The role of circadian rhythm-related genes in type 2 diabetes from a multi-omics perspective.

Background: Recent studies have established a connection between circadian rhythm disruption and the development of type 2 diabetes mellitus (T2DM), yet the underlying genetic mechanisms remain inadequately understood. This research aims to elucidate the causal relationships between circadian rhythm-related genes and T2DM by utilising a multi-omics approach.

Methods: The study employed the GeneCards database to identify genes associated with circadian rhythms.

Long-Term Rotary Tillage and Straw Mulching Enhance Dry Matter Production, Yield, and Water Use Efficiency of Wheat in a Rain-Fed Wheat-Soybean Double Cropping System.

Water deficiency and low water use efficiency severely constrain wheat yield in dryland regions. This study aimed to identify suitable tillage methods and straw management to improve dry matter production, grain yield, and water use efficiency of wheat in the dryland winter wheat-summer bean (hereafter referred to as wheat-soybean) double-cropping system. A long-term located field experiment (onset in October 2009) with two tillage methods-plowing (PT) and rotary tillage (RT)-and two straw management-no straw mulching (NS) and straw mulching (SM)-was conducted at a typical dryland in China.

Synergistic Regulation of Pigment Cell Precursors' Differentiation and Migration by and in Nile Tilapia.

The evolutionary loss of in specific vertebrate lineages, such as mammals and cypriniform fish, raises fundamental questions about its functional necessity and potential redundancy or synergy with paralogous endothelin receptors in pigment cell development. In teleosts possessing both and (e.g.

Knowledge, attitudes, and practices among patients with diabetic foot ulcers towards disease management.

This study aimed to assess the knowledge, attitudes and practices (KAP) among patients with diabetic foot ulcers toward disease management. This web-based cross-sectional study was conducted between April and December 2023 at the Zhangzhou Affiliated Hospital of Fujian Medical University. Patients diagnosed with diabetic foot ulcers were invited to participate.

Correlation between orthostatic intolerance in children and levels of ACE2-Ang(1-7)-Mas axis and vitamin D.

Objective: To explore the correlation between orthostatic intolerance in children and levels of the ACE2-Ang(1-7)-Mas axis and vitamin D.

Methods: Blood samples were collected from 84 children with orthostatic intolerance and 307 healthy controls. After matching for age and sex, 84 children from each group were studied.

Integrating shear wave elastography into clinical prediction of Graves' disease recurrence: a novel risk scoring system.

Objective: This study aims to evaluate the utility of shear wave elastography (SWE) in predicting the recurrence risk of Graves' disease(GD), to construct a recurrence risk prediction model that integrates SWE and clinical characteristics, and to develop a risk scoring system aimed at enhancing the survival rate of patients with GD following drug treatment and prognosis management.

Methods: A prospective cohort study was conducted involving with 169 patients diagnosed with first-episode GD. By analyzing SWE parameters, three-dimensional thyroid volume, TRAb levels, and other clinical indicators, the Cox proportional hazards model was used to construct a recurrence risk prediction model for GD.

Carotenoids, instead of pteridines, determine color of xanthophores and erythrophores in tilapia.

There has been controversy over whether the chromogenic substances of xanthophores and erythrophores are pteridines or carotenoids in fish. In this study, we first extracted and quantified carotenoids and pteridines from erythrophores and xanthophores in tilapia, respectively. The results showed that the carotenoids and pteridines in erythrophores were significantly higher than those of xanthophores, and the carotenoids were significantly higher than the pteridines in both types of cells.

Subsoiling Before Wheat Sowing Enhances Grain Yield and Water Use Efficiency of Maize in Dryland Winter Wheat and Summer Maize Double Cropping System Under One-Off Irrigation Practice During the Wheat Season.

The winter wheat and summer maize double cropping system is the primary cropping pattern for wheat and maize in dryland areas of China. The management of tillage in this system is typically conducted before wheat sowing. However, few studies have validated and quantified the impact of tillage methods before wheat sowing and irrigation practices during the wheat season on the yield formation and water use efficiency of summer maize.

Experimental study on anti-slip performance of galvanized cable-clamped joint at elevated temperature.

Cable structures are widely used in large-span constructions due to their flexible shapes, high strength, and lightweight. However, the high-temperature performance of cable-clamped joints affects the overall fire resistance of cable structures. Moreover, the galvanized layer of cable may melt at high temperatures, which decreases the anti-slip capacity.

Elevated Fasting C-Peptide Levels Correlate with Increased 10-Year Risk of Atherosclerotic Cardiovascular Disease in Newly Diagnosed Type 2 Diabetes Patients.

Purpose: This study aims to analyze the impact of serum C-peptide levels in patients with newly diagnosed type 2 diabetes (T2DM) on the 10-year risk of atherosclerotic cardiovascular disease (ASCVD).

Patients And Methods: A total of 1923 patients with newly diagnosed T2DM were selected and categorized into four groups based on the interquartile range of fasting C-peptide (FCP) levels: Q1 group (FCP≤0.568 ng/mL), Q2 group (0.

One-Off Irrigation Combined Subsoiling and Nitrogen Management Enhances Wheat Grain Yield by Optimizing Physiological Characteristics in Leaves in Dryland Regions.

Irrigation practice, tillage method, and nitrogen (N) management are the three most important agronomic measures for wheat ( L.) production, but the combined effects on grain yield and wheat physiological characteristics are still poorly understood. We conducted a three-year split-split field experiment at the junction of the Loess Plateau and Huang-Huai-Hai Plain in China.

Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus.

Background: Cystic echinococcosis (CE) is a zoonotic disease caused by the larval stage of the dog tapeworm Echinococcus granulosus sensu lato (E. granulosus), with a worldwide distribution. The current treatment strategy for CE is insufficient.

Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and Study.

Background: Cadmium (Cd) is a highly toxic and widespread environmental oxidative stressor that causes a myriad of health problems, including osteoporosis and bone damage. Although nuclear factor erythroid 2-related factor 2 (NRF2) and its Cap 'n' Collar and basic region Leucine Zipper (CNC-bZIP) family member nuclear factor erythroid 2-related factor 1 (NRF1) coordinate various stress responses by regulating the transcription of a variety of antioxidant and cytoprotective genes, they play distinct roles in bone metabolism and remodeling. However, the precise roles of both transcription factors in bone loss induced by prolonged Cd exposure remain unclear.

Coupled one-off alternate furrow irrigation with nitrogen topdressing at jointing optimizes soil nitrate-N distribution and wheat nitrogen productivity in dryland.

The judicious management of water and nitrogen (N) is pivotal for augmenting crop productivity and N use efficiency, while also mitigating environmental concerns. With the advent of the High-Farmland Construction Program in China, one-off irrigation has become feasible for most dryland fields, presenting a novel opportunity to explore the synergistic strategies of water and N management. This study delves into the impact of one-off alternate furrow irrigation (AFI) and topdressing N fertilizer (TN) on soil nitrate-N distribution, and N productivity-including plant N accumulation, translocation, and allocation, and grain yield, protein content, N use efficiency of winter wheat (Triticum aestivum L.

Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.

Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antioxidants and reactive oxygen species (ROS) levels, especially the cytoplasmic and mitochondrial ROS during osteoclastogenesis in vitro. In the current study, we found that the absence of promotes osteoclast differentiation in bone-marrow-derived macrophages (BMMs) and RAW 264.

A comprehensive review on enzymatic biodegradation of polyethylene terephthalate.

Polyethylene terephthalate (PET) is a polymer synthesized via the dehydration and condensation reaction between ethylene glycol and terephthalic acid. PET has emerged as one of the most extensively employed plastic materials due to its exceptional plasticity and durability. Nevertheless, PET has a complex structure and is extremely difficult to degrade in nature, causing severe pollution to the global ecological environment and posing a threat to human health.

Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.

Background: Polymyalgia rheumatica (PMR) is a common inflammatory disease in elderly persons whose mechanism of pathogenesis has not been elucidated. Glucocorticoids are the main first-line treatments but result in numerous side effects. Therefore, there is a need to explore pathogenetic factors and identify possible glucocorticoid-sparing agents.

A novel germline frameshift mutation in the MLH1 gene in a patient with Lynch syndrome.

Lynch syndrome (LS) is an autosomal dominant inherited disorder, characterized by a predisposition to various cancers, mainly colorectal cancer (CRC). LS is caused by germline mutations in DNA mismatch repair genes i.e.

Elderly-onset rheumatoid arthritis vs. polymyalgia rheumatica: Differences in pathogenesis.

Rheumatoid arthritis is a chronic autoimmune disease that mainly affects the facet joints. Elderly-onset rheumatoid arthritis appears to exhibit symptoms similar to those of polymyalgia rheumatica, characterized by morning stiffness and pain in the shoulder and hip joints. Both diseases develop in the elderly, and it is sometimes challenging to distinguish them.

CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners.

Fine-tuning of osteoclast differentiation (OD) and bone remodeling is crucial for bone homeostasis. Dissecting the mechanisms regulating osteoclastogenesis is fundamental to understanding the pathogenesis of various bone disorders including osteoporosis and arthritis. Nuclear factor erythroid 2-related factor 1 (NFE2L1, also known as NRF1), which belongs to the CNC-bZIP family of transcription factors, orchestrates a variety of physiological processes and stress responses.

A combination of methylation and protein markers is capable of detecting gastric cancer detection by combined markers.

This study aimed to validate a combination of , and CA724 for gastric cancer (GC) detection. The performance of , and CA724 was examined in a prospective cohort study with 518 participants (151 with GC, 56 with atrophic gastritis, 87 with other gastrointestinal diseases and 224 with no evidence of disease). , or CA724 alone detected 48.