Dietary Omega-3 alleviates copper-induced nephrotoxicity via suppression of NLRP3-mediated pyroptosis and lipid metabolism disorder in chickens.

Excessive use of copper (Cu) in poultry farming induces nephrotoxicity closely related to inflammatory response and lipid metabolism disorder, but the mechanism remains unclear. Omega-3 (Ω-3), a natural polyunsaturated fatty acid with anti-inflammatory and antioxidative stress properties, has been demonstrated to exert protective effects on the kidneys. However, whether Ω-3 can alleviate Cu-induced renal injury and the underlying mechanisms remain unclear.

Isolation and characterization of a novel feline panleukopenia virus strain from Amur tigers: Insights into pathogenesis and diagnostic development.

Feline panleukopenia virus (FPV), a member of the Parvoviridae family, poses a significant threat to endangered carnivores, including the Amur tiger (Panthera tigris altaica). This study isolated a novel FPV strain (FPV-HER-NEFU) from fecal samples of infected Amur tigers and established an indirect ELISA for serodiagnosis using the recombinant non-structural protein NS1. The NS1 gene (2007 bp) was cloned into the pGEX-6P-1 vector, expressed in E.

Copper exposure elicits pyroptosis and inflammation in bursa of Fabricius and omega-3 reverses this phenomenon by inhibiting NF-κB-NLRP3-GSDMD axis: In vivo, in vitro, and in silico investigations.

The overuse of copper (Cu) in feed additives has become a major issue, disrupting animal and ecosystem balance and impairing animal immunity. Omega-3 (ω-3) PUFAs, with immunomodulatory effects, may counteract the immunotoxicity. This study, via in vivo, in vitro, and in silico methods, explored Cu exposure's impact on chicken bursa of Fabricius (BF).

Lycopene alleviates splenic injury in grass carp (Ctenopharyngodon idella) caused by endoplasmic reticulum stress-autophagy axis induced by sulfamethoxazole through regulating AKT/AMPK pathway.

Sulfamethozole (SMZ), an antibiotic widely used in aquaculture, is bioaccumulating and resistant to degradation, posing ecological risks. Although environmentally relevant SMZ concentrations (0.3 μg/L) are known to impair piscine immune function, the molecular mechanisms driving its toxicity remain elusive.

Modeling the Potential Distribution and Future Dynamics of Important Vector Under Climate Change Scenarios in China.

In the context of global warming, there is an increasing risk of the emergence and re-emergence of vector-borne diseases (VBDs). As one of the most important vectors, can carry and transmit numerous human and animal infectious pathogens. To better understand the current distribution and possible future dynamics of in China, an ecological niche modeling approach (MaxEnt) was adopted to model its current and future habitat suitability.

Lycopene regulates Nrf2 to Ameliorate Sulfamethoxazole -induced renal injury and apoptosis via inhibiting oxidative stress and Endoplasmic Reticulum stress.

The overuse and long-term existence of Sulfamethoxazole (SMZ) in aquatic system have led to adverse effects on non-target organisms, remaining a challenge for aquaculture and human health. This study investigated whether the natural carotenoid lycopene (LYC, 10 mg/kg B.W.

Unveiling the Toxic Mechanism of Arsenic on the Spleen of Cyprinus carpio and the Antagonistic Role of Zinc via the P38 MAPK/Nrf2/HO- 1 Pathway.

Arsenic (As), a prevalent heavy metal, poses significant risks to the immune systems of living organisms. The spleen is considered one of the major immune organs of As-poisoned aquatic organisms. Zinc (Zn), known for its antioxidant and detoxification properties, may alleviate As-induced immune organ damage, but the underlying mechanism remains unclear.

An in-depth analysis of the effects of excessive acetochlor exposure on chicken liver health.

Acetochlor, a commonly used herbicide, poses significant risks to ecosystem and organism health through contamination of the food chain. Despite its widespread use, there is a lack of comprehensive studies on its toxicological effects on avian species. This study investigates the impact of environmental acetochlor exposure on chicken liver health using metabolomics analysis and histopathological techniques.

GPR120 exacerbates the immune-inflammatory response in chicken liver by mediating acetochlor induced macrophage M1 polarization.

Acetochlor is a widely used and highly effective herbicide. Its overuse poses significant threats to biosecurity and ecological integrity, particularly affecting free-ranging birds. Data on its impact, especially mechanisms of liver toxicity in chickens, are lacking.

New insights into zinc alleviating renal toxicity of arsenic-exposed carp (Cyprinus carpio) through YAP-TFR/ROS signaling pathway.

Environmental pollution caused by arsenic or its compounds is called arsenic pollution. Arsenic pollution mainly comes from people mining and smelting arsenic compounds. In addition, arsenic compounds' widespread use and production of arsenic-containing pesticides, arsenic-rich water used to irrigate farms, or high arsenic levels in foods caused by coal burning are all sources of arsenic contamination.

New insights into the spleen injury by mitochondrial dysfunction of chicken under polystyrene microplastics stress.

Microplastics biological toxicity, environmental persistence and biological chemicals have been paid widespread attention. Microplastics exposed to chicken spleen injury of the specific mechanism is unclear. Thus, we randomly assigned chickens to 4 groups: C (normal diet), L-MPs (1 mg/L), M-MPs (10 mg/L), and H-MPs (100 mg/L), and assessed spleen damage after 42 d of exposure.

Assessing and mitigating foodborne acetochlor exposure induced ileum toxicity in broiler chicks: The role of omega-3 polyunsaturated fatty acids supplementation and molecular pathways analysis.

Excessive acetochlor residues present ecological and food safety challenges. Here, broiler chicks were exposed to varied acetochlor doses to first assess its effects on the gut. Subsequent dietary supplementation with omega-3 was used to assess its anti-contamination effects.

Endoplasmic reticulum stress-induced NLRP3 inflammasome activation as a novel mechanism of polystyrene microplastics (PS-MPs)-induced pulmonary inflammation in chickens.

Microplastics (MPs) have attracted growing attention worldwide as an increasingly prevalent environmental pollutant. In addition, chicken meat is currently the most widely consumed kind of poultry in the global market. Consumer demand for chicken is on the rise both at home and abroad.

Polystyrene microplastics mediate cell cycle arrest, apoptosis, and autophagy in the G2/M phase through ROS in grass carp kidney cells.

Microplastics (MPs) have attracted widespread worldwide attention as a new pollutant. However, the role of reactive oxygen species (ROS) and cell cycle in nephrotoxicity induced by different concentrations of polystyrene microplastics (PS-MPs) is unknown. This study used grass carp kidney cells (CIK) treated with different concentrations of PS-MPs (0, 0.

Perturbed Progressive Learning for Semisupervised Defect Segmentation.

Recently, with the development of intelligent manufacturing, the demand for surface defect inspection has been increasing. Deep learning has achieved promising results in defect inspection. However, due to the rareness of defect data and the difficulties of pixelwise annotation, the existing supervised defect inspection methods are too inferior to be implemented in practice.

Liver Injury Induced by Exposure to Polystyrene Microplastics Alone or in Combination with Cadmium in Mice Is Mediated by Oxidative Stress and Apoptosis.

Microplastics (MPs) have been considered an emerging environmental pollutant which, when combined with toxic metals, enter the circulatory system of mammals and eventually cause damage. Therefore, it is important to study the toxicity of the mixture of MPs and heavy metals for evaluating risk assessment of mammals. In the present study, the toxicological effects of different concentrations of polystyrene (PS)-MPs alone or in combination with cadmium chloride (CdCl) during chronic exposure (8 weeks) were evaluated using intragastric administration in mice.

Fluoride induces neutrophil extracellular traps and aggravates brain inflammation by disrupting neutrophil calcium homeostasis and causing ferroptosis.

Endemic fluorosis (EF) has been listed as one of the serious public health problems in many countries. Long-term exposure to high fluoride can lead to severe neuropathological damage to the brain. Although long-term research has revealed the mechanism of some brain inflammation caused by excessive fluoride, the role of intercellular interactions, especially immune cells, in brain damage is still unclear.

Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis.

Microplastics (MPs) are a hot environmental contaminant now. However, researchers paid little attention to their effects on immune organs such as the thymus. Here, we exposed chickens to a concentration gradient of polystyrene microplastics (PS-MPs) and then followed the decrease in the thymus index.

Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps.

Microplastics (MPs), a new and increasing environmental pollutant, can cause ongoing damage to organisms. Although recent studies have revealed mechanisms of action for some of the hepatotoxicity caused by MPs, the role-played by cellular interactions, particularly immune cells, in the process of liver injury has not been elucidated. In the present study, 5-μm polystyrene microplastics (PS-MPs) induced liver inflammation as well as the formation of Macrophage extracellular traps (METs).

Dose-effect of polystyrene microplastics on digestive toxicity in chickens (Gallus gallus): Multi-omics reveals critical role of gut-liver axis.

Introduction: Microplastic pollution seriously threatens the health and safety of humans and wildlife. Avian is one of the main species endangered by microplastics. However, the damage mechanism of microplastics to the digestive system of avian is not clear.

Polystyrene microplastics induce autophagy and apoptosis in birds lungs via PTEN/PI3K/AKT/mTOR.

Microplastics (MPs) seriously pollute and potentially threaten human health. Birds are sentinels of environmental pollutants, which respond quickly to contamination events and reveal current environmental exposure. Therefore, birds are good bioindicators for monitoring environmental pollutants.