Cefuroxime-induced toxic epidermal necrolysis in a 4-year-old male child: a case report.

Introduction: Toxic epidermal necrolysis (TEN) is a rare, life-threatening mucocutaneous reaction characterized by extensive epidermal detachment and multi-organ involvement. It is most commonly triggered by drugs, including antibiotics such as cephalosporins. Although TEN predominantly affects adults and females, its occurrence in pediatric males is exceedingly rare.

Efficacy and Safety of Tenecteplase in Acute Ischemic Stroke: A Meta-Analysis of Randomized Controlled Trials.

Introduction: Acute ischemic stroke (AIS) is the most common type of stroke, with increasing incidence and significant healthcare costs. Tenecteplase (TNK), a modified variant of tissue plasminogen activator (tPA), offers advantages such as a longer half-life and single-bolus administration. This meta-analysis evaluates the safety and efficacy of TNK compared to non-thrombolytic management in AIS to guide clinical decision-making.

Comparative Outcomes of Multiarterial Versus Single Arterial Grafting in Patients with Reduced Left Ventricular Ejection Fraction Undergoing Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis.

Ischemic cardiomyopathy with reduced left ventricular ejection fraction presents considerable outcome-related challenges, even with the development of surgical revascularization. Coronary artery bypass grafting continues to be a key therapy, yet the best grafting technique, single arterial grafting (SAG) versus multiarterial grafting (MAG) for patients with reduced EF, is uncertain. This systematic review and meta-analysis aims to assess the comparative outcomes of MAG versus SAG in this high-risk group.

Comparative efficacy and safety of no-touch versus conventional vein harvesting techniques in coronary artery bypass grafting: a systematic review and meta-analysis.

Objective: This meta-analysis aims to compare the clinical outcomes of the no-touch (NT) and conventional (CON) vein harvesting techniques in patients undergoing coronary artery bypass grafting (CABG).

Methods: We conducted a systematic review and meta-analysis following the guidelines of the Cochrane Handbook and PRISMA (Preferred Reporting Items for Systematic Review and Meta-Analysis) statement. We searched PubMed, Embase and Web of Science for randomised controlled trials (RCTs) comparing NT and CON vein harvesting techniques in CABG patients.

Extended reduced versus full-dose treatment with factor Xa inhibitors in patients with venous thromboembolism: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

Venous thromboembolism (VTE), comprising deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of cardiovascular-related death. Anticoagulation therapy is effective in preventing recurrence but poses a risk of bleeding. Reduced-dose factor Xa inhibitors (FXI) have been proposed as a long-term strategy to balance efficacy and safety.

Effect of dexamethasone and lidocaine combination on incidence of post-operative sore throat: A meta-analysis and trial sequential analysis.

Background: Postoperative sore throat (POST) is a common complication after endotracheal intubation, occurring in 30-50 % of patients. While lidocaine (local anesthetic) and dexamethasone (anti-inflammatory) are used individually to prevent POST, their combined efficacy remains unclear. This meta-analysis synthesizes evidence from randomized controlled trials to determine whether Intravenous dexamethasone-lidocaine combination is more effective than dexamethasone alone in reducing POST incidence.

Comparing mechanical thrombectomy and catheter directed thrombolysis for pulmonary embolism: A systematic review and meta-analysis.

Purpose: Pulmonary embolism (PE) is a critical condition requiring prompt intervention. Mechanical thrombectomy (MT) and catheter-directed thrombolysis (CDT) are emerging catheter-based therapies, but their comparative effectiveness remains uncertain, particularly given the predominance of observational studies.

Methods: We conducted a systematic review and meta-analysis of studies identified through PubMed, Embase, and Web of Science from inception to February 10, 2025.

Transcatheter Versus Surgical Approach for the Treatment of Aortic Stenosis in Patients With Concomitant Coronary Artery Disease: A Systematic Review and Meta-Analysis.

Aortic stenosis (AS) with concomitant coronary artery disease (CAD) requires an approach that addresses both valvular and coronary pathology. While surgical aortic valve replacement (SAVR) with coronary artery bypass graft (CABG) has long been the standard treatment, transcatheter aortic valve replacement (TAVI) with percutaneous coronary intervention (PCI) has become a less invasive alternative. This meta-analysis compares the clinical outcomes of TAVI + PCI versus SAVR + CABG in patients with AS and concomitant CAD.

Factor XIa Inhibitors Versus Direct Oral Anticoagulants for Atrial Fibrillation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

Introduction: Direct oral anticoagulants (DOACs) are the standard treatment for reducing thromboembolic risk in patients with atrial fibrillation (AF); however, bleeding remains a major concern. Factor XIa inhibitors have emerged as a potential alternative, but evidence about their therapeutic potential remains unclear. We performed a systematic review and meta-analysis to evaluate the comparative efficacy and safety of Factor XIa inhibitors versus DOACs for AF.

Efficacy and Safety of Clopidogrel Versus Aspirin Monotherapy After Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Dual antiplatelet therapy is a standard treatment after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS), but the optimal monotherapy agent post-dual antiplatelet therapy remains unclear. Clopidogrel and aspirin are widely used, yet their comparative effectiveness and safety in this patient population have not been fully established. This systematic review and meta-analysis compared the efficacy and safety of clopidogrel and aspirin monotherapy following PCI in patients with ACS.

Efficacy and Safety of Prothrombin Complex Concentrate Compared to Fresh Frozen Plasma in Cardiac Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Coagulopathy and bleeding are common complications following cardiac surgery, often requiring the use of hemostatic agents such as prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP). This systematic review and meta-analysis compared the efficacy and safety of PCC versus FFP in adult patients undergoing cardiac surgery complicated by bleeding or coagulopathy. A comprehensive search of PubMed, Embase, and Web of Science was conducted from inception to March 30, 2025, identifying randomized controlled trials comparing these interventions.

Percutaneous Mitral Valve Repair Versus Surgery in Patients With Mitral Regurgitation: A Meta-Analysis.

While studies confirm the feasibility of percutaneous mitral valve repair, its short- and long-term outcomes compared with mitral valve surgery remain debated. This meta-analysis aims to evaluate the clinical outcomes with a percutaneous approach and surgery. A comprehensive literature search of major databases that included PubMed, Embase, and the Cochrane Library was performed from inception to November 2024.

Efficacy and safety of radiofrequency ablation for hypertrophic obstructive cardiomyopathy: a meta-analysis.

Background: Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic heart disease leading to obstructive hypertrophy. Radiofrequency ablation (RFA) is a minimally invasive alternative to traditional treatments. This review evaluates RFA's effectiveness and safety for HOCM.

Exploring the interplay between anxiety and academic procrastination: An institution-based cross-sectional study from Pakistan.

Background: Procrastination, the unnecessary delay of tasks, is common among college students, especially in academic settings. Academic procrastination often leads to last-minute rushes and increased anxiety. The relationship between procrastination and anxiety is intricate, complicating the determination of which triggers the other.

Head-to-Head: Recombinant Human Prourokinase Versus Intravenous Thrombolytics in Acute Ischemic Stroke Within 4.5 Hours - A Systematic Review and Network Meta-Analysis of Randomized Clinical Trials.

BackgroundIntravenous thrombolytics are essential for achieving timely reperfusion in acute ischemic stroke (AIS), with alteplase historically serving as the standard of care. Emerging alternatives like recombinant human prourokinase (rhPro-UK), reteplase, and tenecteplase offer potential improvements in efficacy, safety, and convenience, necessitating a comparative analysis.MethodsElectronic databases, including PubMed, ScienceDirect, and Cochrane Central, were comprehensively searched from inception till December 2024 for relevant studies.

Outcomes of transcatheter vs surgical aortic valve replacement in pre-existing chronic liver disease patients: A meta-analysis of observational studies.

Aortic valve stenosis in patients with chronic liver diseases, particularly liver cirrhosis and End-Stage Liver Disease, poses significant management challenges due to the interplay between cardiovascular and hepatic dysfunction. This systematic review and meta-analysis compared the safety and efficacy of Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement in this high-risk population. An extensive search of PubMed, Embase, and Web of Science (inception to January 5, 2025) identified 11 retrospective studies comprising 19,097 patients.

Efficacy and Safety of Recombinant Human Prourokinase in Acute Ischemic Stroke Within 4.5 h: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Background: Acute ischemic stroke (AIS) requires timely thrombolysis to restore perfusion and minimize neurological damage. Recombinant human prourokinase (rhPro-UK) has emerged as a promising alternative to alteplase, with potential efficacy and safety benefits within the critical 4.5-h treatment window.

Efficacy and Safety of Distal Radial Artery Access versus Proximal Radial Artery Access for Cardiac Procedures: A Systematic Review and Meta-Analysis.

Objective: Cardiac catheterization using the distal radial artery (DRA) access, at the level of the anatomical snuff box post-radial artery bifurcation, may be linked to a lower rate of arterial occlusion and better hemostasis. In this meta-analysis, we compare DRA versus proximal radial artery (PRA) access in cardiac catheterization or angiography.

Methods: A detailed literature search was performed on PubMed, Cochrane, Embase, and Clinicaltrials.