Erratum: [Corrigendum] LSKL peptide alleviates subarachnoid fibrosis and hydrocephalus by inhibiting TSP1-mediated TGF-β1 signaling activity following subarachnoid hemorrhage in rats.

[This corrects the article DOI: 10.3892/etm.2016.

Relationship between baseline platelet-to-red blood cell distribution width ratio and all-cause mortality in non-traumatic subarachnoid hemorrhage: A retrospective analysis of the MIMIC-IV database.

Objective: The study aimed to evaluate the relationship between baseline platelet-to-red blood cell distribution width ratio (PRR) and mortality in critically ill patients with non-traumatic subarachnoid hemorrhage (SAH).

Methods: This cohort study of adults with non-traumatic SAH used Medical Information Mart for Intensive Care (MIMIC-IV) data from 2008-2022 admissions at the Intensive Care Unit (ICU). We collected the PRR levels at admission and determined the all-cause death rates for the ICU and hospital.

Development and validation of a predictive model for ventilator-associated pneumonia in patients with cardiogenic shock: based on the MIMIC-IV database.

Background: Mechanical ventilation is crucial for patients with cardiogenic shock (CS), while diagnosing ventilator-associated pneumonia (VAP) in CS patients is difficult. Therefore, there is an urgent need for an effective diagnostic model for VAP in CS. This study aims to develop an effective risk prediction model for VAP in CS patients based on clinical data.

Accuracy and acceptability of self-sampling HPV testing in cervical cancer screening: a population-based study in rural Yunnan, China.

To evaluate the accuracy and acceptability of self-sampling samples for HPV testing for cervical cancer screening in rural Yunnan of China. In 2022, 3000 women aged 17-69 were recruited and provided self-sampling vaginal samples alongside provider-sampling samples for HPV DNA and E6/E7 mRNA testing, as well as artificial intelligence (AI)-assisted cytology. Women who tested positive for any high-risk HPV DNA or mRNA, or who displayed cytology abnormalities, were recalled for a colposcopy examination and biopsied when necessary.

[Protective effect of Formula against cigarette smoke extract-induced human bronchial epithelial cell damage and its mechanism].

Objectives: To evaluate the protective effect of Formula (BYF) against cigarette smoke extract (CSE)-induced injuries in human bronchial epithelial BEAS-2B cells and explore the underlying mechanism.

Methods: BEAS-2B cells exposed to CSE were treated with normal rat serum, BYF-medicated rat serum at low or high doses, pyrrolidine dithiocarbamate (PDTC, a NF-κB inhibitor), PDTC combined with high-dose BYF-medicated serum, or S-carbomethyloysteine (S-CMC, as the positive control). CCK-8 assay was used to determine the optimal concentration and treatment time of CSE, BYF-medicated serum and S-CMC.

Comparisons of the QLICP-HN and FACT-H&N instruments for measuring quality of life in patients with head and neck cancer.

Background: Two head and neck cancer quality-of-life(QoL) measurement tools, the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) and the Quality of Life Instruments for Cancer Patients-Head and Neck Cancer (QLICP-HN), are widely used in China, but several researchers tend to be confused about which QoL measurement tool to choose before conducting QoL measurements. This investigation aimed to employ data procured from patients diagnosed with head and neck cancer to conduct a comparative analysis of these two assessment tools.

Methods: Questionnaire outcomes were scrutinized at the subscale level by utilizing scale measurement analytics, correlation evaluation, validation examination, and association analyses.

More Comfortable Enjoyment for Upper Eyelid Blepharoplasty: Optimization of Anesthesia Methods Using Stepwise Local Anesthesia Technique.

Background: Perceived pain during local anesthesia injections in double-eyelid blepharoplasty can be influenced by both the epinephrine concentration and local anesthetics components. This study aimed to explore a new stepwise local anesthesia method for upper eyelid blepharoplasty, utilizing ropivacaine mixed with lidocaine, stepwise increase in epinephrine concentration infiltration, and stepwise specific anesthesia application during two surgical procedures.

Methods: A prospective randomized clinical trial was conducted on a cohort of patients undergoing upper double-eyelid blepharoplasty, who were randomly divided into two distinct groups: conventional local anesthesia and stepwise anesthetic method.

Surgical Outcomes With Neoadjuvant Durvalumab Plus Chemotherapy Followed by Adjuvant Durvalumab in Resectable NSCLC.

Introduction: In AEGEAN, perioperative durvalumab plus neoadjuvant chemotherapy, versus neoadjuvant chemotherapy alone, significantly improved event-free survival (p = 0.004) and pathologic complete response (p < 0.001; primary end points; modified intention-to-treat [mITT] population, which excluded patients with known EGFR or ALK aberrations) with a manageable safety profile in patients with resectable (R)-NSCLC.

[Retracted] Everolimus inhibits the proliferation and migration of epidermal growth factor receptor-resistant lung cancer cells A549 via regulating the microRNA-4328/phosphatase and tensin homolog signaling pathway.

[This retracts the article DOI: 10.3892/ol.2019.

Inhibition of LINC01048 decreases cell proliferation and induces the apoptosis in gastric cancer.

With advancements in the study of long non-coding RNAs (lncRNAs) as significant biomarkers and therapeutic targets in various human diseases, including cancer, neurodegenerative conditions, and genetic disorders, emerging evidence highlights their regulatory roles in the development of gastric cancer (GC). However, the mechanisms underlying these functions remain largely unknown. In this study, we investigate the role of the LINC01048 in tumorigenesis and cell proliferation in GC cell lines, such as HGC27 and MKN45.

Wide Double-Eyelid Fold Repair Using an Orbital Septum Flap and an Suborbicularis Oculi Fascial-Fat Flap in Cases Requiring Preservation of the Original Incision Scar.

Background: Double-eyelid blepharoplasty is a common cosmetic surgery. However, blepharoplasty can lead to poor results, necessitating repair surgery. One of the most frequent poor results after double-eyelid blepharoplasty is an excessively wide double-eyelid fold.

Advances in Antibody-Drug Conjugates for Endometrial Cancer.

The treatment of advanced endometrial cancer is clinically challenging, prompting the exploration of innovative therapeutic strategies such as antibody-drug conjugates (ADC). ADCs, which include mAbs, cytotoxic components, and linkers, demonstrate robust targeting, cytotoxicity, and manageable adverse effects. To provide a thorough understanding of the status of research, this review elucidates promising therapeutic targets in endometrial cancer, such as HER2, folate receptor α, and trophoblast surface antigen-2, and summarizes preclinical and clinical trial data on related ADC drugs in endometrial cancer.

Efficacy and safety of induction immunochemotherapy followed by radiotherapy for patients with unresectable locally advanced non-small cell lung cancer: A retrospective study.

Objectives: Immune checkpoint inhibitor (ICI) has displayed considerable advantages in consolidation therapy of locally advanced non-small cell lung cancer (LA-NSCLC) after concurrent chemoradiotherapy (cCRT). However, many patients are considered unsuitable for cCRT owing to concerns with tolerability. In this study, we aimed to assess the efficacy and toxicity of induction immunochemotherapy followed by radiotherapy for unresectable LA-NSCLC who are not capable of receiving cCRT.

Ivonescimab versus pembrolizumab for PD-L1-positive non-small cell lung cancer (HARMONi-2): a randomised, double-blind, phase 3 study in China.

Background: Ivonescimab is a bispecific antibody against programmed cell death protein 1 and vascular endothelial growth factor, yielding promising clinical outcomes for patients with advanced non-small cell lung cancer in early-phase studies. We compared the efficacy and safety of ivonescimab with pembrolizumab in patients with programmed cell death ligand-1 (PD-L1)-positive advanced non-small cell lung cancer.

Methods: HARMONi-2 is a randomised, double-blind, phase 3 trial across 55 hospitals in China.

[Analysis of Clinical Epidemiological Characteristics of 15,967 Lung Cancer Surgery Patients in Yunnan Cancer Hospital from 2013 to 2022].

Background: Lung cancer is a disease with a high incidence rate in Yunnan province, yet there is a paucity of large-scale studies on its clinical epidemiology. This research aims to investigate the epidemiological characteristics of patients who underwent lung cancer surgery at Yunnan Cancer Hospital over the past decade, thereby providing a theoretical basis for the prevention and treatment of lung cancer.

Methods: Clinical data were collected from 15,967 patients who underwent lung cancer surgery at Yunnan Cancer Hospital between 2013 and 2022.

Development of a prognostic nomogram and risk stratification system for elderly patients with esophageal squamous cell carcinoma undergoing definitive radiotherapy: a multicenter retrospective analysis (3JECROG R-03 A).

Background: Our goal is to develop a nomogram model to predict overall survival (OS) for elderly esophageal squamous cell carcinoma (ESCC) patients receiving definitive radiotherapy (RT) or concurrent chemoradiotherapy (CRT), aiding clinicians in personalized treatment planning with a risk stratification system.

Methods: A retrospective study was conducted on 718 elderly ESCC patients treated with RT or CRT at 10 medical centers (3JECROG) from January 2004 to November 2016. We identified independent prognostic factors using univariate and multifactorial Cox regression to construct a nomogram model.

Predicting lymph node metastasis of clinical T1 non-small cell lung cancer: a brief review of possible methodologies and controversies.

Non-small cell lung cancer (NSCLC) is a major subtype of lung cancer and poses a serious threat to human health. Due to the advances in lung cancer screening, more and more clinical T1 NSCLC defined as a tumor with a maximum diameter of 3cm surrounded by lung tissue or visceral pleura have been detected and have achieved favorable treatment outcomes, greatly improving the prognosis of NSCLC patients. However, the preoperative lymph node staging and intraoperative lymph node dissection patterns of operable clinical T1 NSCLC are still subject to much disagreement, as well as the heterogeneity between primary tumors and metastatic lymph nodes poses a challenge in designing effective treatment strategies.

The Efficacy of Anlotinib Plus Whole Brain Radiotherapy in Advanced Non-Small Cell Lung Cancer With Multiple Brain Metastases: A Retrospective Study.

Purpose: This study aimed to compare the efficacy of anlotinib plus whole-brain radiotherapy (WBRT) with that of WBRT alone in non-small cell lung cancer (NSCLC) patients with multiple brain metastases (BMs).

Methods: The clinical data of patients with NSCLC and multiple BMs who received WBRT between 2019 and 2022 were collected. The patients were assigned to anlotinib plus WBRT group and WBRT group according to the treatment used.

Modified Mucosal Advancement Flap Combined With De-Epithelialized Mucosal Flap for Labia Minora Hypertrophy.

Background: This study aimed to explore a novel and effective modified technique for the improvement in labia minora hypertrophy.

Methods: From January 2020 to December 2022, 25 patients with labia minora hypertrophy underwent surgical treatment using a modified mucosal advancement flap combined with a de-epithelialized mucosal flap for labia minora reduction. Postoperative follow-up ranged from 3 to 12 months.

Facile synthesis of carbon-coated CoS micro/nano-spheres as high-performance anode materials for sodium-ion batteries.

carbon-coated CoS micro/nano-spheres were successfully prepared by sulfuric calcination using the solvothermal method with glycerol as the carbon source without introducing extraneous carbon. This method prevents carbon agglomeration and avoids the cumbersome steps of the current technology. The composite demonstrates excellent sodium storage capacity as an anode material for sodium-ion batteries.