Effect of Sugarcane Polyphenol Extract on α-Amylase Inhibition and Mechanism Exploration.

Although α-amylase is crucial for postprandial glucose control, existing inhibitors present various side effects, necessitating the exploration of natural alternatives. The ability of sugarcane polyphenol (SP) to inhibit α-amylase remains unclear. This study assessed the inhibitory activity of SP via in vitro assays, circular dichroism (CD), fluorescence quenching, and stability analysis, while the mechanism of action was elucidated using molecular docking and molecular dynamics (MD).

Alternation in sequence features and their influence on the anti-inflammatory activity of soy peptides during digestion and absorption in different enzymatic hydrolysis conditions.

This study investigated the anti-inflammatory properties and sequence variations of soy peptides during simulated digestion and absorption. Results showed that 500 Da peptides with N-terminal Leu, Ile, and Tyr exhibited enhanced intestinal transport, while the absorbed peptides in the Bromelain + Flavourzyme group (SIA-BF) demonstrated the strongest anti-inflammatory activity by inhibiting IκB phosphorylation. Mass spectrometry revealed that SIA-BF peptides were rich in branched-chain amino acids at the N-terminus and basic amino acids at the C-terminus.

Statistical Characterization of Food-Derived α-Amylase Inhibitory Peptides: Computer Simulation and Partial Least Squares Regression Analysis.

α-Amylase inhibitory peptides are used to treat diabetes, but few studies have statistically characterized their interaction with α-amylase. This study performed the molecular docking of α-amylase with inhibitory peptides from published papers. The key sites, side chain chargeability, and hydrogen bond distribution characteristics were analyzed.

The Formation, Structural Characteristics, Absorption Pathways and Bioavailability of Calcium-Peptide Chelates.

Calcium is one of the most important mineral elements in the human body and is closely related to the maintenance of human health. To prevent calcium deficiency, various calcium supplements have been developed, but their application tends to be limited by low calcium content and highly irritating effects on the stomach, among other side effects. Recently, calcium-peptide chelates, which have excellent stability and are easily absorbed, have received attention as an alternative emerging calcium supplement.

Anti-Inflammatory Function of Plant-Derived Bioactive Peptides: A Review.

Inflammation is considered to be a crucial factor in the development of chronic diseases, eight of which were listed among the top ten causes of death worldwide in the World Health Organization's World Health Statistics 2019. Moreover, traditional drugs for inflammation are often linked to undesirable side effects. As gentler alternatives to traditional anti-inflammatory drugs, plant-derived bioactive peptides have been shown to be effective interventions against various chronic diseases, including Alzheimer's disease, cardiovascular disease and cancer.