Factors associated with secondary thoracotomy for hemostasis following lung surgery: a retrospective analysis.

Purpose: This study aimed to systematically investigate the causes and management of secondary thoracotomy for hemostasis following lung cancer surgery. Although infrequent, secondary thoracotomy can lead to prolonged hospitalization, increased costs, and additional patient trauma. However, prior research has been limited to case reports or experience-based summaries, lacking a comprehensive analysis of this issue.

Sleeping quality, sleeping habits, and their association with BMI in children in southern China.

Objectives: This study analyzes the effects of sleep quality along with sleep duration and bedtime on BMI in children aged 3-12 years and explores their role in the occurrence and development of obesity in children.

Methods: This study conducted a cross-section study on children in 18 cities and counties of Hainan Province. The Children's Sleep Habits Questionnaire (CSHQ), along with a parents-report children's features survey, was used to assess children's sleep quality and habits, among other factors.

SUMO modified ETV1 promotes M2-polarized tumor-associated macrophage infiltration and cancer progression by facilitating CCL2 transcription in esophageal squamous cell carcinoma cells.

Objective: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with a high metastasis rate and a poor prognosis. ETS variant transcription factor 1 (ETV1) plays an important role in multiple malignancies. However, its function in ESCC progression and tumor microenvironment (TME) remains to be explored.

Simultaneously Enhanced Permeability and Selectivity of Pebax-1074-Based Mixed-Matrix Membrane for CO Separation.

Membrane technology is a promising methodology for carbon dioxide separation due to its benefit of a small carbon footprint. However, the trade-off relationship between gas permeability and selectivity is one obstacle to limiting its application. Herein, branched polyethyleneimine (BPEI) containing a rich amino group was successfully grafted on the surface of the metal-organic framework (MOF) of AIFFIVE-1-Ni (KAUST-8) through coordination between N in BPEI and open metal sites in the MOF and with the resultant maintained BET surface area and pore volume.

Vitamin D Deficiency and Associated Factors in Children: A Multicenter Study of 21,811 Samples in Southern China.

Objective: To investigate the prevalence of vitamin D deficiency (VDD) in children/adolescents in extreme southern China.

Methods: This multicenter, cross-sectional study included 21,811 children aged 0-18 years from 18 districts in Hainan Province, using a multistage stratified random sampling method from January 2021 to March 2022.

Results: Serum 25(OH)D levels decreased with age (p trend <0.

Three-Dimensional Quantitative Structure-Activity Relationship, Antimicrobial Activity, and Molecular Docking Studies of C-14 Chiral Matrine Derivatives as Potential Antibiotics.

Antibiotic resistance is recognized as one of the top ten global public health threats, posing a significant challenge to human health. The stereochemistry of chiral molecules, alongside their specific interactions with biological targets, provides essential insights for the development of novel antibacterial agents, This study investigated the antibacterial activity of 32 previously synthesized 14-position chiral matrine derivatives. Among these derivatives, compound Q4 exhibited the strongest activity against Propionibacterium acnes, with a minimum inhibitory concentration (MIC) of 0.

Phillygenin improves diabetic nephropathy by inhibiting inflammation and apoptosis via regulating TLR4/MyD88/NF-κB and PI3K/AKT/GSK3β signaling pathways.

Background: Phillygenin (PHI), a main bioactive compound found in the fruit of Forsythia suspensa, exhibits antiviral, antioxidant, anti-inflammatory, and antihypertensive activities. However, the molecular mechanisms underlying its effects on diabetic nephropathy (DN) remain unclear.

Purpose: To evaluate the therapeutic effects of PHI on DN and elucidate the molecular mechanisms involved.

FOXF2 suppressed esophageal squamous cell carcinoma by reducing M2 TAMs via modulating RNF144A-FTO axis.

Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers because of its high invasiveness and low survival. Tumor-associated macrophages (TAMs) are closely associated with the tumor cell proliferation, metastasis and immunosuppression. As a member of the FOX family, forkhead box F2 (FOXF2) was down-regulated in ESCC.

Design, synthesis and biological evaluation of matrine contains benzimidazole derivatives as dual TOPOI and PARP inhibitors for cancer therapy.

TOPOI inhibitors have long been a focal point in the research and development of antitumor drugs. PARP-1 plays a crucial role in repairing DNA damage induced by TOPOI inhibitors. Thus, concurrent inhibition of TOPOI and PARP-1 has the potential to augment drug activity.

Novel chiral matrine derivatives as potential antitumor agents: Design, synthesis and biological evaluation.

Since the thalidomide incident, research on chiral drugs has escalated immensely. Differences in drug configuration can lead to significant variations in therapeutic efficacy. Matrine, a natural product esteemed for its low toxicity and high water solubility, has garnered significant attention in research endeavors.

The intervention of cannabinoid receptor in chronic and acute kidney disease animal models: a systematic review and meta-analysis.

Aim: Cannabinoid receptors are components of the endocannabinoid system that affect various physiological functions. We aim to investigate the effect of cannabinoid receptor modulation on kidney disease.

Methods: PubMed, Web of Science databases, and EMBASE were searched.

Early vascular changes after silicone oil removal using optical coherence tomography angiography.

Background: This study evaluated the vascular changes in the macular and peripapillary regions before and after silicone oil (SO) removal in patients with rhegmatogenous retinal detachment.

Methods: This single-center case series assessed patients who underwent SO removal at one hospital. Patients who underwent pars plana vitrectomy and perfluoropropane gas tamponade (PPV + CF) were selected as controls.

Different lens power calculation formulas for the prediction of refractive outcome after phacoemulsification with silicone oil removal.

Background: Formulas predicting intraocular lens power have not been compared in silicone oil-tamponaded eyes. The study aims to compare six intraocular lens power assessment formulas in silicone oil-tamponaded eyes.

Methods: This prospective study included patients with silicone oil-tamponaded eyes scheduled for silicone oil removal, phacoemulsification, and intraocular lens implantation at Chongqing Aier Eye Hospital (June 2019 to December 2019).

Metabolic Understanding of the Genetic Dysregulation in the Tumor Microenvironment of Kidney Renal Clear Cell Carcinoma.

The metabolic dysregulation is a hallmark of cancers including KIRC, specifically caused by alterations in metabolic genes. Currently, a lack of consensus exists between metabolic signatures in the tumor microenvironment. Here, in this study, we observed the significant correlations of differentially expressed metabolic genes (DEmGs) between KIRC and the related normal samples.

HNRNPA1-mediated exosomal sorting of miR-483-5p out of renal tubular epithelial cells promotes the progression of diabetic nephropathy-induced renal interstitial fibrosis.

Diabetic nephropathy (DN) is a serious complication in type 1 and type 2 diabetes, and renal interstitial fibrosis plays a key role in DN progression. Here, we aimed to probe into the role and potential mechanism of miR-483-5p in DN-induced renal interstitial fibrosis. In this study, we corroborated that miR-483-5p expression was lessened in type 1 and type 2 diabetic mice kidney tissues and high glucose (HG)-stimulated tubular epithelial cells (TECs), and raised in the exosomes derived from renal tissues in type 1 and type 2 diabetic mice.

Non-stationary component extraction in noisy multicomponent signal using polynomial chirping Fourier transform.

Inspired by track-before-detection technology in radar, a novel time-frequency transform, namely polynomial chirping Fourier transform (PCFT), is exploited to extract components from noisy multicomponent signal. The PCFT combines advantages of Fourier transform and polynomial chirplet transform to accumulate component energy along a polynomial chirping curve in the time-frequency plane. The particle swarm optimization algorithm is employed to search optimal polynomial parameters with which the PCFT will achieve a most concentrated energy ridge in the time-frequency plane for the target component.

Characterization and photocatalytic properties of Ni-doped Sr(10)Bi(6)O(24-y).

The compound Sr(10)Bi(6)O(24-y) doped with Ni was prepared by solid-state reaction method. The obtained powders were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), UV-vis diffuse reflectance spectra and X-ray photoemission spectra (XPS). The Ni-doped Sr(10)Bi(6)O(24-y) samples assume a cubic perovskite structure with space group Fm3m (225).