Anatomic-size determinants drive therapeutic decisions in inflammatory fibroid polyps: a retrospective study.

Objective: Inflammatory fibroid polyps (IFPs), uncommon benign growths in the gastrointestinal tract, currently lack standardized treatment protocols. Our investigation sought to determine crucial clinical indicators for therapeutic decision-making in IFP management.

Methods: We conducted a retrospective analysis of 114 hospitalized patients from The First Affiliated Hospital of Fujian Medical University and Fuzhou University Affiliated Provincial Hospital between January 2015 and April 2025.

Percutaneous versus Traditional Fixation for Fracture Patients with Ankylosing Spinal Disorders: A Meta-Analysis.

Objective: With the advancement of surgical technology and the refinement of minimally invasive techniques, the emergence of novel technologies has exerted a discernible impact on conventional approaches. Currently, percutaneous internal fixation guided by X-ray fluoroscopy has been employed in patients with ankylosing spondylitis and diffuse idiopathic skeletal hyperostosis, presenting a challenge to traditional open surgery. Our objective was to conduct a comprehensive literature review aiming to evaluate the potential surgical advantages associated with percutaneous internal fixation.

Bidirectional Phase Separation Spinning Under Natural Drying to Prepare Aerogel Fibers for Thermal Insulation.

Aerogel fibers have emerged as a promising solution in thermal insulation. Yet, the current preparation methods pose challenges: they are either inefficient for continuous production or involve energy-intensive and time-consuming steps like freeze-drying or supercritical drying, thus restricting their practical utility. Here, a bidirectional phase separation spinning technique is introduced for continuous and rapid production (360 m h) of aerogel fibers at any desired length.

Distinct T Cell Receptor Clonotypes in the Sardinian Population Highlight the Role of Mucosal-Associated Invariant T Cells and Invariant Natural Killer T Cells in Multiple Sclerosis.

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory disease of the central nervous system, driven by T-cell mediated immune responses. Studying T-cell receptor (TCR) clonotypes specific to MS in distinct populations can provide insights into disease mechanisms. The Sardinian population, with its unique genetic background resulting from geographical isolation, presents a high-risk cohort for MS research, offering a valuable context for understanding the disease's pathogenesis.

Ultrasonic Cavitation-Manipulated Macrophages Hitchhiking Augments Delivery of Nanocarriers for Active and Efficient Cancer Therapy.

Cell-derived vehicles have shown promise in drug delivery for cancer therapy, but they are hindered by lack of effective methods to release drug from cellular vehicles. To overcome this dilemma, this work develops nanodrug-hitchhiking macrophages (OGNLN@MACs) that can unload drugs under ultrasound irradiation. The OGNLN is perfluoropentane-loaded liposomal nanodroplet which consists of lipophilic prodrugs of elaidate-conjugated gemcitabine and NLG919.

Epithelial zinc finger protein in lung adenocarcinoma: prognostic biomarker with molecular and clinical implications.

Objective: This study aimed to evaluate the prognostic significance of epithelial zinc finger protein (EZF/KLF4) in lung adenocarcinoma (LAC) and explore its potential roles in tumor progression and immune regulation.

Methods And Materials: EZF expression and its associations with clinical characteristics were analyzed using TCGA and GEO datasets, and validated by immunohistochemistry in 25 paired LAC and adjacent normal tissues. Mechanistic insights were investigated through protein-protein interaction networks, gene set enrichment analysis (GSEA), DNA methylation profiling, and immune cell infiltration analysis via single-sample GSEA.

Photoactive metal-covalent organic framework nanozymes with enhanced peroxidase-mimicking activity for eliminating drug-resistant bacterial infections.

Nanozyme-mediated ferroptosis strategies present a promising approach for eliminating clinically prevalent superbugs. However, the catalytic efficiency of conventional nanozymes is frequently limited by pH variations and can lead to sustained substrate depletion, potentially inducing tissue inflammation. In this study, we introduce a photoactive copper-metalized single-atom covalent organic framework (CuSA-COF) nanozyme designed to efficiently initiate a nonferrous ferroptosis-like mechanism within bacterial cells.

Disulfidptosis, a novel regulated cell death to predict survival and therapeutic response in kidney renal clear cell carcinoma.

Background: Metabolic regulation of cell death has become a potential therapeutic target for kidney renal clear cell carcinoma (KIRC), which is distinguished by notable heterogeneity and significant immune infiltration. Disulfidptosis, a recently identified form of cell death, has gained prominence in antitumor immunity. This research aims to investigate the correlation between disulfidptosis and prognosis of KIRC, while also exploring the possibility of predicting therapeutic response by disulfidptosis-associated genes (DAGs).

Incorporation of Cu(I) Sites into Zeolite via a Controllable Reduction Strategy for Ethylene/Ethane Separation.

The development of effective adsorbents for efficient separation of ethylene (CH) and ethane (CH) is crucial for the petrochemical sector, yet this is still difficult because of their comparable molecule sizes and physical characteristics. Cu(I) could generate π-complexes with molecules containing unsaturated bonds, enabling Cu(I)-based adsorbents to selectively and efficiently separate CH from CH. However, the traditional autoreduction method typically requires extreme temperatures (≥700 °C) to convert Cu(II) to Cu(I), leading to high energy consumption.

Comparison of I-gel and Baska mask in elective surgery: a meta-analysis.

Objective: The supraglottic airway device is a viable alternative to tracheal intubation for elective surgery. To conduct a comparative analysis of the advantages and disadvantages associated with use of the Baska mask and I-gel across various dimensions.

Design: A comprehensive search was conducted across PubMed, Embase, Cochrane Library, Web of Science, and other relevant databases to identify randomised controlled trials (RCTs) involving patients who used the Baska mask and I-gel.

Renoprotective effects of dulaglutide, a GLP-1 agonist, involving regulation of epithelial-mesenchymal transition in patients with type 2 diabetes and diabetic kidney disease.

Aims: To assess the renoprotective effects of dulaglutide and identify mechanisms of action in patients with type 2 diabetes and diabetic kidney disease (DKD).

Materials And Methods: Outpatients/ambulant patients at the Department of Endocrinology, Affiliated Hospital of Xuzhou Medical University between October 2021 and July 2023, with type 2 diabetes and DKD, a urinary albumin-to-creatinine ratio (UACR) ≥ 3 mg/mmol and who were receiving hypoglycemic agents were prescribed dulaglutide at a dose rate of 0.75 - 1.

The roles of physical activity and sedentary behavior in the relationship between socioeconomic status and depressive symptoms: Observations from a national study.

Background: While the association between socioeconomic status (SES) and depression is well-documented, the relative contributions of physical activity (PA) and sedentary behavior (SB) to this association remain unclear. This study was to explore the effects of PA, SB in the associations between SES and depressive symptoms, respectively.

Methods: Our study included 15,906 adults (age≥20 years) from the National Health and Nutrition Examination Survey (NHANES), 2011-2020.

Targeting of TAMs: can we be more clever than cancer cells?

АBSTRACT: With increasing incidence and geography, cancer is one of the leading causes of death, reduced quality of life and disability worldwide. Principal progress in the development of new anticancer therapies, in improving the efficiency of immunotherapeutic tools, and in the personification of conventional therapies needs to consider cancer-specific and patient-specific programming of innate immunity. Intratumoral TAMs and their precursors, resident macrophages and monocytes, are principal regulators of tumor progression and therapy resistance.

Electric Field-Dependent Evolution Dynamics of Conductive Filaments in 2D Material-Based Planar Memristors.

2D materials have emerged as potential building blocks for electrochemical metallization (ECM) memristors with excellent performance. The evolution dynamics of conductive filaments (CFs) directly determine the resistance switching performance of the 2D material-based ECM memristors. However, achieving controllable CFs under the operation conditions remains challenging.

OsAAH confers salt tolerance in rice seedlings.

Soil salinization is becoming a great threat that reduces crop productivity worldwide. In this study, we found that rice allantoate amidohydrolase (OsAAH) expression was significantly upregulated by salt stress, and its overexpression conferred salt tolerance at the seedling stage. Compared to wild type (WT), the contents of ureides (allantoin and allantoate) were significantly increased in Osaah mutants and reduced in OsAAH overexpression lines both before and after salt treatments.

TIPE2 aggravates experimental colitis and disrupts intestinal epithelial barrier integrity by activating JAK2/STAT3/SOCS3 signal pathway.

Ulcerative colitis (UC) is a chronic relapsing and progressive inflammatory disease of the colon. TIPE2 is a negative regulator of innate and adaptive immunity that maintains immune homeostasis. We found that TIPE2 was highly expressed in mucosa of mice with colitis.

The prevalence and related factors of compassion fatigue among nursing interns: a cross-sectional study.

Background: Compassion fatigue is common among nurses and can lead to decreased motivation, impaired physical and mental health, and turnover. Nursing interns often face environments the same as professional nurses, yet their compassion fatigue has received less attention. Therefore, this study aims to assess the prevalence and related factors of compassion fatigue among nursing interns.

Pomalidomide in patients with multiple myeloma: potential impact on the reconstitution of a functional T-cell immunity.

Background: Pomalidomide, a third-generation oral immunomodulatory drug, exhibits efficacy in patients with relapsed multiple myeloma or those refractory to bortezomib and lenalidomide (RRMM).

Methods: In this clinical context, we employed flow cytometry and CDR3 spectratyping to monitor the dynamics of the T-cell repertoire during Pomalidomide treatment, aiming to investigate its potential to reverse the immunological abnormalities characteristic of RRMM.

Results: By flow cytometry at baseline we found a significant decrease in CD4 + frequency in MM patients, while CD8 + frequency were significantly higher in patients when compared to controls.

The associations of chronic pain and 24-h movement behaviors with incident mental disorders: evidence from a large-scale cohort study.

Background: Chronic pain was associated with a higher risk of mental disorders (e.g., depression and anxiety).

Exploring the Association between Cathepsin B and Parkinson's Disease.

Objective: The aim of this study is to investigate the association between Cathepsin B and Parkinson's Disease (PD), with a particular focus on determining the role of -acetylaspartate as a potential mediator.

Methods: We used summary-level data from Genome-Wide Association Studies (GWAS) for a two-sample Mendelian randomization (MR) analysis, exploring the association between Cathepsin B (3301 cases) and PD (4681 cases). A sequential two-step MR approach was applied (8148 cases) to study the role of -acetylaspartate.

Improving Soluble Phenolic Profile and Antioxidant Activity of Grape Pomace Seeds through Fungal Solid-State Fermentation.

Grape pomace seeds contain abundant phenolic compounds, which are also present in both soluble and insoluble forms, similar to many other plant matrices. To further increase the extractable soluble phenolics and their antioxidant activities, grape pomace seeds were fermented with different fungi. Results showed that solid-state fermentation (SSF) with , , and at 28 °C and 65% humidity had a significantly positive impact on the release of soluble phenolics in grape pomace seeds.