Publications by authors named "Suresh R Bhosle"
In recent years, evidence for the anti-cancer activity of lichen secondary metabolites has been rapidly increasing. In this study, we synthesised analogues of diffractaic acid, a lichen secondary metabolite, and evaluated their ability to suppress colorectal cancer stem potential. Among the 10 compounds after H/CH₃/benzylation of the diffractaic acid structure or modifications in an aromatic hydrophobic domain, TU3 has a more inhibition effect on the stem potential of colorectal cancer compared to other compounds.
View Article and Find Full Text PDFThe anticancer therapeutic effects of usnic acid (UA), a lichen secondary metabolite, have been demonstrated and . However, the mechanism underlying the anticancer effect of UA remains to be clarified. In this study, the target protein of UA was identified using a UA-linker-Affi-Gel molecule, which showed that UA binds to the 14-3-3 protein.
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- Atraric acid (AA) is a phenolic compound that shows anti-androgen properties, making it suitable for a new topical treatment for alopecia.
- The optimized formulation, AA-TF#15, demonstrated significantly improved absorption and drug deposition in the skin compared to a conventional AA solution, specifically showing an 8.77-fold increase in skin flux.
- Tested on mice, AA-TF#15 resulted in a substantial 58.0% increase in hair regrowth compared to minoxidil and showed enhanced expression of proteins related to hair growth, indicating its potential as an effective treatment for androgenic alopecia.
Lichens produce various unique chemicals that are used in the pharmaceutical industry. To screen for novel lichen secondary metabolites that inhibit the stemness potential of colorectal cancer cells, we tested acetone extracts of 11 lichen samples collected in Chile. Tumidulin, isolated from sp.
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