An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer.

Background: Prostate cancer(PCa) ranks among the most frequently diagnosed malignancies in men. The progression and heterogeneity of tumors pose significant challenges to clinical prognosis and treatment strategies. Recently, extrachromosomal DNA(ecDNA) has emerged as a critical player in cancer biology, influencing tumor progression, metastasis, and resistance to therapy.

Four new earthworm species of the genera and (Oligochaeta, Megascolecidae) from Hunan and Anhui provinces, China.

This paper describes four new species earthworms from Hunan and Anhui provinces, China, Qiu & Jin, , Qiu & Jin, , Jin & Li, and Jin & Jiang, , and belong to the group. Both have four pairs of intersegmental spermathecal pores in 5/6-8/9; male pores in segment XVIII, separated by 1/3 of body circumference, each on top of a slightly raised porophore, surrounded by several tiny genital papillae. prostate glands are degenerated.

Utilizing Liquid-liquid phase separation-related lncRNAs to predict the prognosis and treatment response of PCa.

Background: Studies have indicated a close association between genes linked to liquid-liquid phase separation (LLPS) and the progression of prostate cancer (PCa). However, the interplay among long non-coding RNAs (lncRNAs) linked to LLPS in PCa remains elusive. Therefore, we constructed a prediction model based on LLPS-related LncRNA in PCa to explore its relationship with the prognosis and drug treatment of PCa.

Mitochondrial DNA evidence reflects high genetic divergence of (Oligochaeta: Megascolecidae) in southern China.

(Perrier, 1872), a natural resource used in traditional Chinese medicine (Guang-dilong) with high economic value, is widely distributed in forests and farmland habitats in the hilly areas of southern China. To investigate the extent of genetic differentiation and diversity in , a population genetic structure study was performed on 157 samples from 75 locations in southern China using the mitochondrial genes , , , , and . The results indicated that had a high level of genetic diversity, and variation within populations was the main source of the total variation.

Doxycycline decelerates aging in progeria mice.

Beyond the antimicrobial activity, doxycycline (DOX) exhibits longevity-promoting effect in nematodes, while its effect on mammals is unclear. Here, we applied a mouse model of Hutchinson-Gilford progeria syndrome (HGPS), Zmpste24 knockout (KO) mice, and analyzed the antiaging effect of DOX. We found that the DOX treatment prolongs lifespan and ameliorates progeroid features of Zmpste24 KO mice, including the decline of body and tissue weight, exercise capacity and cortical bone density, and the shortened colon length.

Three new species of the genus Amynthas (Oligochaeta: Megascolecidae) from Guangxi Zhuang Autonomous Region, China.

Three new earthworm species of the genus Amynthas Kinberg, 1867 were found in Guangxi Zhuang Autonomous Region, China: Amynthas huapingensis sp. nov., Amynthas retentus sp.

Dynamics of bacterial community in the foregut and hindgut of earthworms with the nutrition supplied by kitchen waste during vermicomposting.

Earthworm gut microbiota is vital in degrading bio-waste during vermicomposting. However, microbial dynamics in earthworm gut during this process are unclear. Thus, the aim is to firstly report the bacterial dynamics in both foregut and hindgut of earthworms over a 28 days' timeframe of vermicomposting by Eisenia foetida with the nutrition supplied by kitchen waste.

Discovery and Mechanism of Action of a Novel Antimicrobial Peptide from an Earthworm.

The robust innate immune system of the earthworm provides a potential source of natural antimicrobial peptides (AMPs). However, the cost and high rediscovery rate of direct separation and purification limits their discovery. Genome sequencing of numerous earthworm species facilitates the discovery of new antimicrobial peptides.

Physical and hydraulic properties of bioretention substrate using hexadecyl trimethyl ammonium bromide (HDTMA) modified zeolite.

This study using hexadecyl trimethyl ammonium bromide (HDTMA) modified zeolite as a component of bioretention substrate, to investigate the effect of HDTMA modification on the basic physical and hydraulic properties of substrate layer. Two different levels of HDTMA modified zeolite (ZHD10 and ZHD50) were mixed with a mixture consists of peat soil, river sand and compost (fixed volumetric proportion at 5:4:1) with varying volumetric percentage (25%, 50%, and 75%) to form substrate media. The modification only changes the physical properties of zeolite and media with zeolite slightly, while significant changes in surface hydrophobicity and hydraulic properties were observed.

Eco-risk management of tylosin fermentation residues using vermicomposting.

Tylosin fermentation residues (TFR) pose an ecotoxicological risk through antibiotic resistant bacteria (ARBs) and their corresponding genes (ARGs). This study evaluated the ecotoxicity of TFR to soil biological activity, and further explored the mechanisms of vermicomposting to reduce the toxicological risk. The results showed that tylosin (TYL) was moderately degradable with a half-life (t) of 37.

Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil.

The eco-risk of roxarsone (ROX) was evaluated using multiple responses of earthworm biomarkers under different ROX concentrations for 28 d. With the increasing total arsenic accumulation (TAs-E), biological responses in earthworm generally showed a two-stage changes of homeostasis dysregulation and dose-dependent alterations. At the early periods, ROX stress increased the reactive oxygen species (ROS) and lipid peroxidation (LPO) in a similar manner, and apparently disrupted mitochondrial calcium ([Ca]).

Toxicity assessment of earthworm exposed to arsenate using oxidative stress and burrowing behavior responses and an integrated biomarker index.

Arsenate (As-V) is a ubiquitous contaminant in soil as a result of excessive use of veterinary drugs and pesticides, causing enormous environmental risks. Multiple biomarkers have been used to assess the ecotoxicity of arsenic, however, the mechanisms of toxicity remain unclear. This paper describes the exposure of the earthworm (Eisenia fetida) to natural soil with different As-V concentrations for 28 days, then biomarkers from oxidative stress and burrowing behavior were quantified to evaluate As-V stress.

Three new widely distributed and polymorphic species of Amynthas earthworms (Oligochaeta, Clitellata, Megascolecidae) from South China.

Three new earthworm species are described from South China, namely Amynthas rusticanus sp. nov., Amynthas scaberulus sp.

Population Genetic Structure Reveals Two Lineages of (Oligochaeta: Megascolecidae) in China, with Notes on a New Subspecies of .

(Oligochaete: Megascolecidae) is a widely distributed endemic species in Southern China. To shed light on the population genetic diversity and to elucidate the population differentiation and dispersal of , a population genetic structure study was undertaken based on samples from 35 locations collected from 2010 to 2016. Two exclusive lineages within lineage A and lineage B-were revealed.

Comparative study of vermicomposting of garden waste and cow dung using Eisenia fetida.

Vermicomposting is the process of composting using worms and is applied in waste management to produce high-quality organic fertilizer. Garden waste (GW) is often mixed with other raw materials for vermicomposting. In the present study, the feasibility of vermicomposting using only GW was investigated in comparison with cow dung (CD).

Soil Behaviour of the Veterinary Drugs Lincomycin, Monensin, and Roxarsone and Their Toxicity on Environmental Organisms.

Lincomycin, monensin, and roxarsone are commonly used veterinary drugs. This study investigated their behaviours in different soils and their toxic effects on environmental organisms. Sorption and mobility analyses were performed to detect the migration capacity of drugs in soils.

Effects of Salinity on Earthworms and the Product During Vermicomposting of Kitchen Wastes.

Population growth and social changes have recently contributed to an exaggerated increase in kitchen wastes in China. Vermicomposting has recently been recognized as an effective and eco-friendly method of organic waste treatment through the combination of earthworms and microbes. However, the influence of salt in kitchen wastes on vermicomposting have been unknown.

Three new species and one subspecies of the -group from Guangxi Zhuang Autonomous Region, China (Oligochaeta, Megascolecidae).

Three new species and one subspecies of the genus are described from Guangxi Zhuang Autonomous Region, China: The new species are: Qiu & Dong, . and Qiu & Dong, , and Dong & Jiang, , the subspecies is All have four pairs of spermathecal pores in 5/6-8/9, which indicates that they should belong to the -group. Their morphological characteristics are compared to other similar species in the -group from China and other Asian countries, such as Sun & Jiang, 2013, (Chen, 1938), (Kinberg, 1867), Sun & Qiu, 2013, and (Goto & Hatai, 1899).

Three new species of earthworms (Oligochaeta: Megascolecidae) from Yunnan Province, China.

Earthworm specimens collected from Yunnan Province, China were found to represent three new species of Megascolecidae: Amynthas demptus sp. nov., Amynthas lacustris sp.

Four new Amynthas and Metaphire earthworm species from nine provinces in southern China.

Four new species belonging to genera Amyntha and Metaphire were discovered from an extensive area in southern China, covering the provinces Sichuan, Yunnan, Guizhou, Guangdong, Guangxi, Fujian, Hunan, Jiangxi and Anhui. The species are named Amynthas dispersus Sun Qiu, sp. nov.

New earthworm species of the genus Amynthas from Hainan Island, China (Megascolecidae, Clitellata).

Three new species of earthworms belonging to the genus Amynthas are described from Hainan Island, China. They are named Amynthas wenchangensis sp. nov.

Three new earthworm species of the tokioensis-group in the genus Amynthas (Oligochaeta: Megascolecidae) from Guangxi Province, China.

Three new species of the genus Amynthas are described from Guangxi Province, China. They are named A. dissimilis sp.

Two new species of earthworms belonging to the genus Amynthas (Oligochaeta: Megascolecidae) from Guangxi Province, China.

Two new species of earthworms belonging to the genus Amynthas are described from Guangxi Province, China: Amynthas crassitubus sp. nov. and Amynthas stabilis sp.

Hypoxic environment protects cowpea bruchid (Callosobruchus maculatus) from electron beam irradiation damage.

Background: Electron beam (eBeam) irradiation and hermetic storage are safe and effective technologies to protect stored products. Although hypoxic environment improves performance of some irradiated insects, whether hypoxia affects irradiation of storage insects and impacts pest control efficacy remains to be investigated.

Results: Using cowpea bruchid (Callosobruchus maculatus) larvae, we showed that, relative to eBeam irradiation under normoxia, the adult emergence rate increased substantially if they were exposed to hypoxia prior to and during eBeam treatment.