Biodegradation of short-chain phthalate esters (PAEs) by Sinomonas sp. S2 isolated from a soil contaminated by metal(loid)s smelting.

Phthalate esters (PAEs) are widely used as plasticizers and beneficiation flotation agents in ore smelters, which are ubiquitously distributed emerging contaminants in the environment. The biodegradation of PAEs by degrading microbes is a promising method for their remediation. In this study, we isolated a novel PAE-degrading bacteria, Sinomonas sp.

Traction-assisted endoscopic submucosal resection (TA-ESD) for rectal neuroendocrine tumors: a randomized multi-center trial.

Background And Aim: Endoscopic resection is the first-line choice for the treatment of rectal neuroendocrine tumors (NETs). This study aimed to compare the efficacy and safety of a modified traction-assisted endoscopic submucosal resection (TA-ESD) and traditional endoscopic submucosal resection (ESD).

Methods: In this multi-center prospective randomized controlled trial, patients with small rectal NET(< 2 cm) were 1:1 randomized into TA-ESD or traditional ESD groups.

Multi-element isotope fractionation analysis to investigate the photosensitized reactions of humic substance with 3-chloroaniline.

Dissolved organic matter including humic-like substances (HS), acting as photosensitizers participating in electron transfer reactions, can generate a variety of reactive species, such as OH radicals and excited triplet state HS (HS*) and related, which promote the degradation of organic contaminants such as 3-chloroaniline (3-CA). Multi-element-compound-specific stable isotope analysis (ME-CSIA) was applied to characterize photosensitized mechanisms employing 3-CA as a probe. HS were irradiated with artificial sunlight for elucidation of the reaction mechanisms by studying the kinetic isotope effect (H, C, N and Cl) to characterize the first irreversible bond change reaction.

Evaluating the Impact of Individualized Health Education and Cognitive Training on Clopidogrel Treatment in Elderly Stroke Patients.

Background: This study aimed to evaluate the nursing effect of individualized health education combined with cognitive training on clopidogrel treatment in elderly stroke patients.

Methods: One hundred and twelve elderly stroke patients treated in our neurology department from January to June 2019 were randomly divided into experimental and control groups. The control group received clopidogrel therapy, conventional nursing, rehabilitation exercises, and conventional health education.

MiR-203 improved renal cell injury in diabetic nephropathy by targeting SOCS6/SOCS7 and inhibiting JAK/STAT pathway activation.

This study investigates the role of miR-203 in regulating renal cell injury in diabetic nephropathy by targeting the suppressor of cytokine signaling (SOCS) proteins SOCS6 and SOCS7. Using NRK cells, we assessed apoptosis through flow cytometry and TUNEL assays, while real-time quantitative PCR (RT-PCR) quantified miRNA and mRNA expressions. Cell viability was measured using the CCK-8 assay, and cytokine levels were determined through ELISA.

P(═O)R-Directed Asymmetric Catalytic C-H Olefination Leading to C-N Axially Chiral Targets.

A novel P(═O)R-directed asymmetric catalytic olefination has been developed, enabling efficient access to carbon-nitrogen axially chiral products with excellent yields (up to 92%) and enantioselectivity (up to 99% enantiomeric excess). The synergistic coordination of phosphine oxide functionality and l-pGlu-OH with the Pd metal center, serving as an efficient directing group and chiral ligand, was key to the success of this C-H functionalization system. The reaction demonstrated a broad substrate scope, yielding 33 distinct C-N axial products.

Carbon, hydrogen, nitrogen and chlorine isotope fractionation during 3-chloroaniline transformation in aqueous environments by direct photolysis, TiO photocatalysis and hydrolysis.

This study investigates carbon, hydrogen, nitrogen and chlorine isotope fractionation during the transformation of 3-chloroaniline (3-CA) via direct photolysis, TiO photocatalytic degradation at neutral condition and hydrolysis at pH 3, pH 7 and pH 11. Direct photolysis and ∙OH reaction (UV/HO) showed similar inverse isotope fractionation (ε) for carbon (1.9 ± 0.

Association between sleep and gallstone disease in United States adults: A cross-sectional study.

Background: Both gallstone disease and sleep disorders are important public health problems. Few studies to date have investigated the associations between sleep and gallstone disease in humans. This study aimed to assess whether sleep factors (sleep time, sleep amounts, trouble sleeping) were associated with gallstone disease in the United States adults.

Carbon and hydrogen isotope fractionation of phthalates during photocatalysis reactions in aqueous solution containing Fe(III) complexes or iron minerals.

The hydrogen and carbon isotope fractionation factor (εH, εC) of dimethyl-, diethyl‑ and dibutyl phthalic acid ester during photosensitized degradation by artificial sunlight with Fe(III) ions and iron minerals (hematite, goethite and magnetite) in aqueous solution were examined by compound-specific isotope analysis (CSIA) in order to analyze the degradation mechanism. Hematite does not catalyze photosensitized degradation of phthalates. The correlation of H and C isotope fractionation (Λ = ΔδH/ΔδC) of phthalates with increasing chain length (dimethyl-; diethyl‑; and dibutyl-) were compared with values of the ∙OH radical model reaction with the aromatic ring as well as acidic and alkaline hydrolysis.

Efficacy of real-time artificial intelligence-aid endoscopic ultrasonography diagnostic system in discriminating gastrointestinal stromal tumors and leiomyomas: a multicenter diagnostic study.

Background: Gastrointestinal stromal tumors (GISTs) represent the most prevalent type of subepithelial lesions (SELs) with malignant potential. Current imaging tools struggle to differentiate GISTs from leiomyomas. This study aimed to create and assess a real-time artificial intelligence (AI) system using endoscopic ultrasonography (EUS) images to differentiate between GISTs and leiomyomas.

Causal Associations Between Gut Microbiota, Gut Microbiota-Derived Metabolites, and Alzheimer's Disease: A Multivariable Mendelian Randomization Study.

Background: Multiple studies have demonstrated that the gut microbiome is closely related to the onset of Alzheimer's disease, but the causal relationship between the gut microbiome and AD, as well as potential mediating factors, have not been fully explored.

Objective: Our aim is to validate the causal relationship between the gut microbiome and the onset of AD and determine the key mechanism by which the gut microbiome mediates AD through blood metabolites using Mendelian randomization (MR) analysis methods.

Methods: We first conducted bidirectional and mediating MR analyses using gut microbiota, blood amino acid metabolites, and AD-related single nucleotide polymorphisms as research data.

Considering the bioavailability and bioaccessibility of metal(loid)s for risk assessment of soils affected by different non-ferrous metal activities in Southwest China.

Toxic metal(loid)s released into the soil by non-ferrous metal mining and smelting activities pose a serious threat to residents and the surrounding ecosystem. Considering only total metal(loid) concentrations likely overestimates routine (eco)toxicological risk assessment of soil. We hypothesize that considering metal(loid) bioavailability/accessibility will improve the accuracy of risk assessment.

ETS translocation variant 5 (ETV5) promotes CD4 T cell-mediated intestinal inflammation and fibrosis in inflammatory bowel diseases.

E26 transformation-specific translocation variant 5 (ETV5) has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). However, the exact roles of ETV5 in regulating CD4 T cell-mediated intestinal inflammation and fibrosis formation remain unclear. Here, we reveal that ETV5 overexpression induced interleukin (IL)-9 and its transcription factor IRF4 expression in IBD CD4 T cells under T helper type 9 (Th9) cells-polarizing conditions.

Angiopoietin-like 4 (ANGPTL4) Suppression Ameliorates Lupus Nephritis in MRL/lpr Mice by Inactivating NLRP3 Inflammasome and Inhibiting Inflammatory Response.

Background: Lupus nephritis (LN) refers to the injury caused by systemic lupus erythematosus (SLE) involving the kidneys. A previous study identified angiopoietin-like protein 4 (ANGPTL4) as a novel urinary biomarker for tracking disease activity in LN.

Objective: To investigate the detailed role and regulatory mechanism of ANGPTL4 in experimental models of LN.

Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn's disease.

Background: Disrupted intestinal epithelial barrier is one of the major causes of Crohn's disease (CD). Novel molecular targets for intestinal epithelial barrier are essential to treatment of CD. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is an adhesion molecule that regulates cell adhesion, migration, and enterocyte differentiation.

Microbial metabolic activity in metal(loid)s contaminated sites impacted by different non-ferrous metal activities.

Many non-ferrous metal mining and smelting activities have caused severe metal(loid) contamination in the local soil environment. The metabolic activity of soil microorganisms in four areas affected by different metallurgical activities (production vs. waste disposal) was characterized using a contamination gradient from the contaminated site to the surrounding soils.

A vacuolar transporter plays important roles in zinc and cadmium accumulation in rice grain.

Rice grain is a poor dietary source of zinc (Zn) but the primary source of cadmium (Cd) for humans; however, the molecular mechanisms for their accumulation in rice grain remain incompletely understood. This study functionally characterized a tonoplast-localized transporter, OsMTP1. OsMTP1 was preferentially expressed in the roots, aleurone layer, and embryo of seeds.

A tale of two cities: Chinese mothers' parental burnout and parenting behaviors in Shanghai and Nanning.

Purpose: Parental burnout is a psychological syndrome that develops in response to the chronic stressors in one's role as a parent. It can be detrimental to the health and wellbeing of both parents and children and has been empirically proven to result in more negative parenting behaviours. Based on recent research, parental burnout is more prevalent in individualistic cultures.

Overexpression of RAB31 in gastric cancer is associated with released exosomes and increased tumor cell invasion and metastasis.

Background: Gastric cancer (GC) is one of most common cancers worldwide. Several studies have suggested that Rab31 functions as a membrane vesicle transport regulator; however, the mechanism by which RAB31 regulates exosome secretion and promotes metastasis remains to be clarified.

Methods: We examined the expression of RAB31 protein and mRNA in GC tissue samples via immunohistochemistry and reverse transcription-polymerase chain reaction assays, respectively.

New insights on the effect of non-ferrous metal mining and smelting activities on microbial activity characteristics and bacterial community structure.

Mining and smelting activities have brought potentially serious heavy metal(loid)s pollution to their surrounding locale. However, studies on microbial metabolic activities, community structure, and adaptation in soils proximal to non-ferrous metal mining and smelting areas are still lacking. Here the effects of biotic and abiotic characteristics of soil taken from sites surrounding inactive and active non-ferrous metal mine smelting facilities on microbial enzyme activity, microcalorimetry, and high-throughput sequencing of 16S rRNA gene barcoding were studied.

Quantifying ecological and human health risks of metal(loid)s pollution from non-ferrous metal mining and smelting activities in Southwest China.

The environmental release and transfer of heavy metal(loids) from natural and anthropogenic sources to neighboring habitats can pose an ecological threat to the exposed biota and habitat, as well as a human health risk to the residents. However, analytical tools to identify the potential contamination source(s) and assess the impact of this transfer have not been well described. Soil samples were collected from affected areas proximal to non-ferrous metal(loid)s mining and smelting facilities.

Humic Substance Photosensitized Degradation of Phthalate Esters Characterized by H and C Isotope Fractionation.

The photosensitized transformation of organic chemicals is an important degradation mechanism in natural surface waters, aerosols, and water films on surfaces. Dissolved organic matter including humic-like substances (HS), acting as photosensitizers that participate in electron transfer reactions, can generate a variety of reactive species, such as OH radicals and excited triplet-state HS (HS*), which promote the degradation of organic compounds. We use phthalate esters, which are important contaminants found in wastewaters, landfills, soils, rivers, lakes, groundwaters, and mine tailings.