Characterization and antimicrobial activity of a novel lytic phage vB_SmaS_QH16 against : , , and biofilm studies.

Background: , an important opportunistic pathogen resistant to multiple antibiotics, necessitates alternative therapies. Phages, with their high specificity and bacteriolytic ability, are emerging as promising antibiotic alternatives. This study aimed to isolate and characterize a novel lytic phage targeting and to evaluate its antibacterial potential.

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy.

Efficient modulation of pivotal immune-regulatory molecules to leverage the tumor microenvironment (TME) and enhance therapeutic effects remains an ideal yet challenging goal. TGFβ1 represents a critical therapeutic target as a key cytokine involved in immune suppression and tumor progression. Here, a DNA origami-based framework functionalized with anti-TGFβ1 aptamers is developed to act as a captor for efficient TGFβ1 sequestration and fast clearance, thereby improving anti-tumor immunity.

Evolutionary dynamics and research hotspots of phage applications against infections from the past to the new era.

Background: is a common hospital pathogen that poses a serious clinical challenge due to its rapidly increasing resistance to antibiotics. Phage therapy has been successfully used to treat antibiotic resistant infections. The aim of this study was to comprehensively assess the current status and trend of research on the application of phages in infections through bibliometric analysis.

Medigap Regulations Provide Protections For Beneficiaries, Especially After Health Shocks, But May Raise Premiums.

Regulations for guaranteed issue and community rating for Medigap (supplemental) plans protect Medicare beneficiaries who want to leave the Medicare Advantage program from medical underwriting. These regulations, adopted in a handful of states, may be particularly valuable for beneficiaries with health shocks, defined as being newly diagnosed with a serious illness. Using a 20 percent random sample of Medicare beneficiaries from the period 2015-19, we found that disenrollment by those with health shocks was 2.

Characterization of the novel cross-genus phage vB_SmaS_QH3 and evaluation of its antibacterial efficacy against .

Background: Bacteriophages, which are natural bacterial predators, demonstrate potential as safe and effective biological control agents against drug-resistant infections. This study aims to characterize the biological properties of the novel lytic phage vB_SmaS_QH3 and comprehensively evaluate its efficacy in preventing and controlling clinically multidrug resistance infections using both and models.

Methods: The phage was isolated from hospital sewage using the multidrug resistant no.

Therapeutic potential of isochlorogenic acid A from in improving immune response and enhancing the efficacy of PD-1/PD-L1 blockade in triple-negative breast cancer.

Introduction: , a traditional medicinal herb, has garnered significant attention for its potential role in the prevention and treatment of breast cancer. Although clinical recognition of its efficacy has gradually increased, research has shown that contains a variety of chemical components, including triterpenes, carbohydrates, flavonoids, phenolic acids, sesquiterpenes, coumarins, fatty acids, and organic acids. However, the pharmacological mechanisms underlying 's effects and the identification of its key bioactive components warrant further investigation.

Angelicin ameliorated ulcerative colitis through activating HDAC1-derived HIF-1α acetylation.

Background: Ulcerative colitis (UC) is a stubborn disease that occurs globally. SSP-TXYF is a traditional Chinese medicine (TCM) compound, which is widely used in the treatment of UC, but its picking and preparation is complicated. Therefore, this work analyzes the components of SSP-TXYF to find an natural compound that can treat UC, and verifies its efficacy and mechanism, aiming to explore new natural compound with the same efficacy as SSP-TXYF.

Role of skin-homing t-cells in recurrent episodes of atopic dermatitis: a review.

Atopic dermatitis (AD) is a chronic relapsing disease with complex pathogenesis. Among them, inflammation is one of the primary pathogenesis of AD. AD is characterized by infiltration of lymphocytes into the skin's dermis, and the skin homing of lymphocytes plays an essential role in the recurrence of AD.

Targeting NANOS1 in triple-negative breast cancer: synergistic effects of digoxin and PD-1 inhibitors in modulating the tumor immune microenvironment.

Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer resistant to endocrine and targeted therapies. Immune checkpoint inhibitors (ICIs) have shown significant efficacy in various cancers. , commonly known as dandelion, has traditionally been used to treat breast-related diseases and is recognized for its beneficial composition and low side effects.

Silent threats of lead-based paints in toys and households to children's health and development.

Lead (Pb), a highly toxic heavy metal, poses a significant global health risk, particularly to children. Widely used in paint manufacturing for its remarkable corrosion-resistance properties Pb exposure has been linked to severe health issues, including reduced neurotransmitter levels, organ damage, potentially leading to death in extreme cases. Children Are particularly vulnerable, with Pb toxicity primarily affecting the brain, reproductive, kidneys, and cardiovascular systems.

Immunomodulatory potential of primary cilia in the skin.

Primary cilia (PC) are essential signaling hubs for proper epithelial formation and the maintenance of skin homeostasis. Found on most cells in the human body, including skin cells, PC facilitate signal transduction that allows ciliated cells to interact with the immune system via multiple pathways, helping to maintain immune system homeostasis. PC can be altered by various microenvironmental stimuli to develop corresponding regulatory functions.

Sishen Pill & Tongxieyaofang ameliorated ulcerative colitis through the activation of HIF-1α acetylation by gut microbiota-derived propionate and butyrate.

Background: Ulcerative colitis (UC) is a chronic inflammatory bowel disease closely related to gut microbiota dysbiosis and intestinal homeostasis imbalance. Sishen Pill&Tongxieyaofang (SSP-TXYF) has a long history of application in traditional Chinese medicine and is widely used in UC clinics. However, its mechanism of action is still unclear.

Screening of the Candidate Metabolite to Evaluate the Mycelium Physiological Maturation of Based on Metabolome and Transcriptome Analysis.

is a commercially cultivated rare edible mushroom with high dietary and medicinal value. The mycelium physiological maturation was an important factor to the yield and quality of mushrooms obtained. However, it was impossible to obtain discriminative characteristics represented the maturity level of the mycelia from morphological features.

Knowledge, attitude and practice of pediatric healthcare staff towards the therapy for patients with congenital heart disease.

Background: This study aimed to investigate the knowledge, attitude and practice (KAP) of pediatric healthcare staff towards the therapy for patients with congenital heart disease (CHD). CHD is a major global health concern, posing significant risks to health and life despite advancements in early detection and treatment.

Methods: This web-based cross-sectional study was conducted from May 04, 2023 to August 12, 2023 in the Bengbu area (three counties and one city) for pediatric healthcare staff.

Altered gut metabolites and metabolic reprogramming involved in the pathogenesis of colitis-associated colorectal cancer and the transition of colon "inflammation to cancer".

Colitis-associated colorectal cancer (CAC) is fatal and can develop spontaneously or as a complication of inflammatory bowel diseases. Although co-administration of azoxymethane/dextran sulfate sodium (AOM/DSS) is a classic method for CAC modeling, its limitations need to be addressed. Accordingly, we aimed to optimize the AOM/DSS model to study CAC extensively and further investigate its pathogenic mechanisms relative to microbiota and metabolism.

Short- and mid-term outcomes of the aortic root repair versus root replacement in acute type A aortic dissection.

Background: In patients with acute acute type A aortic dissection (ATAAD) requiring emergency surgery, the use of aortic root repair or replacement remains a topic of controversy. The purpose of this study was to evaluate the early and mid-term clinical outcomes after aortic root repair or replacement, and to provide a theoretical basis for such patients.

Methods: The study included 442 consecutive patients with ATAAD who underwent aortic root repair [n=227, repair group (RG)] or the Bentall procedure [n=215, Bentall group (BG)] at our hospital between December 2018 and December 2021.

Impact of fermentation by Saccharomyces Cerevisiae on the macronutrient and in vitro digestion characteristics of Chinese noodles.

This study examined the impact of live bread yeast (Saccharomyces cerevisiae) on the nutritional characteristics of Asian dried noodles. Micronutrient analysis of fermented noodles revealed a 6.9% increase in the overall amino acid content, a 37.

GDF15 attenuates sepsis-induced myocardial dysfunction by inhibiting cardiomyocytes ferroptosis via the SOCS1/GPX4 signaling pathway.

Sepsis is a systemic inflammatory response syndrome triggered by infection, presenting with symptoms such as fever, increased heart rate, and low blood pressure. In severe cases, it can lead to multiple organ dysfunction, posing a life-threatening risk. Sepsis-induced cardiomyopathy (SIC) is a critical factor in the poor prognosis of septic patients, leading to myocardial dysfunction characterized by cell death, inflammation, and diminished cardiac function.

Assessment of Pelvic Tilt in Anteroposterior Radiographs by Area Ratio Based on Deep Learning.

Study Design: Diagnostics.

Objectives: Based on deep learning semantic segmentation model, we sought to assess pelvic tilt by area ratio of the lesser pelvic and the obturator foramen in anteroposterior (AP) radiographs.

Background: Pelvic tilt is a critical factor in hip and spinal surgery, commonly evaluated by medical professionals through sagittal pelvic radiographs.

Targeting optimal power consumption: Optimizing operational parameters for orchard furrowing and fertilizing machine.

In response to the problem of excessive power consumption during the furrowing operation of orchard furrowing fertilizer machines, an optimization experiment of furrowing operation parameters for orchard furrowing fertilizer machine was conducted based on discrete element simulations. This research focused on the impact of furrowing device operation parameters on furrowing power consumption under full machine operating conditions. Firstly, a kinematics analysis of the soil granules during cutting was done.

Clinical implications of respiratory ciliary dysfunction in heterotaxy patients with congenital heart disease: elevated risk of postoperative airway complications.

Objective: Cardiac surgery in Congenital Heart Disease-Heterotaxy (CHD-HTX) patients often leads to increased postoperative airway complications. Abnormal respiratory ciliary function, resembling primary ciliary dyskinesia, has been observed. We expanded the sample size by retrospectively reviewing Ciliary Dysfunction (CD) in CHD-HTX patients to verify the increased risk of post-surgical respiratory complications.

The role of primary cilia in thyroid diseases.

Primary cilia (PC) are non-motile and microtube-based organelles protruding from the surface of almost all thyroid follicle cells. They maintain homeostasis in thyrocytes and loss of PC can result in diverse thyroid diseases. The dysfunction of structure and function of PC are found in many patients with common thyroid diseases.

Integrative analysis reveals chemokines CCL2 and CXCL5 mediated shear stress-induced aortic dissection formation.

Background: Aortic dissection (AD) is a critical emergency in cardiovascular disease. AD occurs only in specific sites of the aorta, and the variation of shear stress in different aortic segments is a possible cause not reported. This study investigated the key molecules involved in shear stress-induced AD through quantitative bioinformatic analysis of a public RNA sequencing database and clinical tissue sample validation.

AdaSAM: Boosting sharpness-aware minimization with adaptive learning rate and momentum for training deep neural networks.

Sharpness aware minimization (SAM) optimizer has been extensively explored as it can generalize better for training deep neural networks via introducing extra perturbation steps to flatten the landscape of deep learning models. Integrating SAM with adaptive learning rate and momentum acceleration, dubbed AdaSAM, has already been explored empirically to train large-scale deep neural networks without theoretical guarantee due to the triple difficulties in analyzing the coupled perturbation step, adaptive learning rate and momentum step. In this paper, we try to analyze the convergence rate of AdaSAM in the stochastic non-convex setting.