The Nα-acetyl-L-lysine/Loxl2/HO promotes intestinal tumor growth in Drosophila and cell proliferation in human colorectal cancer.

A cancer-associated microbiome is considered a carcinogen capable of affecting tumor initiation and/or progression. However, little is known about the molecular mechanisms of tumor-microbiome interactions. Here, we show that Staphylococcus sciuri promotes Drosophila intestinal tumor growth by inducing intestinal stem cell (ISC) division.

Pharmacokinetics of Enrofloxacin and Its Metabolite Ciprofloxacin in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Water Temperatures.

This study investigated the pharmacokinetics of enrofloxacin (ENR) and its primary metabolite, ciprofloxacin (CIP), in black rockfish (Sebastes schlegelii) following a single oral administration of ENR (10 mg/kg) under two water temperature conditions (13°C and 22°C). Serum samples were collected up to 168 h post-dosing and analyzed using a validated HPLC-MS/MS method. Contrary to conventional expectations, ENR absorption was delayed and elimination was slower at 22°C compared to 13°C, while the plasma concentrations of CIP were higher at the elevated temperature.

Pharmacological evaluation on benzimidazole anthelmintics for eradication of the gill fluke Microcotyle sebastis infesting a black rockfish, Sebastes schlegelii.

This study comprehensively evaluated the in vitro and in vivo anthelmintic efficacy and pharmacokinetics of four benzimidazole compounds: febantel (FB), fenbendazole (FBZ), albendazole (ABZ), and mebendazole (MBZ) against the gill fluke Microcotyle sebastis in cultured black rockfish (Sebastes schlegelii). In vitro tests with isolated adult parasites demonstrated that ABZ exhibited the highest efficacy, followed by FBZ, while MBZ showed minimal activity and FB remained largely inactive at lower concentrations. At the highest concentration tested (200 mg/L), FB showed only weak, nonspecific activity.

Effects of combined temperature and salinity on growth and fatty acid content of two Korean isolates of Akashiwo sanguinea (Dinophyceae).

Two Korean strains of Akashiwo sanguinea (LMBE-V203 and LMBE-V287) were established, and their morphologies and molecular phylogenies were examined. In addition, the effects of combined temperature and salinity on their growth and fatty acid contents were examined to evaluate the value as potential source for commercial application. Morphological observations indicated that there were no critical differences in the morphologies of both isolates, and molecular phylogeny based on LSU rRNA gene sequences revealed that the two isolates are nested within ribotype A of A.

Durable, High-Performance Silver-Based Transparent Electrodes with Anti-Reflection Coatings for Electroluminescent Devices.

A key challenge in flexible optoelectronics is developing transparent electrodes (TEs) with high optical and electrical performance that can survive deformation. Here, silver-based TEs with anti-reflection coatings (STEAR) are developed and demonstrate a sheet resistance of 8.9 Ω/sq, 85% transmittance (including the substrate), and stability over 16,000 bending cycles.

Text-Mining Analysis of Vision Statements Based on Korean Hospital Characteristics.

This study aimed to identify the status of hospital visions in Korea and understand the differences in vision based on hospital characteristics by conducting text mining. We collected 230 vision sentences from 85 Korean hospitals in 2024 through their websites. Major frequent words in visions were "Hospital," "Healthcare," "Lead," "Center," "Treatment," "Trust," "Patient," "Research," "Best," and "Customer" counted over 15 times.

Uncivil customers and work-family spillover: examining the buffering role of ethical leadership.

Background: This study investigates the impact of customer incivility on employee burnout and work-family conflict, examining the moderating role of ethical leadership in these relationships within the service industry. By integrating the Conservation of Resources theory and Role Theory, we seek to provide a more comprehensive understanding of how negative customer interactions affect employee well-being beyond the immediate work setting.

Methods: We conducted a two-wave, time-lagged survey among 586 full-time service sector employees in South Korea.

Durable Seawater Electrolysis through the Synergistic Effect of Oxidized MXene/Nickel Ferrite Composite Electrocatalyst.

Seawater electrolysis is a promising approach for sustainable and environmentally friendly hydrogen production, primarily because it has zero carbon emissions and mitigates freshwater resource scarcity. However, seawater electrolysis requires high selectivities for both the oxygen and hydrogen evolution reactions in an environment characterized by a high concentration of impurity ions, particularly Cl. In addition, the corrosion resistance of materials to byproducts is essential.

Exploration of a cultivation strategy to improve eicosapentaenoic acid (EPA) production and growth of a Korean strain of Nannochloropsis oceanica cultivated under different light sources.

To propose a strategy for the commercial cultivation of a Korean strain of Nannochloropsis oceanica, the growth, fatty acid content and bacterial community of N. oceanica cultures exposed to different light sources were investigated. Significant growth of N.

When Pressure Breeds Misconduct: Job Strain, Coworker Support, and Unethical Pro-Organizational Behavior.

Performance pressure is a pervasive organizational force with complex implications for employee behavior. Grounded in Conservation of Resources (COR) theory, this study examines how performance pressure influences unethical pro-organizational behavior (UPB) through the mediating role of job strain while also considering the moderating effect of perceived coworker support. Using survey data from 280 police officers, our findings demonstrate that performance pressure significantly increases UPB, with job strain serving as a key explanatory mechanism.

Comparative Pharmacological Assessment of Amoxicillin in Five Cultured Fish Species: Implications for Off-Label Use in Aquaculture.

: Amoxicillin (AMOX) is widely used in aquaculture for bacterial infections due to its efficacy and safety. Despite official approval for select species, off-label use is common. This study evaluated the antibacterial efficacy and residue depletion of AMOX in five aquaculture species: olive flounder (), rainbow trout (), Japanese eel (), black rockfish (), and Israeli carp ().

Strategic Surface Engineering of Lithium Metal Anodes: Simultaneous Native Layer Elimination and Protective Layer Formation Gas-Solid Reaction.

Lithium (Li) metal has received significant attention as an anode material for next-generation batteries due to its high theoretical capacity and low redox potential. However, the high reactivity of Li metal leads to the formation of a native layer on its surface, inducing nonuniform Li flux at the electrolyte/Li metal interface, which promotes the growth of Li metal dendrites. In this study, perfluorooctyltriethoxysilane (PFOTES) was vaporized to chemically react with the native layer and modify the Li metal surface.

Serum and Tissue Kinetics of Oxolinic Acid in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Temperatures.

The objective of this study was to investigate the pharmacokinetic (PK) properties of oxolinic acid (OA) in black rockfish (Sebastes schlegelii) following a single oral administration of 30 mg/kg at 13°C and 22°C. Serum and tissue (muscle, liver and kidney) samples were collected at pre-determined time points and analysed using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The results demonstrated that temperature significantly influenced the PK parameters of OA.

Photonic Sintering as an Electrode Structuring Process to Improve Electrocatalytic Activity and Durability in Anion Exchange Membrane Water Electrolysis.

Hydrogen production via water electrolysis is essential for achieving carbon-free energy. However, enhancing the performance of these systems, particularly at the electrode level, remains challenging. Photonic sintering (PS) is proposed as a highly effective post-treatment method for electrodes, highlighting the importance of electrode design and optimization.

Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila.

While it is now accepted that the microbiome has strong impacts on animal growth promotion, the exact mechanism has remained elusive. Here we show that microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host growth in an olfaction-independent manner in Drosophila. We found that inhaled VSFs are readily sensed by olfactory receptor 42b non-neuronally expressed in subsets of tracheal airway cells, enteroendocrine cells, and enterocytes.

PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1.

Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy characterized by the blockage of myeloid cell differentiation and uncontrolled proliferation of immature myeloid cells. Here, we show that paraspeckle component 1 (PSPC1) is aberrantly overexpressed and associated with poor survival in AML patients. Using human AML cells and mouse models, we demonstrate that PSPC1 is not required for normal hematopoiesis, but it is critical and essential for AML cells to maintain their leukemic characteristics.

Mitigating Diffusion-Induced Intragranular Cracking in Single-Crystal LiNiMnO via Extended Solid-Solution Behavior.

Single-crystal cathodes have been investigated for their inherent resistance to intergranular cracking due to the absence of grain boundaries. However, these materials exhibit significant intragranular cracking, and the underlying mechanisms remain unclear. In this study, we examined the impact of extended solid-solution reactions on mitigating crack formation in magnesium-doped single-crystal LiNiMnO (Mg-SC-LNMO) cathodes.

Effects of Marigold Extract and Carophyll Red on Growth, Body Color Development, Antioxidant Properties, and Innate Immunity in the Ornamental Fish Golden Severum ().

The body color state is an important determinant of the value of golden severum ()-a popular ornamental fish. The use of dietary supplements to improve the color development and health of this species is unexplored. Herein, the effects of marigold extract (MG) and carophyll red (CR) are examined on the growth, body color development, antioxidant properties, and innate immunity in golden severum.

ATM in immunobiology: From lymphocyte development to cancer immunotherapy.

Ataxia Telangiectasia Mutated (ATM) is a protein kinase traditionally known for its role in DNA damage response and cell cycle regulation. However, emerging research has revealed its multifaceted and crucial functions in the immune system. This comprehensive review explores the diverse roles of ATM in immune regulation, from lymphocyte development to its involvement in cancer immunotherapy.

Denatonium inhibits RANKL-induced osteoclast differentiation and rescues the osteoporotic phenotype by blocking p65 signaling pathway.

Background: Bone remodeling is a critical process that maintains skeletal integrity, orchestrated by the balanced activities of osteoclasts, which resorb bone, and osteoblasts, which form bone. Osteoclastogenesis, the formation of osteoclasts, is primarily driven by NFATc1, a process activated through c-Fos and NF-κB signaling pathways in response to receptor activator of nuclear factor κB ligand (RANKL). Dysregulation of RANKL signaling is a key contributor to pathological bone loss, as seen in conditions such as osteoporosis.

Detoxification of ars genotypes by arsenite-oxidizing bacteria through arsenic biotransformation.

The detoxification process of transforming arsenite (As(III)) to arsenate (As(V)) through bacterial oxidation presents a potent approach for bioremediation of arsenic-polluted soils in abandoned mines. In this study, twelve indigenous arsenic-oxidizing bacteria (AOB) were isolated from arsenic-contaminated soils. Among these, Paenibacillus xylanexedens EBC-SK As2 (MF928871) and Ochrobactrum anthropi EBC-SK As11 (MF928880) were identified as the most effective arsenic-oxidizing isolates.

Modulation of Amyloid and Tau Aggregation to Alleviate Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease.

Aggregation of misfolded amyloid-β (Aβ) and hyperphosphorylated tau proteins to plaques and tangles, respectively, is the major drug target of Alzheimer's disease (AD), as the former is an onset biomarker and the latter is associated with neurodegeneration. Thus, we report a small molecule drug candidate, DN5355, with a dual-targeting function toward aggregates of both Aβ and tau. DN5355 was selected through a series of four screenings assessing 52 chemicals for their functions to inhibit and reverse the aggregation of Aβ and tau by utilizing thioflavin T.

Assessment of Lambda-Cyhalothrin and Spinetoram Toxicity and Their Effects on the Activities of Antioxidant Enzymes and Acetylcholinesterase in Honey Bee () Larvae.

Honeybees play a crucial role as agricultural pollinators and are frequently exposed to various pollutants, including pesticides. In this study, we aimed to evaluate the toxicity of lambda-cyhalothrin (LCY) and spinetoram (SPI) in honey bee larvae reared in vitro through single (acute) and repeated (chronic) exposure. The acute LD values for LCY and SPI were 0.