Effects of positive psychological interventions on quality of life in patients with first-episode depression.

Objective: This study aims to investigate the effects of positive psychological interventions (PPIs) on improving the quality of life in first-episode depression patients.

Methods: A total of 200 first-episode depression patients were randomly assigned to a control group (n=100, conventional nursing) or a study group (n=100, conventional care plus four weekly 60-80-minute PPI sessions over one month). Depression severity (Hamilton Depression Rating Scale, HAMD), psychological resilience (Connor-Davidson Resilience Scale, CD-RISC), self-acceptance (Self Acceptance Questionnaire, SAQ), and quality of life (SF-36) were assessed pre-intervention and 3 months post-intervention.

Design, synthesis and biological evaluation of matrine contains benzimidazole derivatives as dual TOPOI and PARP inhibitors for cancer therapy.

TOPOI inhibitors have long been a focal point in the research and development of antitumor drugs. PARP-1 plays a crucial role in repairing DNA damage induced by TOPOI inhibitors. Thus, concurrent inhibition of TOPOI and PARP-1 has the potential to augment drug activity.

The diagnostic value of cognitive assessment indicators for mild cognitive impairment (MCI).

Objective: This study aims to evaluate and analyze the standard diagnostic methods for mild cognitive impairment (MCI).

Methods: This study used a prospective case-control study to examine baseline data and diagnostic indicators in a population of elderly with MCI. Based on different cognitive abilities, this study divided MCI and healthy control groups.

Treatment outcomes and cognitive function following electroconvulsive therapy in patients with severe depression.

Background: Traditional treatments for major depressive disorder (MDD), including medication and therapy, often fail and have undesirable side effects. Electroconvulsive therapy (ECT) uses electrical currents to induce brief seizures in the brain, resulting in rapid and potent antidepressant effects. However, owing to misconceptions and controversies, ECT is not as widely used as it could and often faces stigmatization.

Induction of Apoptosis by Matrine Derivative ZS17 in Human Hepatocellular Carcinoma BEL-7402 and HepG2 Cells through ROS-JNK-P53 Signalling Pathway Activation.

Hepatocellular carcinoma (HCC) is one of the most common malignancies and ranks third among cancer-related deaths worldwide. Using matrine as a lead compound, 12 matrine derivatives were designed and synthesised, and their antiproliferative activities were evaluated in four cancer cell lines. Eight of the twelve compounds showed strong antiproliferative activity, with an IC50 of <10 μM.

Novel matrinic acid derivatives bearing 2-anilinothiazole structure for non-small cell lung cancer treatment with improved Hsp90 targeting effect.

Involved in mediating the folding and maturation of more than 300 client proteins, many of which are oncoproteins, Hsp90 has emerged as a promising drug target for cancer therapy. In particular, inhibiting Hsp90 plays a vital role in the treatment of non-small cell lung cancer. Owing to undesirable outcomes of Hsp90 inhibitors in clinical trials, a series of matrinic acid compounds bearing 2-anilinothiazole moiety were designed based on the structural features allocation shared among Hsp90 inhibitors within the ATP-binding pocket.

Effects of shift work on sleep and cognitive function among male miners.

Shift work is associated with circadian rhythm disruption that manifests in several aspects related to sleep disorder, including trouble falling asleep, shortened sleep, and daytime fatigue. The objective of this study was to investigate the effects of shift work on sleep and cognitive function in the middle-aged male miners in Kailuan Mining Group. From May 2013 to May 2015, male miners were recruited and enrolled in prospective study.

Childhood physical neglect promotes development of mild cognitive impairment in old age - A case-control study.

This study aimed to investigate the role of early traumatic experiences in development of mild cognitive impairment (MCI) in Chinese elderly people. Seventy six patients and 61 controls were selected and assigned into two study groups, MCI and control, respectively. Childhood Trauma Questionnaire-Short Form (CTQ-SF) was used for assessment of early trauma, episodic memory and association learning scales for memory evaluation.

High prevalence of mild cognitive impairment in the elderly: a community-based study in four cities of the Hebei province, china.

Background: Mild cognitive impairment (MCI) has been suggested as a term for a boundary area between normal aging and dementia. This study was designed to determine the prevalence of MCI in the elderly in the Hebei province, China, and explore its related factors.

Methods: Participants included 2,601 community-dwelling people aged 60 years or older who resided in the four major cities of the Hebei province.