Percutaneous Endoscopic Lumbar Discectomy via Sacral Ala-Transverse Process Approach for the Treatment of Far Lateral Disc Herniation at L5/S1:A technical note and case series.

Study Design: Technical note BACKGROUND: Far lateral L5/S1 disc herniations are challenging due to the high iliac crest and enlarged L5 transverse process blocking the transforaminal corridor. This study introduces a percutaneous endoscopic discectomy via sacral ala-transverse process approach to overcome these challenges while preserving spinal stability.

Methods: Patients with far lateral L5/S1 disc herniations underwent percutaneous endoscopic discectomy through sacral ala-transverse process approach under fluoroscopic guidance.

The impact of halo-pelvic traction on deformity correction and bone mineral density in patients with severe spine deformity.

Background: Severe spinal deformities require surgical intervention, with preoperative traction commonly used to improve spinal flexibility and surgical safety. However, the impact of traction on bone mineral density (BMD) and its relationship with correction outcomes remains poorly understood.

Methods: This retrospective study analyzed patients with severe spinal deformities who underwent halo-pelvic traction before surgical correction.

Comparative efficacy and safety of different tranexamic acid administration in spine surgery: a network meta-analysis.

Background: Tranexamic acid (TXA) is widely used to reduce blood loss in spine surgery. Different administration routes, including intravenous (IV), topical, and oral, have been studied, but a comprehensive comparison of their efficacy and safety remains lacking. This network meta-analysis aims to compare the effectiveness and safety of various TXA administration methods in spine surgery, focusing on blood loss, transfusion rates and other perioperative parameters.

Low Bone Mineral Density as a Risk Factor for Cervical Sagittal Imbalance Following Laminoplasty.

Objective: To investigate the influence of preoperative bone mineral density (BMD) on cervical sagittal balance changes following laminoplasty and identify potential risk factors for postoperative cervical sagittal imbalance (CSI).

Methods: We retrospectively analyzed 104 patients with cervical spondylotic myelopathy (CSM) who underwent multilevel (≥3 levels) cervical laminoplasty between January 2015 and December 2022. Cervical vertebral BMD is measured using computed tomography (CT) and expressed in Hounsfield Units (HU).

Efficacy and safety of ultrasound-guided compared to x-ray-guided percutaneous endoscopic lumbar discectomy in China: a systematic review and pooled analysis.

Background: Percutaneous endoscopic lumbar discectomy (PELD) has become the preferred minimally invasive surgical treatment for lumbar disc herniation. This study aims to conduct a systematic literature review and meta-analysis to assess the efficacy and safety of ultrasound-guided PELD compared to x-ray-guided PELD.

Methods: A comprehensive literature search was conducted in the PubMed, Cochrane Library, Ovid:MEDLINE, Embase, and China National Knowledge Infrastructure databases up to August 2024.

Cervical Subcutaneous Fat Thickness and Its Association with Sagittal Parameters and Clinical Outcomes Following Laminoplasty in Patients with Cervical Spondylotic Myelopathy.

Objective: To investigate the association between cervical subcutaneous fat thickness, sagittal alignment parameters, and clinical outcomes following laminoplasty in patients with cervical spondylotic myelopathy (CSM).

Methods: A total of 131 patients with CSM who underwent single-door cervical laminoplasty between January 2021 and June 2023 were retrospectively analyzed, with an average follow-up period of 14.02 ±1.

Anti-Osteoporosis Is Imperative in Prevention of Progress of Ankylosing Spondylitis.

Background: Ankylosing spondylitis (AS) is a chronic autoimmune disease that affects the spine and peripheral joints, often leading to kyphosis, joint stiffness, and even ankylosis. Sagittal parameters, such as total thoracic kyphosis (TTK), thoracic kyphosis (TK), major thoracic kyphosis (MTK), and thoracolumbar kyphosis (TLK), are crucial indices for evaluating spinal alignment in AS patients and can reflect disease progression. This study aims to explore the relationship between bone mineral density (BMD), sagittal parameters, and joint ankylosis in AS patients.

Comparison of Safety and Efficacy of Anesthesia Methods in Percutaneous Endoscopic Lumbar Discectomy: A Network Meta-Analysis.

The objective of this study was to systematically evaluate the safety and efficacy of local anesthesia, general anesthesia, and epidural anesthesia in percutaneous endoscopic lumbar discectomy (PELD). We searched PubMed, EMBASE, and OVID databases for all relevant studies. All statistical analysis was performed using STATA 17.

Comparison of Percutaneous Transforaminal Endoscopic Discectomy and Microendoscopic Discectomy for the Surgical Management of Symptomatic Lumbar Disc Herniation: A Multicenter Retrospective Cohort Study with a Minimum of 2 Years' Follow-Up.

Background: Percutaneous transforaminal endoscopic discectomy (PTED) and microendoscopic discectomy (MED) are alternative minimally invasive procedures for the treatment of symptomatic lumbar disc herniation (LDH). However, insufficient literature exists to highlight the differences between the procedures.

Objectives: This study intended to clarify whether PTED results in better clinical outcomes compared with MED in the surgical management of single-level LDH.

Transforaminal Endoscopic Discectomy and Foraminoplasty for Treating Central Lumbar Stenosis.

Objective: Lumbar spinal stenosis is a medical condition characterized by the narrowing of the spinal canal as a consequence of bone and soft tissue degeneration, including disc herniation, facet and ligamentum flavum hypertrophy, and osteophyte formation. The percutaneous transforaminal endoscopic discectomy (PTED) technique is one of the emerging surgical alternatives for treating central lumbar stenosis. The present study aims to describe the present techniques of PTED and foraminoplasty for central lumbar stenosis, and discuss the feasibility and advantages of this technique.

Percutaneous Transforaminal Endoscopic Discectomy versus Micro-Endoscopic Discectomy for Lumbar Disc Herniation.

BACKGROUND Percutaneous transforaminal endoscopic discectomy (PTED) and micro-endoscopic discectomy (MED) are alternative minimally invasive, widely performed procedures for the treatment of lumbar disc herniation (LDH). This study compared the clinical outcomes of these 2 surgical techniques in treating LDH. MATERIAL AND METHODS A comprehensive literature search was performed in PubMed, MEDLINE, EMBASE, Cochrane, and Google Scholar to identify all relevant studies comparing PTED and MED in treating LDH.

Polyethylene glycol modified magnetic carbon nanotubes as nanosorbents for the determination of methylprednisolone in rat plasma by high performance liquid chromatography.

In this paper, polyethylene glycol modified (PEGylated) magnetic carbon nanotubes were developed as solid-phase extraction nanosorbents for the determination of methylprednisolone in rat plasma. The procedure mainly involved two steps including preparation of PEGylated magnetic nanosorbents and bioanalysis. Monodisperse magnetites (Fe3O4) anchored onto multi-walled carbon nanotubes (MWCNTs) were synthesized by a facile solvothermal synthesis method.

A dual functional fluorescent probe for glioma imaging mediated by blood-brain barrier penetration and glioma cell targeting.

Glioma is a huge threat for human being because it was hard to be completely removed owing to both the infiltrating growth of glioma cells and integrity of blood brain barrier. Thus effectively imaging the glioma cells may pave a way for surgical removing of glioma. In this study, a fluorescent probe, Cy3, was anchored onto the terminal of AS1411, a glioma cell targeting aptamer, and then TGN, a BBB targeting peptide, was conjugated with Cy3-AS1411 through a PEG linker.

Determination of puerarin in rat plasma using PEGylated magnetic carbon nanotubes by high performance liquid chromatography.

This paper described a novel application of PEGylated magnetic carbon nanotubes as solid-phase extraction nanosorbents for the determination of puerarin in rat plasma by high performance liquid chromatography (HPLC). A solvothermal method was employed for the synthesis of monodisperse magnetites anchored onto multi-walled carbon nanotubes (MWCNTs@Fe3O4). In order to enhance the water solubility of MWCNTs@Fe3O4 that ensured sufficient contact between nanosorbents and analytes in the sampling procedure, the obtained nanomaterials were further noncovalently functionalized using a phospholipids-polyethylene glycol (DSPE-PEG).

Magnetic solid-phase extraction and determination of puerarin in rat plasma using C(18)-functionalized magnetic silica nanoparticles by high performance liquid chromatography.

In the paper, we presented a magnetic solid-phase extraction (MSPE) method based on C(18)-functionalized magnetic silica nanoparticles for the analysis of puerarin in rat plasma. The approach involves two steps including synthesis of magnetic solid-phase sorbents and bioanalysis. The synthesized magnetic silica microspheres modified with chloro(dimethyl)octylsilane (namely Fe(3)O(4)@SiO(2)-C(18)) can provide an efficient way for the extraction of puerarin through C(18) hydrophobic interaction.

Development of an on-column enrichment technique based on C18-functionalized magnetic silica nanoparticles for the determination of lidocaine in rat plasma by high performance liquid chromatography.

In this study, a novel on-column enrichment technique filled with C(18)-functionalized magnetic silica nanoparticles was successfully developed for the determination of lidocaine in rat plasma by high performance liquid chromatography (HPLC). The synthesized Fe(3)O(4)@SiO(2)-C(18) nanoparticles were locally packed into the capillary by the application of magnets. Lidocaine in the sample solutions pumped into the capillary tube could be easily adsorbed by Fe(3)O(4)@SiO(2)-C(18) through hydrophobic interaction by the interior C(18) groups, and eluted by acetonitrile solution.

Development of superparamagnetic high-magnetization C18-functionalized magnetic silica nanoparticles as sorbents for enrichment and determination of methylprednisolone in rat plasma by high performance liquid chromatography.

In this study, a novel extraction and enrichment technique based on superparamagnetic high-magnetization C(18)-functionalized magnetic silica nanoparticles (C(18)-MNPs) as sorbents was successfully developed for the determination of methylprednisolone (MP) in rat plasma by high performance liquid chromatography (HPLC). The synthesized silica-coated magnetite modified with chlorodimethyl-n-octadecylsilane was about 320 nm in diameter with strong magnetism and high surface area. It provided an efficient way for extraction and concentration of MP in the samples through hydrophobic interaction by the interior C(18) groups.