Alkaline treatment assisted construction of N-MoCT-SnS@rGO aerogels for fast potassium-ion battery.

The development of high-performance potassium-ion batteries (PIBs) are plagued by favorable anode materials which could accommodate the large-sized K ion, achieving fast charging/discharging kinetics and superior cycle life simultaneously. In the present work, we propose a novel three-dimensional hybrid aerogel, N-MoCT-SnS@rGO, in which SnS nanosheets were uniformly anchored onto the elastic and conductive N-MoCT MXenes framework and subsequently encapsulated with reduced graphene oxide (rGO). SnS presents inherent layered configuration and low operating voltage while this unique aerogel architecture could simultaneously improve conductivity, structural integrity, and interfacial contact as well as provide multiple ion/electron transport channels.

Anchoring ultrafine Ru nanoparticles on cotton-derived self-standing carbon fibers as efficient cathode catalyst for Li-CO battery.

Li-CO batteries could capture and convert CO into a valuable energy storage medium. The slow kinetics and high activation barrier associated with the breakdown cleavage of discharge products pose a significant hurdle in the advancement of reversible Li-CO batteries. Herein, cotton-derived self-standing carbon fibers were utilized to disperse Ru nanoparticles which could avoid depletion of active sites caused by stacking of graphite-based supports.

S-Scheme CdS/Co₃S₄ Double-Shelled Hollow Nanoboxes for Enhanced Photocatalytic Hydrogen Evolution.

Developing S-scheme systems with high photocatalytic performance is crucial for long-term solar-to-hydrogen conversion. In this study, hollow cobalt tetrasulfide (CoS) nanoboxes (NBs), synthesized via sulfurization using zeolitic imidazolate framework (ZIF-67) as a template, are combined with cadmium sulfide (CdS) nanoparticles (NPs) to construct heterojunction photocatalysts under mild conditions. The optimized CdS/CoS double-shelled nanoboxes (DSNBs) achieved a superior photocatalytic hydrogen production rate of 23.

Heterojunction constructed from ZIF-8-on-MIL-68(Ga) precursor for photocatalytic CO reduction.

Herein, a ZIF-8-on-MIL-68(Ga) precursor derived ZnGaO/ZnO heterojunction can promote charge separation and has a strong photoredox ability, while decoration with a Au cocatalyst can lower the Gibbs free energy barrier of the rate-determining step in the photocatalytic CO reduction reaction, leading to a high CH yield of 21.1 μmol g h in pure water without any sacrificial reagent.

Molecular interactions between fibrinogen and 6-methoxydihydrosanguinarine and their modulation of anticancer activity in melanoma A375 cells.

Natural benzophenanthridine alkaloids such as sanguinarine, chelerythrine, and 6-methoxydihydrosanguinarine (6-MDS) possess anticancer properties against various cancer cell types. However, the physical interactions of these compounds with blood proteins and the anticancer effects of the resulting complex remain unknown. Therefore, in this study, the interaction between 6-MDS and fibrinogen (Fb) was evaluated through experimental and theoretical studies.

ZnInS enwrapping CoP with phosphorus vacancies hollow microspheres for efficient photocatalytic hydrogen production.

To address the pressing challenges of energy shortages and environmental sustainability, photocatalytic water splitting for hydrogen production has emerged as a promising strategy for solar energy conversion. While semiconductor catalysts exhibit significant potential in photocatalysis, their practical applications are hindered by limitations such as inefficient charge separation and insufficient active sites. Designing and preparing efficient, non-precious co-catalysts is therefore essential.

Stable quantum droplets with high-order vorticity in zero-order Bessel lattice.

A theoretical framework is presented to investigate the stability of novel two-dimensional quantum droplets within zeroth-order Bessel lattices. The evolution of quantum droplets is studied by the Gross-Pitaevskii equations with Lee-Huang-Yang corrections. The circular groove structure inherent in the zeroth-order Bessel lattice potential facilitates the formation of distinct configurations, including stable zero-vorticity annular quantum droplets and annular quantum droplets featuring embedded vorticity.

STAMBPL1/TRIM21 Balances AXL Stability Impacting Mesenchymal Phenotype and Immune Response in KIRC.

Kidney renal clear cell carcinoma (KIRC) is recognized as an immunogenic tumor, and immunotherapy is incorporated into its treatment landscape for decades. The acquisition of a tumor mesenchymal phenotype through epithelial-to-mesenchymal transition (EMT) is associated with immune evasion and can contribute to immunotherapy resistance. Here, the involvement of STAM Binding Protein Like 1 (STAMBPL1) is reported in the development of mesenchymal and immune evasion phenotypes in KIRC cells.

Cooperation between SIX1 and DHX9 transcriptionally regulates integrin-focal adhesion signaling mediated metastasis and sunitinib resistance in KIRC.

High invasive capacity and acquired tyrosine kinase inhibitors (TKI) resistance of kidney renal clear cell carcinoma (KIRC) cells remain obstacles to prolonging the survival time of patients with advanced KIRC. In the present study, we reported that sine oculis homeobox 1 (SIX1) was upregulated in sunitinib-resistant KIRC cells and metastatic KIRC tissues. Subsequently, we found that SIX1 mediated metastasis and sunitinib resistance via Focal adhesion (FA) signaling, and knockdown of SIX1 enhanced the antitumor efficiency of sunitinib in KIRC.

Unveiling the bifunctional roles of Cetyltrimethylammonium bromide in construction of NbCT@MoSe heterojunction for fast potassium storage.

Exploring robust electrode materials which could permit fast and reversible insertion/extraction of large K is a crucial challenge for potassium-ion batteries (PIBs). Smart interfacial design could facilitate electron/ion transport as well as assure the integrity of electrode. Herein, Cetyltrimethylammonium bromide (CTAB) was found to play bifunctional roles in construction of NbCT@MoSe heterostructure.

Appearance quality, nutritional value, and aroma components of wild diguo ( Bur.) fruit collected from southwest China.

Diguo ( Bur.), an ancient wild fruit, is widely spread in southwest China. However, there is little information on the phenotypic traits, quality characteristics, and aroma compounds available to diguo fruit.

Modeling Tree-like Heterophily on Symmetric Matrix Manifolds.

Tree-like structures, characterized by hierarchical relationships and power-law distributions, are prevalent in a multitude of real-world networks, ranging from social networks to citation networks and protein-protein interaction networks. Recently, there has been significant interest in utilizing hyperbolic space to model these structures, owing to its capability to represent them with diminished distortions compared to flat Euclidean space. However, real-world networks often display a blend of flat, tree-like, and circular substructures, resulting in heterophily.

Edge-oriented growth of cadmium sulfide nanoparticles on nickel metal-organic framework nanosheets for photocatalytic hydrogen evolution.

In this study, a directional loading of cadmium sulfide (CdS) nanoparticles (NPs) was achieved on the opposite edges of nickel metal-organic framework (Ni-MOF) nanosheets (NSs) by adjusting the weight ratio of CdS NPs in the reaction process to produce effective visible light photocatalysts. The close contact between the zero-dimensional (0D) and two-dimensional (2D) regions and the matching positions of the bands promoted charge separation and heterojunction formation. The optimal CdS NPs loading of composite material was 40 wt%.

GHITM regulates malignant phenotype and sensitivity to PD-1 blockade of renal cancer cells via Notch signalling.

Growth hormone inducible transmembrane protein (GHITM), one member of Bax inhibitory protein-like family, has been rarely studied, and the clinical importance and biological functions of GHITM in kidney renal clear cell carcinoma (KIRC) still remain unknown. In the present study, we found that GHITM was downregulated in KIRC. Aberrant GHITM downregulation related to clinicopathological feature and unfavourable prognosis of KIRC patients.

Elastic MXene conductive layers and electrolyte engineering enable robust potassium storage.

The precisely engineered structures of materials greatly influence the manifestation of their properties. For example, in the process of alkali metal ion storage, a carefully designed structure capable of accommodating inserted and extracted ions will improve the stability of material cycling. The present study explores the uniform distribution of self-grown carbon nanotubes to provide structural support for the conductive and elastic MXene layers of TiCT-Co@NCNTs.

Architecting carbon-coated MoCT/MoSe heterostructures enables robust potassium storage.

Herein, carbon-coated MoSe decorated MoCT MXene heterostructures (MoSe/MoCT@C) have been fabricated. MoCT works as a dual-function electron/ion conductor, which not only provides high conductivity and mechanical strength, but also prevents the severe self-aggregation of few layered MoSe nanosheets. The high reversible capacities of 405 mA h g at 100 mA g after 150 cycles and 258 mA h g at 2000 mA g after 400 cycles could be achieved for a potassium-ion battery.

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer.

Objectives: DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.

Methods: The inhibition of DOT1L was used by SGC0946 and short hairpin RNA silencing.

Solvent- and Co-Catalyst-Free Cycloaddition of Carbon Dioxide and Epoxides Catalyzed by Recyclable Bifunctional Niobium Complexes.

CO, as a cheap and abundant renewable C1 resource, can be used to synthesize high value-added chemicals. In this paper, a series of bifunctional metallic niobium complexes were synthesized and their structures were characterized by IR, NMR and elemental analysis. All of these complexes have been proved to be efficient catalysts for the coupling reaction of CO and epoxides to obtain cyclic carbonates under solvent- and co-catalyst-free conditions.

Construction of Hollow CoO@ZnInS p-n Heterojunctions for Highly Efficient Photocatalytic Hydrogen Production.

Photocatalysts derived from semiconductor heterojunctions for water splitting have bright prospects in solar energy conversion. Here, a CoO@ZIS p-n heterojunction was successfully created by developing two-dimensional ZnInS on ZIF-67-derived hollow CoO nanocages, realizing efficient spatial separation of the electron-hole pair. Moreover, the black hollow structure of CoO considerably increases the range of light absorption and the light utilization efficiency of the heterojunction avoids the agglomeration of ZnInS nanosheets and further improves the hydrogen generation rate of the material.

Solvent-Free Coupling Reaction of Carbon Dioxide and Epoxides Catalyzed by Quaternary Ammonium Functionalized Schiff Base Metal Complexes under Mild Conditions.

A series of bifunctional Schiff base metal catalysts (Zn-NPClR, Zn-NPXH, and M-NPClH) with two quaternary ammonium groups were prepared for carbon dioxide (CO) and epoxide coupling reactions. The effects of the reaction variables on the catalytic activity were systematically investigated, and the optimal reaction conditions (120 °C, 1 MPa CO, 3 h) were screened. The performances of different metal-centered catalysts were evaluated, and Co-NPClH showed excellent activity.

α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila.

Posttranslational modification of tubulin increases the dynamic complexity and functional diversity of microtubules. Acetylation of α-tubulin at Lys-40 is a highly conserved posttranslational modification that has been shown to improve the flexibility and resilience of microtubules. Here we studied the in vivo functions of α-tubulin acetylation by knocking-out Atat, the Drosophila α-tubulin acetyltransferase, and by mutating Lys-40 to Arg in α1-tubulin.

DOT1L promotes cell proliferation and invasion by epigenetically regulating STAT5B in renal cell carcinoma.

DOT1L, the only histone H3 lysine 79 methyltransferase, has a prominent effect on promoting the progression of various malignancies, yet the functional contribution of DOT1L to renal cell carcinoma (RCC) progression remains unclear. DOT1L is overexpressed in RCC and linked to poor clinical outcomes. Chemical (SGC0946) or genetic suppression of DOT1L attenuates the growth and invasion of renal cancer cells and results in S-phase arrest.