Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays.

Single-cell sequencing technologies have advanced our understanding of cellular heterogeneity and biological complexity. However, existing methods face limitations in throughput, capture uniformity, cell size flexibility, and technical extensibility. We present Stereo-cell, a spatial enhanced-resolution single-cell sequencing platform based on high-density DNA nanoball (DNB)-patterned arrays, which enables scalable and unbiased cell capture at a wide input range and supports high-fidelity transcriptome profiling.

Super-Heisenberg Scaling in a Triple-Point Criticality.

We investigate quantum-enhanced metrology in a triple point criticality and discover that quantum criticality does not always enhance measurement precision. We have developed suitable adiabatic evolution protocols to effectively restrain excitations, which could accelerate the adiabatic evolutions and lead to an exponential super-Heisenberg scaling. This scaling behavior is quite valuable in practical parameter estimating experiments with limited coherence time.

In Vitro Anti-Inflammatory Terpenoid Glycosides from the Seeds of .

To further explore the anti-inflammatory components of the seeds of L., a comprehensive phytochemical investigation was conducted using diverse chromatographic and spectrometric technologies, as well as chemical reactions. As a result, ten previously unreported terpenoid glycosides, namely dolilabterpenosides A, B, C-C, D, E, and F-F (-), along with four known analogues (-), initially identified from genus, were obtained.

Bioconversion of Alpha-Cembratriene-4,6-diol into High-Value Compound Farnesal Through Employment of a Novel H3-1 Strain.

Alpha-cembratriene-4,6-diol (α-CBT-diol) is a complex diterpenoid primarily found in (i.e., tobacco leaves), , and marine corals.

Constituents from L. Flowers and Their Anti-Inflammatory Effects via Inhibition of IL-1β Release.

The occurrence of inflammation is closely related to the activation of the NLRP3 inflammasome. IL-1β produced during the activation of the NLRP3 inflammasome has strong pro-inflammatory activity and can also promote the release of inflammatory factors by other immune cells, exacerbating inflammatory damage to tissues. Utilizing IL-1β as the detection index to find small-molecule inhibitors targeting NLRP3 from natural products will benefit the search for drugs for inflammation-related diseases.

Saponins from Dolichos lablab seeds with anti-inflammatory activity.

As one of a traditional Chinese medicine with dual applications in both medicinal treatment and dietary consumption, the mature seeds of D. lablab were reported to be rich in saponins and have a good effect on inflammatory related diseases. However, the substance basis for its anti-inflammatory activity remains unclear.

Aromatic compounds from the seeds of Dolichos lablab L. with anti-inflammatory activity.

Twenty-four aromatic compounds including five novel ones, dolilabphenosides A (1), B (2), B (3), C (4), and C (5) were obtained from the seeds of Dolichos lablab L. Their structures were established based on spectroscopic analyses and chemical reactions. Among the known compounds, 9, 10, 14, 17, 19, and 22-24 were gained from the family Leguminosae for the first time, and 6, 8, 11-13, 15, 16, 18, 20, as well as 21 were firstly identified from Dolichos genus.

Synthesis of -d Arene via Electrochemical Deuterodefluorination of Trifluoromethyl Arene.

The -d group is a new isotopic functional group for medicine design. In this work, we report an electrochemical deuteration approach for converting aromatic trifluoromethyl to -d groups with deuterium water in common DMF. Yields up to 94%, D ratio up to 97%, and CD incorporation up to 90% were achieved.

Understanding the Competitive Advantages of Car Sharing from the Travel-Cost Perspective.

The emergence and development of car sharing can not only satisfy people's diverse travel demands, but also can bring a new solution to facilitate urban low-carbon and green development. With the increasing acceptance of car sharing, the market competition between car sharing and traditional taxis is becoming increasingly fierce. Therefore, we explore the advantages of car sharing to travelers compared with taxis.