circRNADisease v2.0: an updated resource for high-quality experimentally supported circRNA-disease associations.

circRNADisease v2.0 is an enhanced and reliable database that offers experimentally verified relationships between circular RNAs (circRNAs) and various diseases. It is accessible at http://cgga.

Lyoniresinol attenuates cerebral ischemic stroke injury in MCAO rat based on oxidative stress suppression via regulation of Akt/GSK-3β/Nrf2 signaling.

Stroke is one of the predominant causes of death and disability. Currently, besides thrombolytic therapy, neuroprotection is also generally recognized as a promising way for stroke treatment, which would be very important for the functional recovery of stroke patients. However, it's reported that all the current available neuroprotective drugs have failed in clinical investigations of stroke treatments so far.

singleCellBase: a high-quality manually curated database of cell markers for single cell annotation across multiple species.

Annotating cells in the analysis of single-cell RNA-seq (scRNA-seq) data is one of the most challenging tasks that researchers are actively addressing. Manual cell annotation is generally considered the gold standard method, although it is labor intensive and independent of prior knowledge. At present, the relationship between high-quality, known marker genes and cell types is very limited, especially for a variety of species other than humans and mice.

Conjugation-regulating synthesis of high photosensitizing activity porphyrin-based covalent organic frameworks for photodynamic inactivation of bacteria.

Preparation of porphyrin-based covalent organic frameworks (Por-COFs) with high photosensitizing activity for photodynamic inactivation of bacteria is of great challenge, but significant for economy and human health. Herein, we show a conjugation-regulating strategy to design and synthesize Por-COFs with high photosensitizing activity for the photodynamic inactivation of bacteria. Terephthalaldehyde (Da), 2,5-Dihydroxyterephthalaldehyde (Dha), and 2,5-Diethoxyterephthalaldehyde (Deta) with different conjugation degrees are selected to condense with 5,10,15,20-Tetrakis(4-aminophenyl)porphyrin (Tph) to synthesize COF-366, DhaTph, and JNU-2, respectively.

OncoPDSS: an evidence-based clinical decision support system for oncology pharmacotherapy at the individual level.

Background: Precision oncology pharmacotherapy relies on precise patient-specific alterations that impact drug responses. Due to rapid advances in clinical tumor sequencing, an urgent need exists for a clinical support tool that automatically interprets sequencing results based on a structured knowledge base of alteration events associated with clinical implications.

Results: Here, we introduced the Oncology Pharmacotherapy Decision Support System (OncoPDSS), a web server that systematically annotates the effects of alterations on drug responses.

Irreversible Amide-Linked Covalent Organic Framework for Selective and Ultrafast Gold Recovery.

Design of stable adsorbents for selective gold recovery with large capacity and fast adsorption kinetics is of great challenge, but significant for the economy and the environment. Herein, we show the design and preparation of an irreversible amide-linked covalent organic framework (COF) JNU-1 via a building block exchange strategy for efficient recovery of gold. JNU-1 was synthesized through the exchange of 4,4'-biphenyldicarboxaldehyde (BA) in mother COF TzBA consisting of 4,4',4''-(1,3,5-triazine-2,4,6-triyl)trianiline (Tz) and BA with terephthaloyl chloride.

[Aerosol Chemical Characteristics for Different Air Pollution Levels in North Suburban Nanjing].

PMsamples were collected in a northern suburb of Nanjing during the winter of 2015. Water soluble ions and carbonaceous substances under different air quality levels were analyzed by an 850 professional IC-type ion chromatograph produced by Metrohm and a Model 2001A carbon analyzer. The results show that the average mass concentration of PM, SO, NO, and NH during heavy pollution days was 4.

[Hydraulic simulation and safety assessment of secondary water supply system with anti-negative pressure facility].

In the last few decades, anti-negative pressure facility (ANPF) has been emerged as a revolutionary approach for sloving the pollution in the Second Water Supply System (SWSS) in China. This study analyzed implications of the safety in SWSS with ANPF, utilizing the water distribution network hydraulic model. A method of hydraulic simulation and security assessment was presented which was able to reflect the number and location of nodes that can be installed in ANPF.

[Flaw of demand coverage based method for optimal locations of monitoring stations and modification].

The method of locating online sensor on a water distribution system for monitoring water quality was investigated. A flaw of demand coverage method was identified. To overcome this flaw, a demand coverage index based method was proposed in this paper.

[Reliable efficacy of vardenafil for treatment of erectile dysfunction].

Reliable efficacy is very important to continuing treatment for patients with erectile dysfunction. Vardenafil is a potent, highly selective phosphodiesterase 5 (PDE5) inhibitor. The efficacy and safety of vardenafil has been confirmed in many clinical studies.