Alginate-encapsulated ZIF-67 composite gel spheres for enhanced tetracycline removal and fixed-bed application.

The pervasive accumulation of tetracycline (TC) in aquatic ecosystems poses severe ecological and health threats, yet conventional technologies rarely achieve reliable removal under continuous-flow conditions. To overcome the intrinsic brittleness, aggregation and leaching of powdered ZIF-67, this study developed novel alginate-encapsulated MOF composite gel spheres (ALG/ZIF-67) via in-situ crystallization. This simple strategy generates hierarchical pores, anchors Co-N active sites and imparts mechanical robustness without sacrificing adsorption kinetics.

Drug resistance in breast cancer: Mechanisms and strategies for management.

Therapeutic resistance remains a significant challenge in breast cancer treatment, often driven by factors such as genetic mutations, dysregulation of receptors and signaling pathways, alterations in drug metabolism and transport, cellular heterogeneity, and modifications in the tumor microenvironment. As a highly heterogeneous and complex disease, breast cancer exhibits distinct molecular and histopathological characteristics, necessitating tailored therapeutic approaches. This article reviews recent advancements in understanding therapy resistance across four major subtypes - Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer (TNBC) - and explores potential strategies to overcome resistance, providing insights into developing novel therapeutic interventions.

Low-loss and polarization insensitive 32 × 4 optical switch for ROADM applications.

Integrated switches play a crucial role in the development of reconfigurable optical add-drop multiplexers (ROADMs) that have greater flexibility and compactness, ultimately leading to robust single-chip solutions. Despite decades of research on switches with various structures and platforms, achieving a balance between dense integration, low insertion loss (IL), and polarization-dependent loss (PDL) remains a significant challenge. In this paper, we propose and demonstrate a 32 × 4 optical switch using high-index doped silica glass (HDSG) for ROADM applications.

Pathogenesis of pulmonary hypertension caused by left heart disease.

Pulmonary hypertension has high disability and mortality rates. Among them, pulmonary hypertension caused by left heart disease (PH-LHD) is the most common type. According to the 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension, PH-LHD is classified as group 2 pulmonary hypertension.

Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4/MMP12/AKT pathway in ApoE mice fed with High-Fat-Diet.

Background: Atherosclerosis (AS) is the pathological basis of multiple cardiovascular diseases. The pathogenesis of AS is closely related to the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). Nuciferine, an aporphine alkaloid from lotus leaf, has various pharmacological activities.

Protein-enriched extracts from housefly (Musca domestica) maggots alleviates atherosclerosis in apolipoprotein E-deficient mice by promoting bile acid production and consequent cholesterol consumption.

Currently, atherosclerosis control is important to prevent future heart attacks or strokes. Protein-enriched extract (PE) from housefly maggots (Musca domestica) can inhibit the development of atherosclerosis partially through its antioxidant effects. Whether PE exerts other anti-atherosclerosis functions remains unclear.

Ecological Restoration and Carbon Sequestration Regulation of Mining Areas-A Case Study of Huangshi City.

As an important carbon sink indicator, the vegetation net primary productivity (NPP) is key and helpful for understanding regional carbon sequestration and storage of mining areas. Systematic analysis of NPP of the ecological reconstruction process in mining areas can effectively contribute to local governments and related departments for making ecological decisions under the "double carbon goals" ("peak of carbon release" and "carbon neutrality") and help to promote regional sustainable development. In this study, we used the CASA model to systematically assess the temporal and spatial evolution characteristics of NPP of Huangshi City from 1990 to 2018.

Spatial and Temporal Variations of Habitat Quality and Its Response of Landscape Dynamic in the Three Gorges Reservoir Area, China.

Habitat quality is an important indicator for assessing biodiversity and is critical to ecosystem processes. With urban development and construction in developing countries, habitat quality is increasingly influenced by landscape pattern changes. This has made habitat conservation to be an increasingly urgent issue.

Landscape Dynamics Improved Recreation Service of the Three Gorges Reservoir Area, China.

Spatio-temporal variations of recreation service not only could help to understand the impact of cultural services on human well-being but also provides theoretical and technical support for regional landscape management. However, previous studies have avoided deeply quantifying and analyzing it or have simply focused on assessing recreational service at a single period in time. In this study, we used the InVEST model to evaluate the spatio-temporal variations of recreation service in the Three Gorges Reservoir Area and demonstrated the impact of recreation service on landscape dynamics.

Mechanism and therapeutic strategies of depression after myocardial infarction.

Depression resulted as an important factor associated with the myocardial infarction (MI) prognosis. Patients with MI also have a higher risk for developing depression. Although the issue of depression after MI has become a matter of clinical concern, the molecular mechanism underlying depression after MI remains unclear, whereby several strategies suggested have not got ideal effects, such as selective serotonin reuptake inhibitors.

Plumula Nelumbinis: A review of traditional uses, phytochemistry, pharmacology, pharmacokinetics and safety.

Ethnopharmacological Relevance: Plumula Nelumbinis, the green embryo of the mature seeds of Nelumbo nucifera Gaertn, has a medical history of over 400 years. It is widely used for clearing the heart and heat, calming the mind, and promoting astringent essence and hemostasis in traditional Chinese medicine. Moreover, it usually dual use as food and medicine.

Therapeutic potential of ALKB homologs for cardiovascular disease.

Cardiovascular diseases (CVDs) are the leading causes of human death. Recently, ALKB homologs, including ALKBH1-8 and FTO, have been found to have a variety of biological functions, such as histone demethylation, RNA demethylation, and DNA demethylation. These functions may regulate the physiological and pathological processes of CVDs, including inflammation, oxidative stress, cell apoptosis, and mitochondrial, endothelial, and fat metabolism dysfunction.

Cecropin (Mdc) Alleviates -Induced Colonic Mucosal Barrier Impairment: Associating With Inflammatory and Oxidative Stress Response, Tight Junction as Well as Intestinal Flora.

, a Gram-negative food-borne pathogen, induces impairment in intestinal mucosal barrier function frequently. The injury is related to many factors such as inflammation, oxidative stress, tight junctions and flora changes in the host intestine. cecropin (Mdc), a novel antimicrobial peptide containing 40 amino acids, has potential antibacterial, anti-inflammatory, and immunological functions.

Production of bioactive liver-targeting interferon Mu-IFN-CSP by soluble prokaryotic expression.

A novel liver-targeting interferon (IFN-CSP) was successfully over-expressed in our previous work. The in vitro and in vivo investigation revealed that IFN-CSP has significant anti-hepatitis B virus (HBV) effect and liver-targeting capacity. However, due to the IFN-CSP tends to form inclusion bodies in recombinant Escherichia coli (E.