Comparative Pharmacological Assessment of Amoxicillin in Five Cultured Fish Species: Implications for Off-Label Use in Aquaculture.

: Amoxicillin (AMOX) is widely used in aquaculture for bacterial infections due to its efficacy and safety. Despite official approval for select species, off-label use is common. This study evaluated the antibacterial efficacy and residue depletion of AMOX in five aquaculture species: olive flounder (), rainbow trout (), Japanese eel (), black rockfish (), and Israeli carp ().

Serum and Tissue Kinetics of Oxolinic Acid in Black Rockfish (Sebastes schlegelii) Following a Single Oral Administration at Two Temperatures.

The objective of this study was to investigate the pharmacokinetic (PK) properties of oxolinic acid (OA) in black rockfish (Sebastes schlegelii) following a single oral administration of 30 mg/kg at 13°C and 22°C. Serum and tissue (muscle, liver and kidney) samples were collected at pre-determined time points and analysed using high-performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS). The results demonstrated that temperature significantly influenced the PK parameters of OA.