Microbiome Shifts in Peri-Implantitis: Longitudinal Characterization of Dysbiosis and Resolution.

Objective: To characterize the longitudinal dynamics of the peri-implant microbiome in patients with peri-implantitis and healthy implants.

Methods: The peri-implant microbiome was characterized longitudinally in patients with peri-implantitis and healthy implants via 16S rRNA gene sequencing. Samples were collected at baseline, 3-, and 6-months post-treatment.

Computer-Assisted Implant Surgery: Implications for Teaching, Learning, and Educational Strategies.

Objective: This white paper aimed to discuss educational strategies for teaching and learning of computer-assisted implant surgery (CAIS) within the wider dental curriculum, including the pedagogy, technologies, and challenges.

Material And Methods: A review of the available literature up to February 2025 was conducted, compiling existing evidence related to the application of CAIS in dental education, both through simulation and in clinical care. The findings were further integrated with expert opinions and current best practices in dental education in a panel discussion.

Glossary of Computer-Assisted Implant Surgery and Related Terms. First Edition.

The rapid development of computer-assisted implant surgery (CAIS) and the respective research and clinical applications have necessitated a standardization of the terminology related not only to different devices, but also the different steps involved, surgical and presurgical procedures. The present glossary was introduced at the 1st International Team for Implantology Symposium on Computer-assisted Implant Surgery, based on the collective work of clinicians and researchers with deep understanding and experience in these technologies. The glossary was further refined and revised through the structured input of a large group of global experts within clinical application, research, and education of CAIS.

The clinical benefit of alveolar ridge preservation in the posterior maxilla: a systematic review and meta-analysis.

This study aimed to collectively synthesize the available evidence on the effect of alveolar ridge preservation at the posterior maxilla in reducing maxillary sinus pneumatization after tooth extraction, and the necessity of sinus floor augmentation during implant placement. Database search, along with additional screening in the grey literature were conducted, to find clinical studies where ridge preservation was performed in the posterior maxilla, and was compared with normal healing. Eleven studies were included, with 185 and 203 sites for the test and control groups, respectively.

Patient-Reported Healing of Static Computer-Assisted Sinus Lateral Window Osteotomy: A Randomized Controlled Trial.

Objective: The primary aim was to investigate differences in patient-reported healing outcomes between static computer-assisted sinus floor augmentation (SCA-SFA) and the conventional freehand approach (SFA).

Material And Methods: Patient-reported healing outcomes were recorded in visual analog scale (VAS) on days 1-7 and 14, and intra and postoperative complications were assessed on weeks 2 and 4 after surgery. Operation time and operators' assessment of efficacy for SCA-SFA utility were recorded.

Computer-Assisted Implant Surgery: Patients' Experience and Perspectives.

Objectives: Although computer-assisted implant surgery (CAIS) has increased significantly the precision of dental implant placement, documentation of the impact of such technologies in the patient-reported experience and outcomes remains, however, limited. The aim of this white paper was to assess the impact of CAIS on key aspects of the patient experience, such as its potential benefits on (1) patients' understanding and engagement with implant surgery, (2) patient's confidence with treatment outcomes, (3) patients' preferences, (4) intra- and (5) Postoperative experience and (6) long-term patient-reported outcomes and oral health-related quality of life.

Material And Methods: A review of the literature compiled existing evidence from clinical studies up to November 2024, which was later discussed and synthesized with expert opinions and the best currently documented experience and practice.

Beyond Accuracy: Clinical Outcomes of Computer Assisted Implant Surgery.

Objectives: Computer Assisted Implant Surgery (CAIS) with different technologies and modalities is becoming increasingly utilized in clinical practice. The aim of this White Paper was to synthesize evidence, reported experience, and best practices with regard to clinically relevant outcomes of static, dynamic, and robotic CAIS.

Materials And Methods: A review of the literature compiled existing evidence from clinical studies up to November 2024, which was later discussed and synthesized into clinically relevant questions with a panel of international experts.

Impact of Multimedia Information on Patients' Knowledge, Anxiety and Decision-Making Regarding Computer-Assisted and Freehand Dental Implant Surgery: A Randomised Clinical Trial.

Objective: This randomised clinical trial aimed to compare the effects of multimedia information and verbal explanations on patients' knowledge and anxiety as primary outcomes and decision-making as a secondary outcome.

Materials And Methods: One hundred patients needing dental replacement were randomly assigned (1:1) to either a multimedia group (n = 50) or a verbal group (n = 50). They completed self-administered questionnaires covering demographics, confidence with their awareness level, knowledge (score 0-5), anxiety (score 5-25) and decision-making before and after receiving either a multimedia or verbal explanation of implant surgery.

Comparison of precision of implant placement between two different guided systems for static computer-assisted implant surgery: A simulation-based experimental study.

Background/purpose: Many designs of static computer-assisted implant surgery (sCAIS) are available for clinician to achieve proper implant position. However, there were not any studies that approached the design alone to evaluate whether sleeve-in-sleeve or sleeve-on-drill design provided most accuracy implant position. The purpose of this study was to investigate the precision of implant placement with sleeve-in-sleeve and sleeve-on-drill static computer assisted implant surgery (sCAIS) designs.

Implant position accuracy using dynamic computer-assisted implant surgery (CAIS) combined with augmented reality: A randomized controlled clinical trial.

Background/purpose: Computer-assisted implant surgery (CAIS) is increasingly performed to reduce deviations in implant position. Dynamic CAIS or navigation systems provide instant display of implant drilling instruments and patient positions directly on the computer monitor. Augmented reality (AR) technology allows operators to visualize real-time information projected onto the lenses of AR glasses.

Training outcomes of novice clinicians in the use of dynamic computer assisted implant surgery: A prospective comparative study.

Background/purpose: The increasing importance of computer assisted implant surgery (CAIS) in the practice of implant dentistry calls for adequate education and training of clinicians. However, limited evidence exists to support optimal educational strategies and best practices. This study aimed to investigate the effectiveness of distributed training with dynamic CAIS (d-CAIS) on the precision of freehand implant placement by inexperienced operators.

Comparing Medium to Long-Term Esthetic, Clinical, and Patient-Reported Outcomes Between Freehand and Computer-Assisted Dental Implant Placement: A Cross-Sectional Study.

Objective: The aim of the study was to compare medium to long-term clinical and patient-reported outcomes between implants placed with computer-assisted implant surgery (CAIS) and freehand protocols.

Materials And Methods: Thirty dental implants in the anterior maxillary region with an average of 4 years after loading were assessed by means of Pink Esthetic Scores (PESs), marginal bone level (MBL), and clinical and patient-reported outcomes.

Results: CAIS significantly outperformed freehand placement with regard to PES scores (p = 0.

Dentists' Stress During the COVID-19 Pandemic: A Repeated Cross-Sectional Study.

Objectives: Although studies have revealed that dentists' mental health was initially affected by the COVID-19 pandemic, there are no reports on how this notion has evolved during the pandemic years. The aim of this study therefore was to compare Thai dentists' stress prevalence and levels due to the pandemic over a three period of the pandemic, 2020, 2021, and 2022. The associated risk and protective factors were also investigated.

Application of nanoparticles as surface modifiers of dental implants for revascularization/regeneration of bone.

Background: Osseointegrated dental implants are widely established as a first-choice treatment for the replacement of missing teeth. Clinical outcomes are however often compromised by short or longer-term biological complications and pathologies. Nanoparticle-coated materials represent a very active research area with the potential to enhance clinical outcomes and reduce complications of implant therapy.

The Accuracy of Dental Implant Placement With Different Methods of Computer-Assisted Implant Surgery: A Network Meta-Analysis of Clinical Studies.

Objective: Computer-assisted implant surgery (CAIS) has been introduced as a tool to aid in reaching a more accurate implant position. The aim of this network meta-analysis was to compare all the available CAIS techniques and obtain collective evidence on the method that offers the highest accuracy compared to freehand implant placement.

Materials And Methods: Database search was done in PubMed, Scopus, and Cochrane library in addition to extensive search in the gray literature and related systematic reviews, aiming to find clinical studies that compared any CAIS technique with another, or with freehand implant placement.

Radiographic changes after alveolar ridge preservation using autogenous raw tooth particles versus xenograft: A prospective controlled clinical trial.

Objective: The use of extracted teeth has been introduced as an option for bone grafting. However, the current method requires special machines and solutions, posing significant time and cost. The aim of this study was to evaluate the clinical performance of autogenous raw tooth particles (RTP), a grafting material made from a ground tooth using basic equipment, for alveolar ridge preservation.

Mussel shell-derived biogenic hydroxyapatite as reinforcement on chitosan-loaded gentamicin composite for antibacterial activity and bone regeneration.

In this study, hydroxyapatite (HAp) was synthesized from natural biowaste materials, specifically mussel shells, and combined with chitosan (CS) and gentamicin sulfate antibiotic (GA) using an in-situ method. The resulting composite material, designated HAp/CS-GA, has its physicochemical and structural properties characterized by Fourier transform infrared spectroscopy (FTIR) analysis. The structure was confirmed by X-ray diffraction (XRD) analysis.

Association of Peri-Implant Mucosa Dimensions With Emergence Profile Angles of the Implant Prosthesis.

Objectives: The primary aim of this cross-sectional study was to investigate the association between prosthesis design and peri-implant mucosa dimensions and morphology. The secondary aim was to investigate associations between mucosal dimensions and the presence of mucositis.

Materials And Methods: Forty-seven patients with 103 posterior bone level implants underwent clinical and radiographic examination, including cone beam computer tomography and intraoral optical scanning.

Accuracy of navigation guided implant surgery for immediate loading complete arch restorations: Prospective clinical trial.

Objectives: To assess navigation accuracy for complete-arch implant placement with immediate loading of digitally prefabricated provisional.

Materials And Methods: Consecutive edentulous and terminal dentition patients requiring at least one complete-arch FDP were treated between December 2020 and January 2022. Accuracy was evaluated by superimposing pre-operative and post-operative cone beam computed tomography (CBCT), recording linear (mm) and angular (degrees) deviations.

The use of patient-related outcomes (PRO) and experience (PRE) in assessing the periodontal and implant patient.

The purpose of this review was to summarize the evidence with regard to behavioral and psychosocial assessment of the periodontitis patient, the candidate for implant therapy, and the peri-implantitis patient. Periodontitis has an adverse effect on quality of life and its treatment can lead to significant improvements experienced by the patient. The latter is true for rehabilitation with dental implants, although patients harbor diverse expectations and perceptions of implant therapy, which can often interfere with satisfaction and/or influence long-term success.

Prosthetic design and choice of components for maintenance of optimal peri-implant health: a comprehensive review.

Current research has identified features of the prosthetic design with potential to significantly impact the long-term health of peri-implant tissues, while the choice of prosthetic components is also shown to be critical in an effort to reduce long-term complications of implant therapy. Overcontouring of the prosthesis emergence profile has been associated with marginal bone loss, recession and peri-implantitis, while the mucosal emergence angle is shown to have a strong association with peri-implant tissue inflammation. Further elements of interest include convexity/concavity of the restoration, the prosthetic connection and the different geometric configurations of junctions, as well as the peri-implant tissue dimensions.

Cyanoacrylate tissue adhesive versus silk sutures for mandibular third molar surgery: a systematic review and meta-analysis.

Objective: Cyanoacrylate tissue adhesive has been presented as an alternative to sutures and several studies have compared them. The objective of this meta-analysis was to evaluate the effect of cyanoacrylate tissue adhesive on postoperative pain and swelling, following mandibular third molar surgery.

Materials And Methods: Database search was conducted in MEDLINE/PubMed and Scopus, along with extensive search in the grey literature, including randomized and non-randomized clinical trials that applied cyanoacrylate adhesive for closing mandibular third molar surgical sites and compared it with silk sutures, assessing postoperative pain and swelling.

A Mapping Review of the Pathogenesis of Peri-Implantitis: The Biofilm-Mediated Inflammation and Bone Dysregulation (BIND) Hypothesis.

This mapping review highlights the need for a new paradigm in the understanding of peri-implantitis pathogenesis. The biofilm-mediated inflammation and bone dysregulation (BIND) hypothesis is proposed, focusing on the relationship between biofilm, inflammation, and bone biology. The close interactions between immune and bone cells are discussed, with multiple stable states likely existing between clinically observable definitions of peri-implant health and peri-implantitis.