Bioengineering Living Biohybrid Therapeutics for Synergistic HS Gaseous-Photothermal Cancer Eradication.

Hydrogen sulfide (HS)-mediated gaseous therapies feature high therapeutic efficacy and biosafety in cancer treatment, but conventional HS delivery protocols suffer from poor tumor specificity and uncontrollable release. Here, a living therapeutic biohybrid is developed that integrates engineered microbes for in situ HS production with self-mineralized copper sulfide (CuS) nanoparticles, enabling synergistic HS gaseous-photothermal cancer treatment. These engineered facultative anaerobic bacteria Vibrio natriegens continuously produce HS and synthesize CuS nanoparticles, forming Bac@CuS living biohybrids that inhibit the mitochondrial electron transport chain through HS production, leading to increased reactive oxygen species production and subsequent apoptosis of cancer cells.

Resonantly Enhanced Hybrid Wannier-Mott-Frenkel Excitons in Organic-Inorganic Van Der Waals Heterostructures.

Hybrid excitons formed via resonant hybridization in 2D material heterostructures feature both large optical and electrical dipoles, providing a promising platform for many-body exciton physics and correlated electronic states. However, hybrid excitons at organic-inorganic interface combining the advantages of both Wannier-Mott and Frenkel excitons remain elusive. Here, hybrid excitons are reported in the copper phthalocyanine/molybdenum diselenide (CuPc/MoSe) heterostructure (HS) featuring strong molecular orientation dependence by low-temperature photoluminescence and absorption spectroscopy.

Living Therapeutics for Synergistic Hydrogen-Photothermal Cancer Treatment by Photosynthetic Bacteria.

Hydrogen gas (H) therapy, recognized for its inherent biosafety, holds significant promise as an anti-cancer strategy. However, the efficacy of H treatment modalities is compromised by their reliance on systemic gas administration or chemical reactions generation, which suffers from low efficiency, poor targeting, and suboptimal utilization. In this study, living therapeutics are employed using photosynthetic bacteria Rhodobacter sphaeroides for in situ H production combined with near-infrared (NIR) mediated photothermal therapy.

Hydrogels: a promising therapeutic platform for inflammatory skin diseases treatment.

Inflammatory skin diseases, such as psoriasis and atopic dermatitis, pose significant health challenges due to their long-lasting nature, potential for serious complications, and significant health risks, which requires treatments that are both effective and exhibit minimal side effects. Hydrogels offer an innovative solution due to their biocompatibility, tunability, controlled drug delivery capabilities, enhanced treatment adherence and minimized side effects risk. This review explores the mechanisms that guide the design of hydrogel therapeutic platforms from multiple perspectives, focusing on the components of hydrogels, their adjustable physical and chemical properties, and their interactions with cells and drugs to underscore their clinical potential.

Estimation of the distribution patterns of heavy metal in soil from airborne hyperspectral imagery based on spectral absorption characteristics.

Though soil is widely known as one of the most valuable resources for the world, its quality is going to be lower because of unsustainable economic development and social progress. Therefore, it is important for us to monitor and evaluate the quality of soil, especially its heavy metal contents which is too scarce to identify in soil spectra easily but poisonous enough to affect human health in a long run. Most of the existing estimation methods have based the characteristic bands on statistical analysis to a large extent, which is hard to accurately explain the retrieval mechanism.

Magnifying image-enhanced endoscopy-only mode boosted early cancer diagnostic efficiency: a multicenter randomized controlled trial.

Background And Aims: Magnifying image-enhanced endoscopy (MIEE) is an advanced endoscopy with image enhancement and magnification used in preoperative examination. However, its impact on the detection rate is unknown.

Methods: We conducted an open-label, randomized, parallel (1:1:1), controlled trial in 6 hospitals in China.

Lifetime over 10000 hours for organic solar cells with Ir/IrO electron-transporting layer.

The stability of organic solar cells is a key issue to promote practical applications. Herein, we demonstrate that the device performance of organic solar cells is enhanced by an Ir/IrO electron-transporting layer, benefiting from its suitable work function and heterogeneous distribution of surface energy in nanoscale. Notably, the champion Ir/IrO-based devices exhibit superior stabilities under shelf storing (T = 56696 h), thermal aging (T = 13920 h), and maximum power point tracking (T = 1058 h), compared to the ZnO-based devices.

Efficient Hot Electron Capture in CuPc/MoSe Heterostructure Assisted by Intersystem Crossing.

Efficient hot electron extraction is a promising approach to develop photovoltaic devices that exceed the Shockley-Queisser limit. However, experimental evidence of hot electron harvesting employing an organic-inorganic interface is still elusive. Here, we reveal the hot electron dynamics at a CuPc/MoSe interface using steady-state spectroscopy and transient absorption spectroscopy.

Tumor-Microenvironment-Responsive Cascade Reactions by a Cobalt-Single-Atom Nanozyme for Synergistic Nanocatalytic Chemotherapy.

Nanocatalytic therapy, involving the nanozyme-triggered production of reactive oxygen species (ROS) in the tumor microenvironment (TME), has demonstrated potential in tumor therapy, but nanozymes still face challenges of activity and specificity that compromise the therapeutic efficacy. Herein, we report a strategy based on a single-atom nanozyme to initiate cascade enzymatic reactions in the TME for tumor-specific treatment. The cobalt-single-atom nanozyme, with Co-N coordination on N-doped porous carbon (Co-SAs@NC), displays catalase-like activity that decomposes cellular endogenous H O to produce O , and subsequent oxidase-like activity that converts O into cytotoxic superoxide radicals to efficiently kill tumor cells.

RuO/rGO heterostructures as mimic peroxidases for colorimetric detection of glucose.

The successful synthesis of ruthenium oxide/reduced graphene oxide (RuO/rGO) heterostructures by one-pot hydrothermal method using graphene oxides and RuCl as precursors is reported. The heterostructures had high peroxidase-like (POD-like) activities, which catalyzes the oxidation of classical peroxidase substrate 3,3',5,5'-tetramethylbenzidine (TMB) in the presence of HO to create a blue colored reaction product. The catalytic activity was significantly enhanced by the synergistic effect between RuO nanoparticles and rGO.

Intercalated Gold Nanoparticle in 2D Palladium Nanosheet Avoiding CO Poisoning for Formate Production under a Wide Potential Window.

The electrochemical CO reduction into formate acid over Pd-based catalysts under a wide potential window is a challenging task; CO poisoning commonly occurring on the vulnerable surface of Pd must be overcome. Herein, we designed a two-dimensional (2D) AuNP-in-PdNS electrocatalyst, in which the Au nanoparticles are intercalated in Pd nanosheets, for formate production under a wide potential window from -0.1 to -0.

Synthesis of carbon quantum dots for application of alleviating amyloid-β mediated neurotoxicity.

Alzheimer's disease (AD) has been an intractable neurodegenerative disease among the elderly in the worldwide. One of the important pathogenic factors in AD is the aggregation of amyloid-β 1-42 (Aβ42) in AD patients' brain. Inhibition of Aβ peptide aggregation is considered as one of the effective approaches against AD.

Development of a soil heavy metal estimation method based on a spectral index: Combining fractional-order derivative pretreatment and the absorption mechanism.

Visible and near-infrared (Vis-NIR) reflectance is an effective way to estimate soil heavy metal content. In this study, in order to magnify the spectral information of the soil heavy metals and solve the collinearity and redundancy of hyperspectral datasets, we aimed to explore the potential of the fractional-order derivative (FOD) spectral pretreatment method and the band combination algorithm in soil heavy metal estimation. A total of 120 soil samples were collected in Xuzhou city, Jiangsu province, China, and their heavy metal contents and spectra were measured.

Robust Interlayer Exciton in WS/MoSe van der Waals Heterostructure under High Pressure.

The van der Waals (vdW) heterostructures have rich functions and intriguing physical properties, which has attracted wide attention. Effective control of excitons in vdW heterostructures is still urgent for fundamental research and realistic applications. Here, we successfully achieved quantitative tuning of the intralayer exciton of monolayers and observed the transition from intralayer excitons to interlayer excitons in WS/MoSe heterostructures, via hydrostatic pressure.

Effectiveness of Vitamin C Solution in Reducing Adverse Reactions Caused by Painless Lugol Chromoendoscopy: A Multicenter Randomized Controlled Trial.

Goal: The purpose of this study was to evaluate the effectiveness of vitamin C solution (VCS) in reducing adverse reactions caused by painless Lugol chromoendoscopy.

Background: Lugol chromoendoscopy is an effective method for screening superficial esophageal squamous cell carcinoma, although Lugol iodine solution (LIS) causes mucosal irritation.

Study: In 4 hospitals in China, patients were randomized and divided into a distilled water (DW) group, an sodium thiosulfate solution (STS) group and a VCS group.

Porous Au@Pt nanoparticles with superior peroxidase-like activity for colorimetric detection of spike protein of SARS-CoV-2.

The development of colorimetric assays for rapid and accurate diagnosis of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is of practical importance for point-of-care (POC) testing. Here we report the colorimetric detection of spike (S1) protein of SARS-CoV-2 based on excellent peroxidase-like activity of Au@Pt nanoparticles, with merits of rapidness, easy operation, and high sensitivity. The Au@Pt NPs were fabricated by a facile seed-mediated growth approach, in which spherical Au NPs were premade as seeds, followed by the Pt growth on Au seeds, producing uniform, monodispersed and porous Au@Pt core-shell NPs.

Detecting Toe-Off Events Utilizing a Vision-Based Method.

Detecting gait events from video data accurately would be a challenging problem. However, most detection methods for gait events are currently based on wearable sensors, which need high cooperation from users and power consumption restriction. This study presents a novel algorithm for achieving accurate detection of toe-off events using a single 2D vision camera without the cooperation of participants.

An efficient depth map preprocessing method based on structure-aided domain transform smoothing for 3D view generation.

Depth image-based rendering (DIBR), which is used to render virtual views with a color image and the corresponding depth map, is one of the key techniques in the 2D to 3D conversion process. Due to the absence of knowledge about the 3D structure of a scene and its corresponding texture, DIBR in the 2D to 3D conversion process, inevitably leads to holes in the resulting 3D image as a result of newly-exposed areas. In this paper, we proposed a structure-aided depth map preprocessing framework in the transformed domain, which is inspired by recently proposed domain transform for its low complexity and high efficiency.