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http://dx.doi.org/10.1097/MJT.0000000000001969 | DOI Listing |
Cureus
July 2025
Medicine and Surgery, King Edward Medical University, Lahore, PAK.
This systematic review evaluates the effectiveness and safety of adjunctive neuroprotective therapies administered in combination with reperfusion treatments, either intravenous (IV) thrombolysis, mechanical thrombectomy, or both, in adult patients with acute ischemic stroke (AIS). Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search of four major databases was conducted with filters applied to include English-language randomized controlled trials (RCTs) published within the last five years. From an initial 622 records, 10 eligible RCTs were identified and analyzed.
View Article and Find Full Text PDFAm J Ther
May 2025
Department of Medicine, Bacha Khan Medical College, Mardan, Pakistan.
Crit Care Med
April 2025
Division of Emergency Critical Care, Department of Emergency Medicine, Stony Brook University Hospital, Garden City Park, NY.
Int J Mol Sci
January 2024
Department of Anesthesiology, Stony Brook University Hospital, Stony Brook, NY 11794, USA.
Stroke is a major cause of death and disability worldwide. Endovascular thrombectomy has been impactful in decreasing mortality. However, many clinical results continue to show suboptimal functional outcomes despite high recanalization rates.
View Article and Find Full Text PDFJ Stroke
January 2023
Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Background And Purpose: Nelonemdaz (Neu2000) has both selective antagonism against 2B subunit of N-methyl-D-aspartate receptor and antioxidant activity. This drug provides sufficient evidence of neuroprotection in acute cerebral ischemia/reperfusion models. This phase III trial aims to determine this effect in patients.
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