RBM24-mediated biogenesis of circ23679 protects cardiomyocytes against apoptosis via sponging miR-15b-5p.

Circular RNAs (circRNAs) have emerged as significant members of gene regulatory networks and play important roles in normal heart biology and cardiac diseases. RNA binding proteins (RBPs) are key regulatory factors in circRNA formation; however, the mechanisms by which RBP regulate circRNA production remain unclear. RNA binding motif protein 24 (RBM24) is essential for alternative splicing of genes related to cardiac function, and its loss leads to dilated cardiomyopathy and heart failure.

Comparative analysis of formulae for umbilical venous catheterization depth based on birth weight.

Importance: Umbilical venous catheterization (UVC) is a common procedure for critically ill newborn infants. The insertion depth was estimated before the procedure using various formulae.

Objective: To compare the accuracy of five published formulae based on birth weight (BW).

A comparative study of S-nitrosylated myofibrillar proteins between red, firm and non-exudative (RFN) and pale, soft and exudative (PSE) pork by iodoTMT-based proteomics assay.

In this paper, the S-nitrosylated myofibrillar protein in pork was comparatively analyzed between pale, soft, and exudative (PSE) and red, firm, and non-exudative (RFN) meat. The S-nitrosothiol and immunoblot of S-nitrosylated protein indicated that the overall protein S-nitrosylation level in PSE pork was higher than that in RFN pork. Proteomics showed that 114 SNO-modified cysteines corresponding to 65 proteins were over-expressed in PSE samples while 74 nitrosylated cysteines of 20 proteins were over-expressed in RFN samples.

The Efficacy of Orthodontics plus Implant Anchorage in Orthodontic Treatment: A Randomized Controlled Study.

Objective: To investigate the efficacy of orthodontics plus implant anchorage in orthodontic treatment.

Methods: This randomized controlled study was conducted on 90 patients who had orthodontic treatment in our hospital between October 2019 and October 2020, and they were assigned to either a control group ( = 45) or an observation group ( = 45) via the random number table method. Patients in the control group received orthodontics while those in the observation group underwent orthodontics plus implant anchorage.

Effect of nitric oxide treatment on pork meat quality, microstructure, and total bacterial count during postmortem aging.

In this paper, the potential effect of nitric oxide (NO) on improving the fresh meat quality of pork was primarily investigated by treatment of longissimus thoracis (LT) with 0, 20, 40, 60, 80 μL/L NO gas within 6 h post-slaughter. After the NO treatments were completed, the pork chops were vacuum-packaged and stored at 4 °C for 1, 4, and 7 d. Compared with the control group, NO treatment enhanced ultimate pH and a* value, and decreased the total bacterial count.

Improvement strategies for quality defects and oxidation of pale, soft and exudative (PSE)-like chicken meat: effects of domestic cooking and core temperature.

This study compared the quality, oxidation, and microstructure of high-market-share PSE-like chicken meat (PSE) after domestic cooking with those of normal chicken meat (NOR). Cooking techniques included steaming (ST), boiling (BO), roasting (RO), and microwaving (MV) at 60, 70, and 80 °C. The results indicated that PSE-induced chicken breasts were of poor quality, with significantly higher cooking loss rates (NOR: 22.

Comparative Study on Pale, Soft and Exudative (PSE) and Red, Firm and Non-Exudative (RFN) Pork: Protein Changes during Aging and the Differential Protein Expression of the Myofibrillar Fraction at 1 h Postmortem.

In this paper, the protein changes during aging and the differences in the myofibrillar protein fraction at 1 h postmortem of pale, soft and exudative (PSE), and red, firm and non-exudative (RFN) pork (LT) were comparatively studied. The PSE and RFN groups were screened out based on the differences in their pH and lightness () at 1 h, and their purge loss at 24 h postmortem. Based on the measured MFI, desmin degradation, and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis, PSE meat presented more significant changes in the myofibrillar protein fraction compared to RFN meat during postmortem aging.

Circular RNA TRAPPC6B inhibits intracellular growth while inducing autophagy in macrophages by targeting microRNA-874-3p.

Objectives: Genetic and epigenetic mechanisms regulate antimicrobial immunity against (Mtb) infection.

Methods: The present study assessed circular RNA TRAPPC6B (circTRAPPC6B) for antimicrobial immune functions and defined mechanisms wherein circTRAPPC6B regulates Mtb growth, autophagy and microRNA in macrophages.

Results: The Mtb infection of monocytes/macrophages resulted in a significantly decreased level of circTRAPPC6B that inhibited intracellular Mtb growth in macrophages.

Effect of prophylactic transcatheter arterial chemoembolization on hepatocellular carcinoma with microvascular invasion after R0 resection. A case-control study.

Background: Transcatheter arterial chemoembolization (TACE) is thought to prevent recurrence of hepatocellular carcinoma (HCC), but its efficacy is a matter of controversy.

Objectives: We investigated the effect of preventive TACE on the tumor, nodes, metastasis (TNM) classification in cases of stage II HCC (T2N0M0) after R0 resection.

Design And Setting: Case-control study conducted in a tertiary-level public hospital.

CircRNA_0000502 promotes hepatocellular carcinoma metastasis and inhibits apoptosis through targeting microRNA-124.

Purpose: To investigate the expression level of circ_0000502 in hepatocellular carcinoma (HCC), and to further explore whether it can promote the malignant progression of HCC by targeting and binding to microRNA (miR)-124.

Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was used to detect the expression level of circ_0000502 in 40 pairs of HCC tissue specimens and adjacent ones, and to analyze the relationship between circ_0000502 expression and prognosis of patients with HCC. QRT-PCR was used to verify the expression of circ_0000502 in HCC cells.

Advantages of laparoscopic common bile duct exploration in common bile duct stones.

Objective: To compare the efficacy, safety, and surgical outcomes of laparoscopic common bile duct exploration, endoscopic retrograde cholangiopancreatography, and open common bile duct exploration for treatment of common bile duct stones.

Methods: In total, 210 patients were prospectively randomized into 3 groups: laparoscopic common bile duct exploration, endoscopic retrograde cholangiopancreatography, and open common bile duct exploration. The primary outcome measures were the common bile duct stone clearance rate and the complication rate.