Advances in immuno-based and targeted therapies in extensive-stage small cell lung cancer.

Immunotherapy now plays a key role in supplementing and even replacing conventional agents in tumor treatment. Immune checkpoint inhibitors (ICIs), represented by atezolizumab and durvalumab, have shown encouraging therapeutic effects in the combination chemotherapy for extensive-stage small cell lung cancer (SCLC) and have become preferred regimens. It has marked a seminal shift in the treatment landscape with achieving for the first time that overall survival exceed 1 year.

Global trends and hotspots in the learning curves of robotic-assisted surgery: a bibliometric and visualization analysis.

In recent years, there has been a substantial increase in the number of research papers published in the field of robotic-assisted surgery (RAS). Nevertheless, systematic analyses focusing on the key hotspots associated with the learning curves (LCs) of RAS, global collaboration models, and future trends remain relatively limited. This study employed bibliometric methods to conduct a comprehensive search and analysis of papers on the LC of RAS published in the Web of Science Core Collection between 2005 and 2025.

Development and validation of a risk prediction model for tigecycline-induced hypofibrinogenemia in septic patients: a retrospective cohort study.

Background: Tigecycline is widely used in China to treat multidrug-resistant bacterial infections, with hypofibrinogenemia being the most common adverse effect due to its impact on coagulation. Although a predictive model for tigecycline-induced hypofibrinogenemia has been developed, it lacks external validation. This study aims to construct a predictive model for the risk of tigecycline-induced hypofibrinogenemia in sepsis patients.

The impact of rs4698412 variant on Parkinson's disease progression in a longitudinal study.

Background: While the rs4698412 variant demonstrates a robust association with Parkinson's disease (PD) susceptibility, its role in modulating PD progression remains unexplored.

Objectives: To evaluate differences in the progression of motor symptoms and cognitive function between PD patients carrying the rs4698412 A-allele variant and GG homozygotes.

Methods: Baseline clinical data were collected during their initial visits.

Impact of a visual mobile terminal-based continuity of care model on caregiver competence of children with enterostomies.

Background: Children with critical acute abdominal conditions often undergo intestinal stoma surgery.

Aim: To explore the impact of a visual mobile terminal-based extended care model on caregiver competence for children with enterostomies.

Methods: One hundred twenty children with enterostomies and their caregivers in a children's hospital in Beijing were divided into a control group and a study group.

Shenlian Extract Protects against Ultrafine Particulate Matter-Aggravated Myocardial Ischemic Injury by Inhibiting Inflammation and Cell Apoptosis.

Objective: Emerging evidence suggests that exposure to ultrafine particulate matter (UPM, aerodynamic diameter < 0.1 µm) is associated with adverse cardiovascular events. Previous studies have found that Shenlian (SL) extract possesses anti-inflammatory and antiapoptotic properties and has a promising protective effect at all stages of the atherosclerotic disease process.

Carbon Flow in Acidic CO Electroreduction.

Electrochemical CO reduction in acidic media attracts extensive research attention due to its potential in increasing carbon efficiency. In most reports, alkali cations are introduced to suppress hydrogen evolution and to promote CO reduction. However, the mass transport of alkali cations through cation exchange membrane induces the change of electrolyte compositions.

The token undermining effect: When and why adding a small reward to a dated outcome makes it less preferred.

The mere token strategy, which adds a small reward (token) to an option to increase attractiveness, is widely used in the consumer field. However, we conducted six studies that seek to confirm the 'token undermining effect', where adding a small token to a sooner and smaller reward (SS) paired with a later and larger reward (LL) decreases the preference for the SS. The results showed that the effect persists across various choice sets, participant populations, reward amounts, delays, outcome properties and regardless of whether the scenarios are incentivized.

Screening and verification of differentially expressed serum proteins in children with severe adenovirus pneumonia.

Background: Human adenoviruses are prevalent pathogens that cause severe acute respiratory infections. The clinical presentation of the adenoviral pneumonia is varied; in severe cases, they may cause systemic multi-system damages. Currently, early clinical differential diagnosis is difficult under the existing testing methods, the study identified potential biomarkers by screening and validating differentially expressed proteins (DEPs), and aimed at distinguishing between severe and non-severe adenovirus pneumonia in children aged <14 years.

Interaction Between Genetic Susceptibility and COVID-19 Pathogenesis in Pediatric Multisystem Inflammatory Disorders: The Role of Immune Responses.

Numerous studies have highlighted the emergence of coronavirus disease (COVID-19) symptoms reminiscent of Kawasaki disease in children, including fever, heightened multisystem inflammation, and multiorgan involvement, posing a life-threatening complication. Consequently, extensive research endeavors in pediatric have aimed to elucidate the intricate relationship between COVID-19 infection and the immune system. COVID-19 profoundly impacts immune cells, culminating in a cytokine storm that particularly inflicts damage on the pulmonary system.

Exploring myometrial microenvironment changes at the single-cell level from nonpregnant to term pregnant states.

The microenvironment and cell populations within the myometrium play crucial roles in maintaining uterine structural integrity and protecting the fetus during pregnancy. However, the specific changes occurring at the single-cell level in the human myometrium between nonpregnant (NP) and term pregnant (TP) states remain unexplored. In this study, we used single-cell RNA sequencing (scRNA-Seq) and spatial transcriptomics (ST) to construct a transcriptomic atlas of individual cells in the myometrium of NP and TP women.

[Cardiovascular complications in malaria: a review].

Malaria, one of the major global public health events, is a leading cause of mortality and morbidity among children and adults in tropical and subtropical regions(mainly in sub-Saharan Africa), threatening human health. It is well known that malaria can cause various complications including anemia, blackwater fever, cerebral malaria, and kidney damage. Conventionally, cardiac involvement has not been listed as a common reason affecting morbidity and mortality of malaria, which may be related to ignored cases or insufficient diagnosis.

Photocatalytic Intramolecular Alkene Hydroamination of -Alkoxy Ureas: An Approach to Imidazolinones.

Imidazolinones were obtained in good yields by intramolecular hydroamination of -alkoxy ureas in the presence of an organic photocatalyst and an inorganic base. In this reaction, the -alkoxy urea anion generated by deprotonation undergoes photocatalyzed single-electron-transfer oxidation to generate the corresponding radical, which cyclizes to afford the imidazolinone ring. This new protocol grants access to an array of complex molecules containing a privileged imidazolinone core.

Impacts of air pollution and meteorological conditions on dry eye disease among residents in a northeastern Chinese metropolis: a six-year crossover study in a cold region.

The purpose of this study is to explore the associations among dry eye disease (DED), air pollution, and meteorological conditions in the cold region of a northeastern Chinese metropolis (i.e., Changchun).

gene mutation causing familial Silver-Russell syndrome: A case report and review of literature.

Background: Cyclin-dependent kinase inhibitor 1C () is a cell proliferation inhibitor that regulates the cell cycle and cell growth through G1 cell cycle arrest. mutations can lead to IMAGe syndrome ( allele gain-of-function mutations lead to intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenital, and genitourinary malformations). We present a Silver-Russell syndrome (SRS) pedigree that was due to a missense mutation affecting the same amino acid position, 279, in the gene, resulting in the amino acid substitution p.

Molecular epidemiology analysis of symptomatic and asymptomatic norovirus infections in Chinese infants.

Background: Norovirus is a leading cause of acute gastroenteritis among children. Previous studies based on symptomatic infections indicated that mutations, rather than recombination drove the evolution of the norovirus ORF2. These characteristics were found in hospital-based symptomatic infections, whereas, asymptomatic infections are frequent and contribute significantly to transmission.

[Pharmacodynamic substances and therapeutic potential of Wuji Pills:based on UPLC-Q-TOF-MS/MS and network pharmacology].

As a classic prescription, Wuji Pills is composed of Coptidis Rhizoma, Euodiae Fructus Preparata, and stir-fried Paeo-niae Radix Alba at the ratio of 6∶1∶6. The practical application of it is limited compared with other famous Chinese medicine prescriptions. Only one company produces Wuji Pills in China.

Heat shock protein 40 of Streptococcus pneumoniae induces immune response of human dendritic cells via TLR4-dependent p38 MAPK and JNK signaling pathways.

Introduction: Heat shock protein 40 (HSP40) is a vaccine adjuvant candidate for Streptococcus pneumoniae. The mechanism by which HSP40 activates the human dendritic cells (DCs) is unclear.

Methods: DCs were isolated from human peripheral blood and their markers (HLA-DR, CD86, CD83, and CD80) were detected by flow cytometry.

A 7-year-old boy with recurrent cyanosis and tachypnea: A case report.

Background: Brain tumors are the most common solid tumors in children and comprise 25% of all malignancies in children. Common presentations include headache, nausea and vomiting, gait abnormality, papilledema, and epileptic seizure; however, some symptoms can be very insidious, with atypical and misleading manifestations.

Case Summary: Here, we report a 7-year-old boy who presented with recurrent cyanosis and tachypnea after exercise for 2 years.

Rejection of Acellular Porcine Corneal Stroma Transplantation During Coronavirus Disease 2019 Pandemic.

To report 2 successfully managed cases of graft rejection with acellular porcine corneal stroma (APCS) transplantation in patients with fungal corneal ulcer. Two patients were diagnosed with fungal corneal ulcer and received APCS transplantation. Graft rejection developed due to the lost follow-up during the period of coronavirus disease 2019 outbreak.

Identification and functional analysis of novel variants in Chinese patients with Coffin-Siris syndrome 9.

SOX11 is a transcription factor belonging to the sex determining region Y-related high-mobility group box family that plays a vital role in early embryogenesis and neurogenesis. variants in have been initially reported to cause a rare neurodevelopmental disorder, mainly referred to Coffin-siris syndrome 9 (CSS9, OMIM# 615866) which is characterized with growth deficiency, intellectual disability (ID), microcephaly, coarse facies, and hypoplastic nails of the fifth fingers and/or toes. A recent large-scale cohort study suggests that variation would result in a clinically and molecularly distinct disease from CSS.

Damage of brown planthopper (BPH) and rice leaf folder (LF) in parent plants lead to distinct resistance in ratoon rice.

Herbivore-induced defense responses are often specific, whereas plants could induce distinct defense responses corresponding to infestation by different herbivorous insects. Brown plant hopper (BPH) , a phloem-feeding insect, and rice leaf folder (LF) , a chewing insect, are both specialist herbivores on rice. To characterize the distinct resistance primed by prior damage to these two specialist herbivores, we challenged rice plants with two herbivores during vegetative growth of parent plants and assessed plant resistance in subsequent ratoons.

Pulmonary lymphomatoid granulomatosis in a 4-year-old girl: A case report.

Background: Pulmonary lymphomatoid granulomatosis (PLG) is a lymphoproliferative disease associated with Epstein-Barr viral infection occurring mainly in adults and rarely in children. It is characterized by multiple pulmonary nodules. Its diagnosis depends on lung biopsy findings.