Integrated transcriptomic and metabolomic analysis of the antibacterial mechanism of Rhizoma Coptidis extract against Staphylococcus epidermidis ATCC 35984.

Background: Biofilm formation is a key virulence factor in Staphylococcus epidermidis. Rhizoma Coptidis, the medicinal root of Coptis chinensis, has been traditionally used in Chinese medicine for its broad-spectrum antimicrobial properties.

Results: This study investigated the antibacterial and anti-biofilm effects of Rhizoma Coptidis extract against S.

Transcriptomic and metabolomic analyses of the antimicrobial activity of phenoxyethanol against phylotype IA1 and II Cutibacterium acnes.

Aims: Phenoxyethanol is a broad-spectrum antimicrobial agent widely used in cosmetic formulations. However, its antibacterial effects on different skin bacteria, particularly the predominant Cutibacterium acnes and its various phylotypes, remain unclear. The objective of this study was to examine the antimicrobial effects of phenoxyethanol on C.

MGDDI: A multi-scale graph neural networks for drug-drug interaction prediction.

Drug-drug interaction (DDI) prediction is crucial for identifying interactions within drug combinations, especially adverse effects due to physicochemical incompatibility. While current methods have made strides in predicting adverse drug interactions, limitations persist. Most methods rely on handcrafted features, restricting their applicability.

KRAS is a prognostic biomarker associated with diagnosis and treatment in multiple cancers.

encodes K-Ras proteins, which take part in the MAPK pathway. The expression level of KRAS is high in tumor patients. Our study compared expression levels between 33 kinds of tumor tissues.

iEnhancer-MRBF: Identifying enhancers and their strength with a multiple Laplacian-regularized radial basis function network.

An enhancer is a short DNA sequence containing many binding sites of transcription factors that plays a crucial role in the gene expression of major eukaryotes. It is difficult to avoid the time consumption and high cost of experimental methods. Therefore, with the continuous development of genomics, it is an urgent task to identify enhancers and their intensities by computational methods.

[Case-control study on cancellous screw and compression bolt in the treatment of calcaneal fractures wih minimally invasive plate].

Objective: To evaluate percutaneous reduction by Kirschner pin and internal fixation with cancellous screw and plate through minimal incision at the lateral side of heel for the treatment of intra-articular displacement fracture of calcaneus.

Methods: From September 2009 to June 2012, 80 patients with close intra-articular displacement fractures of calcaneus were divided into treatment group and control group. There were 40 patients in the control group, including 21 males and 19 females, ranging in age from 23 to 64 years old, averaged (39.