Lactate Promotes Collagen Expression, Proliferation, and Migration through H3K18 Lactylation-Dependent Stimulation of LTBP3/TGF-β1 Axis in Keloid Fibroblasts.

Keloids are fibroproliferative dermal lesions characterized by unrestrained fibroblast proliferation, collagen overproduction, and persistent enlargement. Lactate has been suggested to regulate keloid fibroblast activity, although the underlying mechanism remains unclear. Histone lactylation is an important epigenetic regulatory mechanism through which lactate regulates pathophysiological processes, but its role in keloids remains to be studied.

Construction and Validation of a Model for Predicting Fear of Childbirth: A Cross-Sectional Population Study via Machine Learning.

Background: Fear of childbirth (FOC) is a psychological state of fear and distress that pregnant women experience when they approach labor. This fear can have significant negative effects on both the mother and the newborn, making it crucial to study the influencing factors of FOC to implement early interventions.

Objective: First, identify the risk factors for FOC occurrence, then construct a predictive model for FOC and evaluate its predictive efficiency.

Infertility-related stress is associated with quality of life through negative emotions among infertile outpatients.

Infertility is not a fatal disease but it really produces infertility-related stress and affects individuals' quality of life to a great extent. This study aims to investigate the relations among infertility-related stress, negative emotions and quality of life in infertile outpatients, and suppose gender difference as well as Dark Triad, which contained three dark personality traits: Machiavellianism, narcissism, and psychopathy, would moderate the relations. 105 infertile outpatients age range 20-49 completed a cross-sectional questionnaire on the Fertility Quality of Life scale, the Fertility Problem Inventory, the Hospital Anxiety and Depression Scale a the Chinese version of Dirty Dozen.

The role of core self-evaluation between peer victimization and depression: A longitudinal multilevel moderated mediation model and the healthy context paradox in Chinese adolescents.

Background: According to the healthy context paradox, the negative effects of peer victimization on core self-evaluation and depressive symptoms may vary in different levels of classroom-level victimization. However, previous studies have not investigated this issue using a longitudinal study design.

Objective: The present study used a longitudinal design to examine why and under what conditions peer victimization was associated with adolescents' depressive symptoms.

Childhood maltreatment and Internet addiction among Chinese adolescents: A moderated mediation model.

Although childhood maltreatment has been suggested to play an important role in developing Internet addiction among adolescents, little is known about the mediating and moderating mechanisms underlying this association. The present study investigated (a) the mediating role of maladaptive cognitive emotion regulation strategy (MCERS) in the association between childhood maltreatment and Internet addiction, and (b) the moderating role of peer support in the relationship between childhood maltreatment and Internet addiction. A sample of 4163 Chinese adolescents (50.

Achieving smartphone-based colorimetric assay for Hg with a bimetallic site strategy based on Hg-triggered oxidase-like catalytic activity of NSC/CoNiS nanocomposite.

Modulation of the nanozyme's catalytic activity is crucial for its real applications in detecting target analytes. Herein, we fabricated the nanocomposite (NSC/CoNiS) of N, S co-doped carbon and CoNiS by a facile sol-gel approach. Compared to NSC/NiS, NSC/CoNiS with bimetallic active sites displayed better enzyme-mimetic activity.

[Recent advances in the development and application of effervescence-assisted microextraction techniques].

Effervescence-assisted microextraction (EAM) is a novel sample pretreatment method based on the reaction of CO and H donors to generate CO bubbles and promote rapid dispersion of the extractant. During this process, the unique dispersion method increases the contact area between the target molecule and the extraction solvent, and the adsorption/extraction efficiency of the adsorbent/extractant toward the target molecule is also enhanced. The EAM technique is of particular interest due its convenient application, low running costs, reduced solvent consumption, high extraction efficiency, and environmental friendliness.

The association of childhood maltreatment with Internet addiction: the serial mediating effects of cognitive emotion regulation strategies and depression.

Objectives: Childhood maltreatment, cognitive emotion regulation strategies (CERSs), and depression can be important in adolescents' Internet addiction. The current study aims to investigate the direct effect of childhood maltreatment on Internet addiction and its indirect effects via CERSs and depression.

Participants And Setting: 4091 adolescents (age M = 13.

Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids.

Keloids represent a fibrotic disorder characterized by the excessive deposition of extracellular matrix (ECM). However, the mechanisms through which ECM deposition in keloids is regulated remain elusive. In this study, we found that the expression of both TWEAK and its cognate receptor Fn14 was significantly downregulated in keloids and that TWEAK/Fn14 signaling repressed the expression of ECM-related genes in keloid fibroblasts.

[Risk Assessment Method of Non-point Source Pollution Output for Watershed Using High Resolution Data].

In recent years, non-point source pollution has become the main cause of water quality deterioration in some reservoirs in China. Taking the Panjiakou Reservoir as an example, the classical output risk model was improved by introducing a precipitation factor and terrain factor. Combined with high-resolution satellite precipitation products (GPM) and GF-6 satellite images, a high-resolution data-driven risk assessment method for non-point source pollution output was established to study the temporal and spatial distribution characteristics of non-point source pollution output risk in the Panjiakou Reservoir basin.

TSP1 promotes fibroblast proliferation and extracellular matrix deposition via the IL6/JAK2/STAT3 signalling pathway in keloids.

Keloids are benign fibroproliferative diseases with abnormally proliferated bulges beyond the edge of the skin lesions, and they are characterized by uncontrolled fibroblast proliferation and excessive extracellular matrix deposition in the dermis. However, the definite mechanisms that increase fibroblast proliferation and collagen deposition in keloids remain unclear. Thrombospondin 1 (TSP1) has been suggested to play an important role in wound healing and fibrotic disorders, but its role in keloids is unknown.

Efficacy and Safety of Programmed Cell Death 1 Inhibitor Monotherapy Versus Chemotherapy as Second-Line Treatment for Advanced Esophageal Cancer: A Meta-analysis and Systematic Review.

Purpose: With programmed cell death 1 (PD-1) inhibitors approved for second-line treatment of advanced esophageal cancer, immunotherapy and chemotherapy have gradually become the main treatments for second-line treatment of patients with advanced esophageal cancer (AEC). This meta-analysis and systematic review were conducted to evaluate the efficacy and safety of PD-1 inhibitors monotherapy versus chemotherapy in second-line treatment of AEC.

Methods: Eligible randomized controlled trials were searched in PubMed, Embase, and the Cochrane Library and abstracts presented at the American Society of Clinical Oncology or European Society of Medical Oncology were reviewed to assess the efficacy and tolerability of PD-1/programmed cell death ligand 1 (PD-L1) inhibitors relative to chemotherapy for AEC from January 2016 to October 2020.

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases.

Fibrotic skin disease represents a major global healthcare burden, characterized by fibroblast hyperproliferation and excessive accumulation of extracellular matrix. Fibroblasts are found to be heterogeneous in multiple fibrotic diseases, but fibroblast heterogeneity in fibrotic skin diseases is not well characterized. In this study, we explore fibroblast heterogeneity in keloid, a paradigm of fibrotic skin diseases, by using single-cell RNA-seq.

Comparative efficacy and safety of PD-1/PD-L1 Inhibitors versus platinum-based chemotherapy for the first-line treatment of advanced non-small cell lung cancer: a meta analysis of randomized controlled trials.

Objective: The main aim of this study was to systematically evaluate the efficacy and safety of inhibitors of programmed cell death receptor 1 (PD-1) and its ligand, programmed cell death ligand-1 (PD-L1), in the treatment of advanced non-small cell lung cancer (NSCLC).

Methods: Randomized controlled trials assessing the efficacy of PD-1/PD-L1 inhibitors relative to platinum-based chemotherapy for advanced NSCLC in PubMed, EMBASE, and Cochrane libraries from 2015 to 2020 were searched, along with review of studies at American Society of Clinical Oncology (ASCO) and European society for Medical Oncology (ESMO). Pooled hazard ratios (HR) for progression-free survival (PFS) and overall survival (OS) and odds ratios (OR) for adverse events (AE) were calculated using STATA and Revman software.

Asymmetry of Cerebral Peduncles for Predicting Motor Function Restoration in Young Patients Before Hemispherectomy.

Objective: Hemispherectomy has been used successfully for patients with medically intractable epilepsy. However, it is difficult to predict postoperative motor function. The aim of the present study was to analyze whether the preoperative asymmetry of cerebral peduncles could be used to predict motor function restoration before hemispherectomy for young patients with medically intractable epilepsy.

Carboxylate-functionalized sugarcane bagasse as an effective and renewable adsorbent to remove methylene blue.

This study prepared a carboxylate-functionalized sugarcane bagasse (CF-SCB) from sugarcane bagasse (SCB) via a simple and low-toxicity chemical modification to enhance its capacity for adsorbing methylene blue (MB) from aqueous solutions. The success of chemical modification was confirmed by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), the pore area and porosity, and zeta potential measurement analysis. The adsorption capacity of CF-SCB was investigated at different pHs, ionic strengths, temperatures, contact times and initial dye concentrations.

[The effect of periodontal initial therapy on chronic periodontitis and subgingival periodontal pathogen].

Purpose: To evaluate the effect of periodontal initial therapy on clinical parameters and subgingival periodontal pathogen in patients with chronic periodontitis.

Methods: One hundred and twenty patients with chronic periodontitis were included. Probing depth (PD), attachment loss (AL), plaque index (PLI) and gingival index (GI) were evaluated at baseline and after-initial therapy.

[A study on the mechanism of copper-induced resistance to potato virus Y-vein necrosis strain (PVY(N)) in tobacco].

In order to reveal the induced resistance mechanism of tobacco treated with copper solution to potato virus Y-vein necrosis strain (PVY(N)), disease indexes, contents of virus and some physiological and biochemical indexes in tobacco were studied. The results showed that when treated at the copper concentration of 0.8 mg x L(-1), the symptom displayed and vein necrosis on tobacco were postponed, the disease index and content of virus sharply decreased , and the content of chlorophyll a, chlorophyll b and phenylalanine ammonia lyase (PAL) activity remarkably increased.

[A study on the state of periodontal health of 400 professional adults by random sampling in Shanghai].

Purpose: To investigate and analyze the state of periodontal health of 400 adults at their post and risk factors in Shanghai.

Methods: 400 subjects (249 male, 151 female), aged from 25 to 59, were requested to fill a questionnaire. The probing depth (PD), clinical attachment level (CAL), tooth mobility (TM) and bleeding on probing(BOP) on 6 sites of each indicated tooth were measured and recorded.

[The relationship between the calcaneus density and the degree of inflammation in patients with generalized aggressive periodontitis].

Purpose: To evaluate the relationship between the calcaneus density and the degree of inflammation in patients with generalized aggressive periodontitis.

Methods: Thirty one volunteers with healthy periodontium (as control group) and 38 patients with generalized aggressive periodontitis (as experimental group) were involved in this study. The average ages of the two groups were 27 and 23 years respectively.