Feasibility and Outcomes of Vessel-Sparing Surgery for Soft Tissue Sarcoma of the Thigh Adjacent to Femoral Vessels.

Objective: This study aims to investigate the feasibility and oncological outcomes of vessel-sparing surgery for soft tissue sarcomas located near the femoral vessels in the thigh. A comparison was made with cases where the tumor was not adjacent to the femoral vessels, focusing on recurrence rates, survival prognosis, and the viability of vessel-sparing surgical techniques.

Methods: A retrospective analysis was conducted on 211 cases.

Parental influence on Chinese childhood cancer survivors' physical activity: a mixed methods study.

Parents influence the physical activity (PA) of the childhood cancer survivors (CCS). This mixed-methods study, aiming to obtain an understanding of Chinese parents' perceptions of PA in CCS and how the cancer experience changes their views, which may affect these children's PA engagement. A mixed methods study was conducted at two hospitals in Hangzhou.

Applied theory of planned behavior to explore associated factor of physical activity level among Chinese childhood cancer survivors.

Objective: Low physical activity (PA) levels are common among childhood cancer survivors (CCS) and have a serious negative impact on their physical recovery and long-term health. This study aimed to explore the factors that contribute to low levels of PA from the perspective of children themselves and how these factors affect their PA.

Methods: In this cross-sectional survey, CCS were recruited by purposive sampling from several children's medical centers nationwide.

The impact of dynamic linking on cooperation on complex networks.

In complex social systems, individual relationships and the surrounding environment are constantly changing, allowing individuals to interact on dynamic networks. This study aims to investigate how individuals in a dynamic network engaged in a prisoner's dilemma game adapt their competitive environment through random edge breaks and reconnections when faced with incomplete information and adverse local conditions, thereby influencing the evolution of cooperative behavior. We find that random edge breaks and reconnections in dynamic networks can disrupt cooperative clusters, significantly hindering the development of cooperation.

mTORC1 accelerates osteosarcoma progression via mA-dependent stabilization of USP7 mRNA.

Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progression remained to be elucidated.

The regulation of N6-methyladenosine modification in PD-L1-induced anti-tumor immunity.

There is growing evidence that programmed death ligand-1 (PD-L1) has exciting therapeutic efficacy in hematological malignancy and partial solid tumors. However, many patients still face failure with the treatment of immune checkpoint blockade because of PD-L1 expression regulation during transcription and post-transcription processes, including N6-methyladenosine (m6A). Similar to the epigenetic regulation in DNA and histones, recent research has revealed the essential regulation of m6A modification in RNA nuclear export, metabolism and translation.

Associated factors on physical activity among childhood cancer survivors in Mainland China: a qualitative exploration applied health belief model.

Purpose: Regular physical activity (PA) is essential for childhood cancer survivors (CCS), yet most CCS have difficulty participating in it. The level of PA participation among CCS in China is lower than those of western countries, leading to a worse long-term survival of CCS in China. Here, the study aims to explore the associated factors on the PA performance among CCS.

Minimum distance quantile regression for spatial autoregressive panel data models with fixed effects.

This paper considers the quantile regression model with individual fixed effects for spatial panel data. Efficient minimum distance quantile regression estimators based on instrumental variable (IV) method are proposed for parameter estimation. The proposed estimator is computational fast compared with the IV-FEQR estimator proposed by Dai et al.

Estrogen/ER in anti-tumor immunity regulation to tumor cell and tumor microenvironment.

As the essential sexual hormone, estrogen and its receptor has been proved to participate in the regulation of autoimmunity diseases and anti-tumor immunity. The adjustment of tumor immunity is related to the interaction between cancer cells, immune cells and tumor microenvironment, all of which is considered as the potential target in estrogen-induced immune system regulation. However, the specific mechanism of estrogen-induced immunity is poorly understood.

Perioperative mortality of metastatic spinal disease with unknown primary: A case report and review of literature.

Background: Spinal metastases are common in patients with malignancies, but studies on those metastasized from unknown primaries are scarce due to the difficulty in treatment and the relatively poor prognosis. Knowledge of surgical complications, particularly perioperative mortality, in patients with spinal metastases from unidentified sources is still insufficient.

Case Summary: A 54-year-old man with chest-back pain was diagnosed with spinal metastasis in the seventh thoracic vertebra (T7).

Different roles of matrix metalloproteinase 2 in osteolysis of skeletal dysplasia and bone metastasis (Review).

Matrix metalloproteinase 2 (MMP2) is a well‑characterized protein that is indispensable for extracellular matrix remodeling and other pathological processes, such as tumor progression and skeletal dysplasia. Excessive activation of MMP2 promotes osteolytic metastasis and bone destruction in late‑stage cancers, while its loss‑of‑function mutations result in the decreased bone mineralization and generalized osteolysis occurring progressively in skeletal developmental disorders, particularly in multicentric osteolysis, nodulosis and arthropathy (MONA). Either upregulation or downregulation of MMP2 activity can result in the same osteolytic effects.

Prognostic factors of patients with extremity myxoid liposarcomas after surgery.

Background: Extremity myxoid liposarcoma (MLS) is a rare soft tissue sarcoma in adults. We performed this study to define distinctive clinical features of extremity MLS by assessing prognostic factors.

Methods: Between 1973 and 2015, 1756 patients with extremity MLS who underwent surgical resection were retrieved from the Surveillance, Epidemiology, and End Results (SEER) database of the US National Cancer Institute.

Autophagy inhibitor enhance ZnPc/BSA nanoparticle induced photodynamic therapy by suppressing PD-L1 expression in osteosarcoma immunotherapy.

Elevated expression of programmed death ligand-1 (PD-L1) on the surface of tumor cells can exhaust cytotoxic T lymphocyte cells and lead to the failure of anti-tumor immunity during the course of tumor treatment. Here, we implemented a combined regimen of tumor resection and bovine serum albumin-Zinc phthalocyanine-induced photodynamic therapy (PDT). To overcome the long-distance metastasis of osteosarcoma, we also explored the effects of PD-L1 down-regulation with PDT and the autophagy inhibitor 3-MA on osteosarcoma treatment.

Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases.

This study was performed to explore the clinical efficacy of bone transport using external fixation for treatment of large bone defects after tibial tumor resection in five patients. Bone transport started 14 days postoperatively at 1 mm/day and was adjusted according to the callus-to-diameter ratio. The bone transport time, bone graft fusion, relapse, and metastasis were recorded.

Paeoniflorin induces G2/M cell cycle arrest and caspase-dependent apoptosis through the upregulation of Bcl-2 X-associated protein and downregulation of B-cell lymphoma 2 in human osteosarcoma cells.

Paeoniflorin (PF), extracted from the peony root, has been proved to possess antineoplastic activity in different cancer cell lines. However, it remains unclear whether PF has an antineoplastic effect against osteosarcoma cells. The present study investigated the effects and the specific mechanism of PF on various human osteosarcoma cell lines.

Estrogen receptor β exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-kB/BCL-2 and PI3K/Akt signal pathway.

This study aimed to investigate the effects of Estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms involved in this process. Osteosarcoma U2-OS cells consisted four groups, and treated by E2, E2 + LY294002 (ERβ agonists), E2 + ERβ siRNA, E2 + ERβ siRNA + LY294002, respectively. Cell counting kit 8 (CCK-8) assay was performed to detect the cell viability of U2-OS cells in each group.

Licochalcone A Inhibits MMPs and ADAMTSs via the NF-κB and Wnt/β-Catenin Signaling Pathways in Rat Chondrocytes.

Background: Osteoarthritis (OA) is a joint disease in which cartilage degradation is the central pathological change. In this study, we investigated the anti-osteoarthritic effects of licochalcone A (Lico A) in rat chondrocytes.

Methods: Polymerase chain reaction and Western blotting were performed to evaluate the expression of a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-5, ADAMTS-4, collagen II, matrix metalloproteinase (MMP)-13 and MMP-1 at both the gene and protein levels, respectively.

Reconstruction of large tibial bone defects following osteosarcoma resection using bone transport distraction: A report of two cases.

The clinical efficiency of bone transport distraction osteogenesis in the reconstruction of large tibial defects following resection of osteosarcoma remains unclear. The current study presents two cases of large tibial defects treated with bone transport distraction using an Orthofix external fixator. Case 1 was a 29-year-old man with a tibial defect 11 cm in length, while case 2 was a 16-year-old girl with a 15-cm-long defect.

Effects of shading on spike differentiation and grain yield formation of summer maize in the field.

A field experiment was conducted to study the effects of shading on tassel and ear development and yield formation of three summer maize hybrids Zhenjie 2 (ZJ2), Denghai 605 (DH605), and Zhengdan 958 (ZD958). The ambient sunlight treatment was used as control (CK) and shading treatments (40 % of ambient sunlight) were applied at different growth stages from silking stage (R1) to physiological maturity stage (R6) (treatment S1), from the sixth extended leaf stage (V6) to R1 (treatment S2) and from seeding to R6 (treatment S3). Shading had no significant effect on the time from seeding to shoot emergence (VE); however, subsequent growth and development were delayed with shading beyond this point.

[Effects of shading on endogenous hormones regulation in kernel development of summer maize in the field].

Taking 3 maize hybrids, Zhenjie 2 (ZJ2), Denghai 605 (DH605) and Zhengdan 958 (ZD958) as test materials, the effects of shading on the physiological function of endogenous hormones during grain formation of summer maize were investigated in the field. The ambient sunshine treatment was used as the control (CK) and 3 shading treatments with a shading degree of 60% were designed in growth periods ranging from tasseling to maturity (S1), from jointing to tasseling stage (S2) and whole growing period (S3), respectively. Results showed that the total floret number, filament number and pollination floret number decreased after shading in comparison with CK, and aborted seeds increased accordingly.

[Effects of shading on dry matter accumulation and nutrient absorption of summer maize].

Taking summer maize cultivars Zhenjie 2 (ZJ2), Denghai 605 (DH605), and Zhengdan 958 (ZD958) as test materials, a field trial was conducted to study the effects of shading on the dry matter accumulation and nitrogen (N), phosphorus (P) and potassium (K) absorption of summer maize. Four treatments were installed, i. e.

Anterior dislocation of the sacroiliac joint with complex fractures of the pelvis and femur in children: a case report.

Pediatric sacroiliac joint injuries are uncommon lesions, especially when combined with anterior sacroiliac dislocation. Here, we present a rare case of anterior dislocation of the sacroiliac joint associated with ipsilateral acetabulum, subtrochanteric, and pubic rami fractures combined with a contralateral sacral fracture. This appears to be the first such case reported in the literature.

Total hip arthroplasty with cementless cups and femoral head autografts for patients with hip dysplasia and osteoarthritis.

Objective: To evaluate the outcome of total hip arthroplasty (THA) with cementless cups and femoral head autografts for patients with hip dysplasia and osteoarthritis.

Methods: Between 1995 and 2002, we implanted 23 cementless cups and femoral head autografts in 20 patients with hip dysplasia and osteoarthritis. In this study, a retrospective study was made on 21 hips in 20 patients (18 females and 2 males, aged 50 years on an average) with developmental hip dysplasia treated by THA with a cementless cup and femoral head autograft.