (HaCaT), and downregulated melanogenic genes, including tyrosinase, tyrosinase-related protein 1 and 2 (TRP-1, TRP-2). Additionally, MA decreased cyclic adenosine monophosphate (cAMP) production and exhibited a significant anti-pigmentary effect in Melanoderm™.

Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells.

A HPLC-UV guided fractionation of the culture broth of sp. CNQ-617 has led to the isolation of a new quinazolinone derivative, actinoquinazolinone (), as well as two known compounds, 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one () and 7-methoxy-8-hydroxy cycloanthranilylproline (). The interpretation of 1D, 2D NMR, and MS spectroscopic data revealed the planar structure of .

Safety assessment of Cnidium officinale rhizome extract in cosmetics using the Threshold of Toxicological Concern (TTC) approach.

Cosmetics often contain botanical extracts, which present a challenge for safety assessors due to their complex composition. The threshold of toxicological concern (TTC) approach is considered as a solution for the safety assessment of botanical extracts in cosmetics as part of next-generation risk assessment. In this study, we applied the TTC approach to evaluate the safety of Cnidium officinale rhizome extract (CORE), a widely used botanical extract in skin conditioning products.

Seed Extract Inhibits AIM2-Inflammasome Activation and Attenuates Imiquimod-Induced Psoriasis-like Skin Inflammation.

The AIM2 inflammasome is an innate immune system component that defends against cytosolic bacteria and DNA viruses, but its aberrant activation can lead to the progression of various inflammatory diseases, including psoriasis. However, there have been few reports of specific inhibitors of AIM2 inflammasome activation. In this study, we aimed to investigate the inhibitory activity of ethanolic extracts of seeds of (CO), a herb and food plant used in traditional medicine, on AIM2-inflammasome activation.

Marinobazzanan, a Bazzanane-Type Sesquiterpenoid, Suppresses the Cell Motility and Tumorigenesis in Cancer Cells.

Marinobazzanan (), a new bazzanane-type sesquiterpenoid, was isolated from a marine-derived fungus belonging to the genus . The chemical structure of was elucidated using NMR and mass spectroscopic data, while the relative configurations were established through the analysis of NOESY data. The absolute configurations of were determined by the modified Mosher's method as well as vibrational circular dichroism (VCD) spectra calculation and it was determined as 6, 7, 9, and 10.

Lodopyridones D - G from a marine-derived bacterium Saccharomonospora sp.

The intensive investigation of chemical components from the culture broth of the bacterium sp. CNQ-490 has yielded four new natural products, lodopyridones D - G () along with the previously reported compounds, lodopyridones A - C () and cotteslosin A (). The planar structures of the lodopyridones D - G () were elucidated by interpreting the mass spectrometry, ultraviolet (UV) spectroscopy, and 1D and 2D nuclear magnetic spectroscopy (NMR) data, as well as comparing NMR data with those of the lodopyridones A - C ().

SNA077, an Extract of Marine sp., Inhibits Melanogenesis by Downregulating Melanogenic Proteins via Inactivation of cAMP/PKA/CREB Signaling.

Excess melanin in skin is known to be the main cause of hyper-pigmentary skin diseases such as freckles and lentigo. This study aimed to evaluate the depigmenting efficacy of an extract from the marine microorganism strain, sp. SNA077.

Actinopolymorphols E and F, pyrazine alkaloids from a marine sediment-derived bacterium Streptomyces sp.

HPLC-UV-guided fractionation of crude extract from the marine sediment-derived bacterium Streptomyces sp. CNP-944 has yielded two new pyrazine alkaloids, actinopolymorphols E and F (1 and 2), in addition to the previously reported biosynthetic product, actinopolymorphol G (3), and the known actinopolymorphol D (4). The chemical structures of 1-3 were determined based on the interpretation of the 1D, 2D NMR, and MS spectroscopic data.

Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived sp. CNQ-617.

The tricyclic quinazoline alkaloid deoxyvasicinone (, ) was isolated from a marine-derived sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH).

Marine Depsipeptide Nobilamide I Inhibits Cancer Cell Motility and Tumorigenicity via Suppressing Epithelial-Mesenchymal Transition and MMP2/9 Expression.

A cyclic depsipeptide, nobilamide I (), along with the known peptide A-3302-B/TL-119 (), was isolated from the saline cultivation of the marine-derived bacterium sp., strain CNQ-490. The planar structure of was elucidated by interpretation of 1D and 2D NMR and MS spectroscopic data.

Saccharobisindole, Neoasterric Methyl Ester, and 7-Chloro-4(1H)-quinolone: Three New Compounds Isolated from the Marine Bacterium sp.

Analysis of the chemical components from the culture broth of the marine bacterium sp. CNQ-490 has yielded three novel compounds: saccharobisindole (), neoasterric methyl ester (), and 7-chloro-4()-quinolone (), in addition to acremonidine E (), pinselin (), penicitrinon A (), and penicitrinon E (). The chemical structures of the three novel compounds were elucidated by the interpretation of 1D, 2D nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS) data.

Antibacterial Meroterpenoids, Merochlorins G-J from the Marine Bacterium sp.

Four new chlorinated meroterpenoids, merochlorins G-J (-), and , a dihydronaphthalenedione precursor, along with known merochlorins A () and C-F (-), were obtained from cultivation of the bacterium strain sp. CNH-189, which was isolated from marine sediment. The planar structures of compounds - and were elucidated by interpretation of MS, UV, and NMR spectroscopic data.

Potent and Selective Inhibitors of Human Monoamine Oxidase A from an Endogenous Lichen Fungus .

Using 126 endogenous lichen fungus (ELF) extracts, inhibitory activities against monoamine oxidases (MAOs) and cholinesterases (ChEs) were evaluated. Among them, extract ELF29 of the endogenous fungus of the lichen showed the highest inhibitory activity against hMAO-A. Compounds alternariol (AT), 5'-hydroxy-alternariol (HAT), and mycoepoxydiene (MED), isolated from the extract, had potent inhibitory activities against hMAO-A with IC values of 0.

Chemical Structure and Biological Activities of Secondary Metabolites from L.

L. is a halophyte that grows in salt marshes and muddy seashores, which is widely used both as traditional medicine and as an edible vegetable. This salt-tolerant plant is a source of diverse secondary metabolites with several therapeutic properties, including antioxidant, antidiabetic, cytotoxic, anti-inflammatory, and anti-obesity effects.

Androsamide, a Cyclic Tetrapeptide from a Marine sp., Suppresses Motility of Colorectal Cancer Cells.

A cyclic tetrapeptide, androsamide (), was isolated from a marine actinomycete of the genus , strain CNT-189. The planar structure of was assigned by the interpretation of 1D and 2D NMR spectroscopic data. The absolute configurations of constituent amino acids of were determined by application of the Marfey's and advanced Marfey's methods.

An Activatable AIEgen Probe for High-Fidelity Monitoring of Overexpressed Tumor Enzyme Activity and Its Application to Surgical Tumor Excision.

Monitoring fluctuations in enzyme overexpression facilitates early tumor detection and excision. An AIEgen probe (DQM-ALP) for the imaging of alkaline phosphatase (ALP) activity was synthesized. The probe consists of a quinoline-malononitrile (QM) core decorated with hydrophilic phosphate groups as ALP-recognition units.