Rethinking folic acid fortification: A call for nuanced strategies and broader investigations.

This comment letter responds to Edward H. Reynolds' comprehensive review on folate, vitamin B12, one‑carbon metabolism, and nervous system health. While commending the review's insights into the potential neurological harms of excess folic acid, especially with vitamin B12 deficiency, we expand on several critical areas.

Regarding "Stoma site extraction does not increase complication rates in robot-assisted colorectal surgery": a call for nuance in patient selection, long-term scrutiny, and methodological rigor.

This correspondence responds to the study by Stahl et al. on stoma site extraction (SSE) in robot-assisted colorectal surgery. While we commend the authors for addressing this important technical question, we raise critical concerns regarding the study's methodological limitations.

Navigating the paradoxes and potential of digital phenotyping for bipolar relapse prediction.

This commentary responds to the important study by Ludwig et al. on using smartphone data and critical slowing down (CSD) to predict bipolar disorder (BD) relapse. While commending the study's methodological rigor, we highlight a key paradoxical finding: a decrease in activity variance preceding manic episodes, which challenges the classic CSD model.

Human exposure to organophosphate esters (OPEs): A meta-analytic review of levels and distribution.

With the global increase in organophosphate ester (OPE) usage, contamination has extended beyond environmental media into the human body, raising significant biosafety concerns. In this study, we conducted a meta-analysis of 254,581 data points from 98 studies spanning multiple regions worldwide. This large-scale synthesis allowed us to minimize regional bias and generate a quantitative profile of human OPE contamination and related risks.

Research and design experience of a 1 million tons/year CO capture project in the Shengli oilfield of Qilu petrochemical.

This study presents a comprehensive overview of a pioneering 1 million-ton carbon capture, utilization, and storage (CCUS) project implemented in the Qilu Petrochemical Shengli Oilfield in China. The project involved a compression-condensation-purification process and aimed to capture CO from the coal gas of the second chemical fertiliser plant of the Qilu Petrochemical Company. Molecular sieves were used to dry the captured CO, and MellapakPlus™ structured packing was employed for purification.

Unpacking mortality in Alzheimer's and pneumonia: key considerations for future analysis.

This letter comments on the recent study by Javaid et al. regarding mortality trends at the nexus of pneumonia and Alzheimer's disease (AD). While acknowledging the study's important contributions to identifying public health disparities, we propose three key analytical refinements to build upon their findings.

Prevalence and long-term outcomes of NAFLD and cardiovascular-kidney-metabolic health in the United States.

Background And Aims: To explore non-alcoholic fatty liver disease (NAFLD)'s role within the novel cardiovascular-kidney-metabolic (CKM) syndrome framework, given their overlapping pathophysiological mechanisms.

Methods: We analyzed 10,985 U.S.

Real-world challenges for guideline-directed medical therapy intolerance in heart failure: A single-center prospective cohort study.

Backgrounds: The use of guideline-directed medical therapy (GDMT) in heart failure (HF) has been shown to decrease hospitalization and mortality risks. However, the implementation of GDMT remains suboptimal. This study aimed to evaluate the challenges of GDMT intolerance in a real-world setting.

AG86 Peptide-modified Reactive Oxygen Species-responsive Polymer Nanovesicles for Transdermal Delivery of Hydrophilic Ergothioneine to Basal Keratinocytes.

This study aims to develop a multifunctional polymer nanovesicle system, AG86-β-glucan-poly(methionine-b-carboxybetaine) (AGPMC), which integrates AG86 peptide (a targeting ligand for the α6β4 integrin on basal keratinocytes) and reactive oxygen species (ROS) responsiveness to enhance the transdermal delivery of ergothioneine (EGT). The objective is to overcome the limitations of hydrophilic drug delivery and provide a targeted, ROS-triggered strategy for treating skin lipofuscin. AGPMC was synthesized via RAFT and ROP polymerization and self-assembles into stable nanovesicles (ANVs).

Nafamostat Mesylate Regulates Glycosylation to Alleviate Aristolochic Acid Induced Kidney Injury.

Acute kidney injury (AKI) is a condition with a poor prognosis, exacerbated by the lack of effective therapeutic options and inadequately understood underlying mechanisms. Glycosylation, a post-translational modification of proteins, is essential for maintaining protein stability and function, and its dysregulation leads to protein misfolding and amyloid aggregation. Glycosylation dynamics are implicated in several pathologies, including inflammation, cancer, and AKI, highlighting the therapeutic potential of regulating glycosylation and preventing aggregation in AKI treatment.

Construction of fibrin-targeted nanoparticles for imaging diagnosis and treatment of arterial thrombosis.

The clinical application of conventional thrombolytic drugs is limited due to the difficulty in precisely targeting the thrombus site and side effects such as severe bleeding. In order to specifically image thrombus for diagnosis and thrombolytic therapy, a CREKA-targeted and pH-responsive drug release nano-delivery system, called LK/PDB/IR820-CREKA NPs, was constructed. experiments showed that NPs had good pH responsiveness and biocompatibility.

Automated xeno-free chondrogenic differentiation from human embryonic stem cells: Enhancing efficiency and ensuring high-quality mass production.

Introduction: Repairing damaged cartilage poses significant challenges, particularly in cases of congenital cartilage defects such as microtia or congenital tracheal stenosis, or as a consequence of traumatic injury, as the regenerative potential of cartilage is inherently limited. Stem cell therapy and tissue engineering offer promising approaches to overcome these limitations in cartilage healing. However, the challenge lies in the size of cartilage-containing organs, which necessitates a large quantity of cells to fill the damaged areas.

Living plant-assisted recycling of nano gold into Murray porous carbon electrode materials.

Based on the enrichment potential of living plants for nanoparticles, this paper develops a new strategy to utilize Murray's law in plants to remove various shapes of gold nanoparticles and, , convert them into Murray porous carbon. The inherent Murray network serves as an optimized hierarchical design and ensures the mechanical stability of the material, and Murray's law is employed to achieve uniform dispersion of nanoparticles , facilitating the preparation of metal nanoparticle-supported carbon materials.

Mechanism of modified danggui buxue decoction in glucocorticoid-induced osteoporosis: A discussion based on network pharmacology and molecular docking.

Objective: Glucocorticoid-induced osteoporosis (GIOP) represents a major complication arising from the long-term use of glucocorticoids, which are widely prescribed for various inflammatory and autoimmune conditions. Despite its prevalence, the current therapeutic options for GIOP are limited in terms of efficacy, safety profiles, and patient compliance. The Modified Danggui Buxue Decoction (DGBXD), a traditional Chinese herbal formulation, has shown promise in preliminary studies for its potential osteoprotective effects.

Exploring organophosphate ester contamination and distribution in food: A meta-analysis.

This study examines the food safety risk of organophosphate esters (OPEs) by analyzing data from 23 studies with 14,915 data points. We found EDP contamination highest in cereals, dairy, and meats, and TEHP most prevalent in vegetables and fruits, with contamination levels reaching 4.54 ng/g and 1.

Universal organophosphate pesticides detection by peptide based fluorescent probes.

In practical applications, the rapid and efficient detection of universal organophosphorus pesticides (OPs) can assist inspectors in quickly identifying the presence of OPs in samples. However, this presents a challenge for most well-established methods, typically designed to detect only a specific type of organophosphorus molecule at a time. In this proof-of-concept study, we draw inspiration from the structural similarities among OPs to develop innovative peptide-based fluorescence probes for the first time, which could efficiently detect a broad range of OPs within a mere 3 min.

Human intestinal organoid-derived PDGFRα + mesenchymal stroma enables proliferation and maintenance of LGR4 + epithelial stem cells.

Background: Intestinal epithelial cells derived from human pluripotent stem cells (hPSCs) are generally maintained and cultured as organoids in vitro because they do not exhibit adhesion when cultured. However, the three-dimensional structure of organoids makes their use in regenerative medicine and drug discovery difficult. Mesenchymal stromal cells are found near intestinal stem cells in vivo and provide trophic factors to regulate stem cell maintenance and proliferation, such as BMP inhibitors, WNT, and R-spondin.

Organophosphorus pesticide contaminants in fruits and vegetables: A -analysis.

The worldwide demand for organophosphorus pesticides (OPs) in food production has raised concerns about pesticide residues. Meta-analysis, proven effective in assessing contaminants like aflatoxins and organotin compounds, is applied here to comprehensively study OP contamination in fresh fruits and vegetables. Employing Comprehensive Meta-Analysis V3.

CoFe nanoalloys encapsulated in nitrogen-doped carbon for efficient nitrite electroreduction to ammonia.

Electrochemical nitrite (NO) reduction to ammonia (NH) can not only remove harmful NO in wastewater, but also produce valuable NH. Herein, a CoFe nanoalloy encapsulated in nitrogen-doped carbon (CoFe-NC) electrocatalyst was fabricated for nitrite reduction, which achieved a high NH Faraday efficiency of 94.5%, and a large NH yield of 4050.

A systematic review and meta-analysis of risk factors for reoperation after degenerative lumbar spondylolisthesis surgery.

Background: Considering the high reoperation rate in degenerative lumbar spondylolisthesis (DLS) patients undergoing lumbar surgeries and controversial results on the risk factors for the reoperation, we performed a systematic review and meta-analysis to explore the reoperation rate and risk factors for the reoperation in DLS patients undergoing lumbar surgeries.

Methods: Literature search was conducted from inception to October 28, 2022 in Pubmed, Embase, Cochrane Library, and Web of Science. Odds ratio (OR) was used as the effect index for the categorical data, and effect size was expressed as 95% confidence interval (CI).

Carbon emission reduction policy with privatization in an oligopoly model.

This study constructs a mixed oligopoly model that includes a public enterprise and two private enterprises. Game theory was adopted to explore the effects of carbon emission reduction policies. In addition, this study analyzes the optimal carbon emission trading prices and privatization decisions.

High-Stability Silver Nanowire-AlO Composite Flexible Transparent Electrodes Prepared by Electrodeposition.

Silver nanowire (AgNW) conductive film fabricated by solution processing was investigated as an alternative to indium tin oxide (ITO) in flexible transparent electrodes. In this paper, we studied a facile and effective method by electrodepositing AlO on the surface of AgNWs. As a result, flexible transparent electrodes with improved stability could be obtained by electrodepositing AlO.