Inflamed Pathways to Motherhood: Evaluating Obstetric and Neonatal Outcomes in Rheumatic Pregnancies.

This study aims to evaluate obstetric and neonatal outcomes in pregnancies complicated by RDs and to identify hemogram-derived biomarkers associated with adverse perinatal events. This retrospective cohort study analyzed 360 pregnancies in individuals diagnosed with rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), ankylosing spondylitis (AS), Sjögren's disease, sarcoidosis, undifferentiated connective tissue disease (UCTD), and other autoimmune conditions, followed up at the Department of Obstetrics and Gynecology, Ankara University Faculty of Medicine, between 2013 and 2018. Data on disease activity, maternal complications, neonatal outcomes, and inflammatory markers were extracted from electronic medical records.

Predicting fracture toughness of human cortical bone from donors with and without type 2 diabetes using Raman spectroscopy and machine learning.

Type 2 diabetes mellitus (T2DM) is associated with increased skeletal fragility, yet standard clinical assessments often fail to detect diabetes-induced changes in bone quality. Raman spectroscopy (RS), a label-free and non-destructive technique, offers insight into bone composition, and its full spectral profile may reveal changes not captured by traditional compositional metrics. Prior to propagating a crack from a micro-notch to failure, we acquired RS data from human cortical bone samples extracted from fresh-frozen, cadaveric femurs: 60 non-diabetic donors and 60 T2DM donors (equal number of females and males between 50 years and 97 years of age).

MammosighTR: Nationwide Breast Cancer Screening Mammogram Dataset with BI-RADS Annotations for Artificial Intelligence Applications.

. The MammosighTR dataset, derived from Türkiye's national breast cancer screening mammography program, provides BI-RADS-labeled mammograms with detailed annotations on breast composition and lesion quadrant location, which may be useful for developing and testing AI models in breast cancer detection. ©RSNA, 2025.

An Endolichenic Fungi-Derived Fatty Acid, cis-10-Nonadecenoic acid, Suppresses Colorectal Cancer Stemness.

Endolichenic fungi (ELF), symbionts of lichens, have been reported to produce diverse bioactive secondary metabolites with promising pharmaceutical potential. In this study, we isolated and identified an ELF, EL001668 (KACC 83020BP), from Rass., and assessed its crude extract and bioactive compounds against colorectal cancer (CRC) stem cell activity.

A Marine-Derived Steroid from sp., 3,12-Dioxochola-4,6-dien-24-oic Acid, Enhances Skin Re-Epithelialization and Tissue Repair.

The discovery of bioactive natural compounds from microbes holds promise for regenerative medicine. In this study, we identified and characterized a steroid-like compound, 3,12-dioxochola-4,6-dien-24-oic acid (DOCDA), from a crude extract of sp. DOCDA significantly promoted wound healing by enhancing HaCaT cell invasion and migration.

Causes of diagnostic and treatment delays in locally advanced breast cancer: a nationwide multicenter survey and electronic health records analysis in Turkiye.

Delays in breast cancer (BC) diagnosis and treatment negatively impact survival outcomes. Understanding patient- and provider-related factors behind these delays is crucial. This study aimed to identify nationwide reasons for delayed diagnosis and treatment of locally advanced BC in Turkiye.

Development and psychometric evaluation of transition of care for older adults scale: Barriers and facilitators (TOCAS-BF).

Background: Healthcare systems strive to improve hospital-to-home transitions for older adults, but existing tools often miss key facilitators and barriers. Therefore, this study aimed to develop a tool for assessing the facilitators of and barriers to effective transitional care for older adults and to evaluate its psychometric properties.

Methods: A methodological study was conducted from September 2023 to February 2024 with 229 older adult volunteers to develop and test the tool.

Strictosamide and mitraphylline inhibit cancer cell motility by suppressing epithelial-mesenchymal transition via integrin α4-mediated signaling.

Epithelial-mesenchymal transition (EMT) is a critical process in cancer cell motility and metastasis. Monoterpene indole alkaloids (MIAs) have been widely investigated for biological activities, but rarely been explored for cell motility inhibition. This study aimed to discover natural products, especially focusing on MIAs, that inhibit EMT in cancer cells, based on our screening using multiple plant extracts.

4-O-Demethylbarbatic acid has a novel therapeutic impact on the progression of EGFR-driven lung adenocarcinoma.

Background: 4-O-Demethylbarbatic acid (4O-DBA), a secondary metabolite derived from lichen species, has shown inhibitory activity of epstein-barr virus (EBV), indicating its potential in cancer prevention or treatment. However, the mechanisms underlying its anti-cancer effects, particularly in non-small cell lung cancer (NSCLC), remain unclear.

Purpose: We investigated the anti-cancer activity of 4O-DBA-driven EGFR inhibition on cancer metastasis and tumorigenicity of NSCLC cells A549 (EGFR-wild type), H1975 (L858R mutant), PC9 (EGFR exon 19 deletion) and PC9/GR (gefitinib resistant) cells.

Determining the optimal follow-up protocol after primary surgery in patients with early-stage endometrial cancer.

Objective: The aim of this study was to investigate the timing of recurrence in patients with early-stage endometrial cancer and to determine the optimal postoperative follow-up protocol for the detection of recurrence.

Material And Methods: Patients with stage 1 and 2, grade 1-3 endometrioid type endometrial cancer who underwent follow-up for at least two years were included. The diagnostic method for recurrence was analyzed for each patient.

Computer-Aided Decision Support Systems of Alzheimer's Disease Diagnosis - A Systematic Review.

Background And Objective: The incidence of Alzheimer's disease is rising with the increasing elderly population worldwide. While no cure exists, early diagnosis can significantly slow disease progression. Computer-aided diagnostic systems are becoming critical tools for assisting in the early detection of Alzheimer's disease.

Risk factors and risk-indicating model for early-onset neonatal sepsis after preterm prelabor rupture of membranes: A historical cohort study.

Introduction: Early-onset neonatal sepsis (EONS) is an important cause of neonatal morbidity and mortality and is strongly associated with intra-amniotic infection. The risk of intra-amniotic infection increases after preterm prelabor rupture of membranes (PPROM). Better tools are needed for monitoring women with PPROM for intra-amniotic infection and identifying those at high risk of EONS so that intervention can be made timely.

Development of content for a mobile application aimed to increase medication adherence among older adults.

Background: An increase in the use of health-related mobile applications is expected in the future. It is believed that mobile applications are valuable tools for patients, caregivers, and healthcare professionals. The use of mobile applications to improve medication adherence in older adults is effective, but it must be developed based on the special needs of older adults for high quality and long-term use.

Tolerance Evaluation of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children: Is Age the Crucial Factor?

Introduction: Little is known about the natural history of pediatric nonsteroidal anti-inflammatory drug hypersensitivity (NSAID-H). The aim of this prospective study was to evaluate tolerance development in pediatric patients with confirmed, immediate NSAID-H and to determine the risk factors for NSAID-H persistence.

Methods: Children with a confirmed diagnosis of NSAID-H were assessed for tolerance by drug provocation test (DPT) at least 3 years after diagnosis.

Mechanisms of Endometrioma-Mediated Ovarian Damage: Myths and Facts.

Ovarian endometriomas (OEMs), cystic formations within the ovaries, are a significant manifestation of endometriosis and present in 20-40% of affected women. Despite extensive research, the pathogenesis of endometriosis remains unclear, with retrograde menstruation, coelomic metaplasia, and lymphatic dissemination being proposed mechanisms. OEMs negatively impact ovarian function by reducing the ovarian reserve, disrupting folliculogenesis, and altering the ovarian microenvironment through oxidative stress, inflammation, and fibrosis.

Mediators affecting the higher risk of stillbirth among foreign-born women in Sweden: A nationwide cohort study.

Introduction: In Sweden, a higher incidence of stillbirth has been observed among women originating from sub-Saharan Africa and the Middle East. In this nationwide cohort of more than 2 million births, we assessed the risk factors for stillbirth among foreign-born women with the aim of understanding which mediators have the largest impact on the elevated risk of stillbirth.

Material And Methods: This was a nationwide cohort study in Sweden including 2 300 391 births between 2000 and 2021.

Development and synthesis of diffractaic acid analogs as potent inhibitors of colorectal cancer stem cell traits.

In recent years, evidence for the anti-cancer activity of lichen secondary metabolites has been rapidly increasing. In this study, we synthesised analogues of diffractaic acid, a lichen secondary metabolite, and evaluated their ability to suppress colorectal cancer stem potential. Among the 10 compounds after H/CH₃/benzylation of the diffractaic acid structure or modifications in an aromatic hydrophobic domain, TU3 has a more inhibition effect on the stem potential of colorectal cancer compared to other compounds.

Lobaric acid suppresses the stemness potential of colorectal cancer cells through mTOR/AKT.

Stereocaulon alpinum has been found to have potential pharmaceutical properties due to the presence of secondary metabolites such as usnic acid, atranorin, and lobaric acid (LA) which have anticancer activity. On the other hand, the effect of LA on the stemness potential of colorectal cancer (CRC) cells remains unexplored, and has not yet been thoroughly investigated. In this study, we examined the inhibitory activity of LA from Stereocaulon alpinum against the stemness potential of CRC cells and investigated the possible underlying mechanisms.

Turkish Validation and Reliability Analysis of the International Female Coital Incontinence Questionnaire.

Introduction And Hypothesis: Coital incontinence (CI) is an important problem that negatively affects women's quality of life and is often underreported owing to embarrassment, indicating the importance of its assessment with validated questionnaires. The aim of this study was to validate the Turkish-translated version of the International Female Coital Incontinence Questionnaire (IFCI-Q) for the objective evaluation of women with CI in Turkish-speaking populations.

Methods: Ninety women with CI filled out the Turkish-translated version of IFCI-Q.

Ethanol Sclerotherapy for Endometriomas in Infertile Women: A Narrative Review.

Ethanol sclerotherapy (EST) has gained attention as a minimally invasive treatment option for ovarian endometriomas, particularly in infertile women with endometrioma undergoing in vitro fertilization (IVF). Endometriomas are associated with decreased ovarian reserve and impaired fertility outcomes, and traditional surgical approaches, such as cystectomy, often lead to further reductions in ovarian reserve. Ethanol sclerotherapy offers a potential alternative that preserves ovarian function while effectively managing endometriomas.

Impact of Length Indexing of Deformation in Echocardiographic Evaluation of Right Ventricular Function.

Background: When assessing right ventricular (RV) function by echocardiography, some discordance between the deformational indices is predicted on the basis of the influence of RV length. RV free wall longitudinal strain (RVFWS) is relatively independent of RV length, whereas tricuspid annular plane systolic excursion (TAPSE) reflects the strain-length product. Systolic annular velocity (s'; distance over time) is also likely to be influenced by length.

TDO2 inhibition counters Benzo[a]pyrene-induced immune evasion and suppresses tumorigenesis in lung adenocarcinoma.

Introduction: Benzo[a]pyrene (BaP) is a toxic polycyclic aromatic hydrocarbon known as an exogenous AhR ligand. This study investigates the role of BaP in inducing immune checkpoint expression in lung adenocarcinoma (LUAD) and the underlying mechanisms involving the aryl hydrocarbon receptor (AhR) and tryptophan (Trp) metabolism.

Methods: We assessed the expression of immune checkpoint molecules, including PD-L1 and ICOSL, in lung epithelial cell lines (BEAS-2B and H1975) exposed to BaP.

Emodin disrupts the KITENIN oncogenic complex by binding ErbB4 and suppresses colorectal cancer progression in dual blockade with KSRP-binding compound.

Background: The KITENIN/ErbB4 complex has been reported to participate in metastasis, which is the principal reason of death in most colorectal cancer patients.

Purpose: New therapeutics need to be developed to suppress the malignant effects of the KITENIN/ErbB4 complex, which is related to drug resistance. The present study aimed to evaluate changes in cancer cell invasion capacity, transcriptional regulators, and cellular bioenergetics after targeting the KITENIN/ErbB4 complex with emodin.

Unveiling the antimetastatic activity of monoterpene indole alkaloids targeting MMP9 in cancer cells, with a focus on pharmacokinetic and cellular insights.

Distant metastasis, together with acquired resistance, limits the therapeutic impact of chemotherapy and molecularly targeted therapies. The properties of the tumor microenvironment determine how sensitive or resistant various cancers are to specific pharmacological treatments. Matrix metalloproteinase 9 (MMP9) is widely known for its ability to break down the extracellular matrix and it also modulates the motility of cancer cells.