Reframing robotics in Mohs surgery for rare cutaneous sarcomas: conceptual promise and clinical realities in precision oncology.

Dermatofibrosarcoma protuberans (DFSP) is a rare, locally aggressive cutaneous sarcoma in which achieving histologically negative margins is paramount to minimizing recurrence. Mohs micrographic surgery (MMS) has transformed margin control in DFSP by enabling sequential, layer-by-layer excision with immediate histologic assessment, yet it remains technically challenging in anatomically complex sites and in cases with ambiguous deep or subclinical peripheral spread. Recent advances in robotic microsurgical platforms-characterized by tremor elimination, high-resolution imaging, and ergonomic interfaces-offer a conceptual framework for enhancing the precision and consistency of MMS.

Ni-MOF/g-CN S-Scheme Heterojunction for Efficient Photocatalytic CO Reduction.

The rapid recombination of photoinduced charge carriers in semiconductors remains a significant challenge for their practical application in photocatalysis. This study presents the design of a step-scheme (S-scheme) heterojunction composed of carbon nitride (g-CN) and nickel-based metal-organic framework (Ni-MOF) to achieve enhanced charge separation. The establishment of an S-scheme charge transfer configuration at the interface of the Ni-MOF/g-CN heterostructure plays a pivotal role in enabling efficient charge carrier separation, and hence, high CO photoreduction efficiency with a CO evolution rate of 1014.

Functionalized carbon nanotubes interconnected with metal-organic frameworks for in-situ solar-driven evaporation and salt recovery from seawater.

Innovative solutions are needed to meet global water demand and to ensure the sustainable management of saline water resources. Indeed, solar-driven interfacial evaporation systems hold great environmental significance as they offer a sustainable and eco-friendly solution to several pressing issues. Herein, a 3D umbrella-shaped hybrid solar evaporator is innovatively developed by functionalized carbon nanotubes interlinked with metal-organic framework (MOF) nanocubes ZIF-67@CNT is sequentially anchored on cotton fabric with a centralized water supply.

Diagnostic Accuracy of Computed Tomography (CT) Coronary Angiography Compared to Invasive Coronary Angiography for Detecting Coronary Artery Disease: A Systematic Review.

Coronary artery disease (CAD) is a significant cause of morbidity and mortality worldwide, and the prevalence is continually rising. Invasive coronary angiography (ICA) has been considered the gold standard in CAD diagnosis as it offers precise information about the presence and severity of coronary artery blockages. However, computed tomography coronary angiography (CTCA) has emerged as a preferred noninvasive imaging technique from the viewpoint of patient risk because it provides high-resolution coronary images.

Interdisciplinary Hybrid Solar-Driven Evaporators: Theoretical Framework of Fundamental Mechanisms and Applications.

The global water and energy crisis seems to be mitigated with promising prospects of emerging interdisciplinary hybrid solar-driven evaporator technology (IHSE). However, the lack of numeric standards for comparison between enormously reported systems and the synergistic effects of interdisciplinary hybridization remains a significant challenge. To entice researchers from various domains to collaborate on the design of a system for realistic, large-scale applications, this study provides a comprehensive overview of the interdisciplinary approaches to IHSE from the domains of physics, chemistry, materials science, and engineering, along with their guiding principles and underlying challenges.

Peony Physiological index, interleaf microbial diversity and transcriptome response to infection stress.

Peony (Paeonia lactiflora Pall.), an important ornamental and medicinal plant, has been severely damaged by the prevalence of powdery mildew, affecting its cultivation and breeding. To ascertain the response mechanism of peony to powdery mildew infection, we examined the microbial diversity, the malondialdehyde (MDA) concentration and antioxidant enzyme activities of mild disease leaves (DL) and healthy leaves (HL) in peony, and transcriptome sequencing in DL and HL was performed.

Impact of Chronic Noise Stress on Thyroid Health: A Comparative Histomorphological and Endocrine Study in Adult Male and Female Rats.

Objective: To compare the effect of varying durations of noise exposure on the histomorphological and endocrine profile of the thyroid gland in male and female adult rats.

Study Design: An experimental study. Place and Duration of the Study: Department of Anatomy, Army Medical College, Rawalpindi / NUMS, from January to December 2020.

Ligand modelling of phytocompounds for cell wall synthesis enzyme in .

Aquaculture faces challenges from , causing Motile Aeromonas Septicaemia, particularly affecting (Rohu) in Pakistan. This study explores potential herbal antibacterials targeting , molecular docking of (ajwain) phytocompounds against pathogen. The cell wall synthesis ligase, D-alanine-D-alanine ligase (PDB ID 6ll9) was processed in BIOVIA Discovery Studio and docked with 13 antibacterial phytocompounds found after QSAR analysis of .

Non-Invasive Multi-Gas Detection Enabled by Cu-CuO/PEDOT Microneedle Sensor.

Metal-oxide-based gas sensors are extensively utilized across various domains due to their cost-effectiveness, facile fabrication, and compatibility with microelectronic technologies. The copper (Cu)-based multifunctional polymer-enhanced sensor (CuMPES) represents a notably tailored design for non-invasive environmental monitoring, particularly for detecting diverse gases with a low concentration. In this investigation, the Cu-CuO/PEDOT nanocomposite was synthesized via a straightforward chemical oxidation and vapor-phase polymerization.

Molecular insights into expression and silencing of resistance determinants in Staphylococcus aureus.

Objective: This study aimed to investigate the status of antimicrobial-resistant strains of Staphylococcus aureus in Pakistan, their association in terms of co-occurrence with the biofilm-forming genes, resistance profiling and associated discrepancies in diagnostic methods.

Methodology: A total of 384 milk samples from bovine was collected by using convenient sampling technique and were initially screened for subclinical mastitis, further preceded by isolation and confirmation of S. aureus.

Genotypic insights to Panton-Valentine leukocidin positive methicillin-resistant isolated from cattle mastitis.

In this research communication we investigate the prevalence and antimicrobial susceptibility of harboring virulent genes responsible for mastitis in cattle of Punjab, Pakistan. A total of 690 milk samples were collected from commercial dairy farms for analysis of the prevalence of subclinical and clinical mastitis and isolation of . Virulence ability and methicillin resistance in (MRSA) was determined by targeting the (the gene for Panton-Valentine leukocidin) and A genes, respectively.

Investigating seasonal air quality variations consequent to the urban vegetation in the metropolis of Faisalabad, Pakistan.

Urban atmospheric pollution is global problem and and have become increasingly critical in big cities around the world. Issue of toxic emissions has gained significant attention in the scientific community as the release of pollutants into the atmosphere rising continuously. Although, the Pakistani government has started the Pakistan Clean Air Program to control ambient air quality however, the desired air quality levels are yet to be reached.

First report on genotypic estimation of MRSA load in udder of nomadic sheep flocks affected with subclinical mastitis in Pakistan.

Mastitis is one of the highly devastating issues responsible for production and economic losses in all dairy animals including sheep. This study was designed to investigate subclinical mastitis (SCM) associated with S. aureus in lactating nomadic ewes, along with the associated risk factors analysis.

A potential mechanism of miana () and quercetin via NF-κB in infection.

Purpose: To prove the effect of Miana (M), Quercetin (Q), and the combination as an anti-inflammatory agent and Cefixime (C) as an antibiotic in Balb/c mice infected with serovar Typhi (S. Typhi) and related to the dynamics of NF-κB mRNA expression and NF-κB protein levels.

Methods: A cohort study on male Balb/c mice with subjects consisted of 8 groups with 5 each group by administration of M, Q, M + Q, M + C, Q + C, M + Q + C, C only and sterile distilled water group as negative control.

Environmental implications of phosphate-based fertilizer industrial waste and its management practices.

During the green revolution in the mid-twentieth century, the consumption of inorganic phosphorous and phosphate-based fertilizers (P-fertilizers) in the developing world skyrocketed, resulting in a proliferation of P-fertilizer industries. Phosphate-based fertilizer industries are ranked among the most environment-polluting industries. The worldwide phosphorus market, which was 68.

Circular economy and its implementation in cement industry: A case point in Pakistan.

The cement industry contributes substantially to world emissions. Sustainable and circular practices are adopted globally to mitigate such emissions. Developing countries like Pakistan lack adaptation to circular and sustainable practices.

Assessing the effects of limestone dust and lead pollution on the ecophysiology of some selected urban tree species.

Soil and air pollution caused by heavy metals and limestone dust are prevalent in urban environments and they are an alarming threat to the environment and humans. This study was designed to investigate the changes in morphological and physiological traits of three urban tree species seedlings (, and ) under the individual as well as synergetic effects of heavy metal lead (Pb) and limestone dust toxicities. The tree species were grown under controlled environmental conditions with nine treatments consisting of three levels of dust (0, 10, and 20 g) and three levels of Pb contaminated water irrigation (0, 5, and 10 mg L).

Evidence and Molecular Characterization of Multidrug Resistant Staphylococcus aureus Isolated From Equines in Pakistan.

The purpose of the current study was to investigate the nasal colonization and drug resistance profile of Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), and vancomycin-resistant S. aureus (VRSA) in donkeys (n =63), mules (n = 42), and horses (n = 98).

Differential response of nano zinc sulphate with other conventional sources of Zn in mitigating salinity stress in rice grown on saline-sodic soil.

Salinization causes the degradation of the soil and threatening the global food security but the application of essential micronutrients like zinc (Zn), improve the plant growth by stabilizing the plant cell and root development. Keeping in view the above-mentioned scenario, an experiment was conducted to compare the efficiency of conventional Zn fertilizers like zinc sulphate (ZnSO), zinc ethylene diamine tetra acetic acid (Zn-EDTA) and advance nano Zn fertilizers such as zinc sulphate nanoparticles (ZnSONPs), and zinc oxide nanoparticles (ZnONPs) (applied at the rate of 5 and 10 mg/kg) in saline-sodic soil. Results revealed that the maximum plant height (67%), spike length (72%), root length (162%), number of tillers (71%), paddy weight (100%), shoot dry weight (158%), and root dry weight (119%) was found in ZnSONPs applied at the rate of 10 mg/kg (ZnSONPs-10) as compared to salt-affected control (SAC).

The rising menace of antifungal resistance in dermatophytes among the patients of tinea capitis.

Objective: To determine the epidemiological profile of dermatophytes among patients of tinea capitis and their susceptibility pattern to fluconazole and terbinafine.

Methods: The cross-sectional study was conducted at the Department of Microbiology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, from August to December 2019, and comprised samples of hair and skin from the scalp of tinea capitis patients regardless of age and gender. Demographic details were collected and the samples were processed for direct microscopy and mycological culture.