Protective Efficacy Induced by Virus-like Particles Expressing Dense Granule Protein 5 of .

() causes severe disease in immunocompromised individuals and pregnant women, underscoring the urgent need for effective vaccines against toxoplasmosis. The dense granule protein 5 (GRA5) of plays a key role in parasitic cyst formation. This study evaluated the protective immune responses induced by a virus-like particle (VLP) vaccine expressing the -derived antigen GRA5 in a mouse model challenged with the ME49 strain of .

Drug resistance in breast cancer: Mechanisms and strategies for management.

Therapeutic resistance remains a significant challenge in breast cancer treatment, often driven by factors such as genetic mutations, dysregulation of receptors and signaling pathways, alterations in drug metabolism and transport, cellular heterogeneity, and modifications in the tumor microenvironment. As a highly heterogeneous and complex disease, breast cancer exhibits distinct molecular and histopathological characteristics, necessitating tailored therapeutic approaches. This article reviews recent advancements in understanding therapy resistance across four major subtypes - Luminal A, Luminal B, HER2-enriched, and triple-negative breast cancer (TNBC) - and explores potential strategies to overcome resistance, providing insights into developing novel therapeutic interventions.

Vitamin C inhibits LPS-induced secretion of inflammatory cytokines in peripheral blood.

Despite extensive evidence demonstrating that vitamin C suppresses the secretion of inflammatory cytokines, research exploring its impact on cytokine release from peripheral blood cells upon bacterial antigen stimulation remains limited. This research investigated the influence of vitamin C on LPS-triggered secretion of cellular inflammatory cytokines in peripheral blood. Ten healthy volunteers provided heparinized whole blood, diluted with RPMI-1640 and distributed into containers.

Allyl isothiocyanate exacerbates acute toxoplasmosis through inhibition of inflammatory cytokines.

Allyl isothiocyanate (AITC) is a natural product commonly used in food preservation and pharmaceutical applications. Toxoplasmosis, caused by the protozoan pathogen Toxoplasma gondii, is prevalent globally while the impact of AITC on toxoplasmosis is unclear. We explored the effect of AITC on acute toxoplasmosis.

Bacterial pneumonia patients with elevated globulin levels did not get infected with SARS-CoV-2: two case reports.

Background: COVID-19 began in December 2019, rapidly spreading worldwide. China implemented a dynamic zero-COVID strategy and strict control measures after the outbreak. However, Guangzhou city ended closed-off management by the end of November 2022, leading to exposure to SARS-CoV-2.

Seroprevalence of Toxoplasma gondii infection among patients of a tertiary hospital in Guangzhou, Guangdong province, PR China.

Purpose: This study aimed to explore the prevalence of Toxoplasma gondii (T. gondii) among patients in Guangzhou city, South China, and to identify susceptible patient populations and analyze the causes of infection differences.

Methods: From May 2020 to May 2022, a total of 637 sera were collected from patients, and 205 sera were collected from health participants as health control.

GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma.

One of the most prevalent malignant primary brain tumors is primary glioma. Although glutathione peroxidase 8 (GPX8) is intimately associated with carcinogenesis, its function in primary gliomas has not yet been thoroughly understood. Here, we leveraged Chinese Glioma Genome Atlas (CGGA), The Cancer Genome Atlas (TCGA), and Genotype-Tissue Expression (GTEx) database to investigate the association between GPX8 and overall survival (OS) of patients with primary gliomas, and our results showed that GPX8 expression was negatively correlated with OS.

Effects of hCG on DA neuronal death of Parkinson's disease.

Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide, with the incidence in men being about twice as compared to women. Gender differences may provide clues for finding key targets that mediate the death of dopaminergic (DA) neurons in PD. Luteinizing hormone (LH), analog of human chorionic gonadotropin (hCG), and their receptor, luteinizing hormone/choriogonadotropin receptor (LHCGR), are associated with the pathogenesis of PD.